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Abstract:

The reconsolidation hypothesis has challenged the traditional view of fixed memories after consolidation. Reconsolidation studies have disclosed that the mechanisms mediating memory retrieval and the mechanisms that underlie the behavioral expression of memory can be dissociated, offering a new prospect for understanding the nature of experimental amnesia. The muscarinic antagonist scopolamine has been used for decades to induce experimental amnesias The goal of the present study is to determine whether the amnesic effects of scopolamine are due to storage (or retrieval) deficits or, alternatively, to a decrease in the long-term memory expression of a consolidated long-term memory. In the crab Chasmagnathus memory model, we found that scopolamine-induced amnesia can be reverted by facilitation after reminder presentation. This recovery of memory expression was reconsolidation specific since a reminder that does not triggers reconsolidation process did not allow the recovery. A higher dose (5 μg/g) of scopolamine induced an amnesic effect that could not be reverted through reconsolidation, and thus it can be explained as an interference with memory storage and/or retrieval mechanisms. These results, showing that an effective amnesic dose of scopolamine (100. ng/g) negatively modulates long-term memory expression but not memory storage in the crab Chasmagnathus, are consistent with the concept that dissociable processes underlie the mechanisms mediating memory reactivation and the behavioral expression of memory. © 2012 Elsevier Inc.

Registro:

Documento: Artículo
Título:Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage
Autor:Caffaro, P.A.; Suárez, L.D.; Blake, M.G.; Delorenzi, A.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, FCEyN, Universidad de Buenos Aires, IFIBYNE-CONICET, Argentina
Laboratorio de Neurofarmacología de los Procesos de Memoria, Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina
Palabras clave:Amnesia; Chasmagnathus; Memory expression; Reconsolidation; Retrieval; Scopolamine; scopolamine; amnesia; animal behavior; animal experiment; animal model; article; associative memory; Chasmagnathus granulatus; conditioning; controlled study; crab; escape behavior; facilitation; long term memory; male; memory consolidation; memory reactivation; memory reconsolidation; mental dissociation; nonhuman; stimulus; visual danger stimulus; Amnesia; Animals; Behavior, Animal; Brachyura; Male; Memory; Memory, Long-Term; Muscarinic Antagonists; Scopolamine Hydrobromide
Año:2012
Volumen:98
Número:3
Página de inicio:235
Página de fin:245
DOI: http://dx.doi.org/10.1016/j.nlm.2012.08.003
Título revista:Neurobiology of Learning and Memory
Título revista abreviado:Neurobiol. Learn. Mem.
ISSN:10747427
CODEN:NLMEF
CAS:scopolamine, 138-12-5, 51-34-3, 55-16-3; Muscarinic Antagonists; Scopolamine Hydrobromide, 51-34-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v98_n3_p235_Caffaro

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Citas:

---------- APA ----------
Caffaro, P.A., Suárez, L.D., Blake, M.G. & Delorenzi, A. (2012) . Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage. Neurobiology of Learning and Memory, 98(3), 235-245.
http://dx.doi.org/10.1016/j.nlm.2012.08.003
---------- CHICAGO ----------
Caffaro, P.A., Suárez, L.D., Blake, M.G., Delorenzi, A. "Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage" . Neurobiology of Learning and Memory 98, no. 3 (2012) : 235-245.
http://dx.doi.org/10.1016/j.nlm.2012.08.003
---------- MLA ----------
Caffaro, P.A., Suárez, L.D., Blake, M.G., Delorenzi, A. "Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage" . Neurobiology of Learning and Memory, vol. 98, no. 3, 2012, pp. 235-245.
http://dx.doi.org/10.1016/j.nlm.2012.08.003
---------- VANCOUVER ----------
Caffaro, P.A., Suárez, L.D., Blake, M.G., Delorenzi, A. Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage. Neurobiol. Learn. Mem. 2012;98(3):235-245.
http://dx.doi.org/10.1016/j.nlm.2012.08.003