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Abstract:

Recently encoded information can be lost in the presence of new information, a process called '. retrograde interference'. Retrograde interference has been extensively described for more than a century; however, little is known about its underlying mechanisms. Different approaches agree on the need of the synthesis of plasticity related proteins (PRPs) to consolidate a long-term memory (LTM). Our hypothesis is that when PRPs are limited, interference of a task over LTM formation of another may be due to the utilization of protein resources common to both tasks. Here, by combining the tasks of inhibitory avoidance (IA) and open field (OF) exploration in rats, we show that memory traces compete for their stabilization if PRPs are limited. As a result, LTM is formed for only one of the tasks with a consequent decrease in the memory for the other. Furthermore, infusing Arc antisense oligonucleotide into the dorsal hippocampus, we found that Arc is necessary for LTM formation of these two types of learning tasks and is one of the PRPs that can be shared between them when animals are trained in both OF and IA. In sum, these findings suggest that under conditions of reduced protein availability, a learning task interferes with LTM formation of another by using the available PRPs. © 2012 Elsevier Inc.

Registro:

Documento: Artículo
Título:Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference
Autor:Martínez, M.C.; Alen, N.; Ballarini, F.; Moncada, D.; Viola, H.
Filiación:Laboratorio de Memoria, Instituto de Biología Celular y Neurociencia Prof. E. De Robertis, Facultad de Medicina, Universidad de Buenos Aires, CONICET, Paraguay 2155 3 piso, C1121ABG, Buenos Aires, Argentina
Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160, Ciudad Universitaria, C1428EG Buenos Aires, Argentina
Palabras clave:Arc (activity-regulated cytoskeletal-associated protein); Hippocampus; Memory interference; Rat; activity regulated cytoskeleton associated protein; antisense oligonucleotide; amnesia; animal experiment; animal model; article; avoidance behavior; controlled study; exploratory behavior; hippocampus; learning; long term memory; male; memory; memory consolidation; memory interference; mental performance; mental task; nerve cell plasticity; nonhuman; open field behavior; protein synthesis regulation; rat; Animals; Avoidance Learning; Cytoskeletal Proteins; Exploratory Behavior; Hippocampus; Male; Memory, Long-Term; Nerve Tissue Proteins; Oligonucleotides, Antisense; Rats; Rats, Wistar
Año:2012
Volumen:98
Número:2
Página de inicio:165
Página de fin:173
DOI: http://dx.doi.org/10.1016/j.nlm.2012.05.007
Título revista:Neurobiology of Learning and Memory
Título revista abreviado:Neurobiol. Learn. Mem.
ISSN:10747427
CODEN:NLMEF
CAS:Cytoskeletal Proteins; Nerve Tissue Proteins; Oligonucleotides, Antisense; activity regulated cytoskeletal-associated protein
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v98_n2_p165_Martinez

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Citas:

---------- APA ----------
Martínez, M.C., Alen, N., Ballarini, F., Moncada, D. & Viola, H. (2012) . Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference. Neurobiology of Learning and Memory, 98(2), 165-173.
http://dx.doi.org/10.1016/j.nlm.2012.05.007
---------- CHICAGO ----------
Martínez, M.C., Alen, N., Ballarini, F., Moncada, D., Viola, H. "Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference" . Neurobiology of Learning and Memory 98, no. 2 (2012) : 165-173.
http://dx.doi.org/10.1016/j.nlm.2012.05.007
---------- MLA ----------
Martínez, M.C., Alen, N., Ballarini, F., Moncada, D., Viola, H. "Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference" . Neurobiology of Learning and Memory, vol. 98, no. 2, 2012, pp. 165-173.
http://dx.doi.org/10.1016/j.nlm.2012.05.007
---------- VANCOUVER ----------
Martínez, M.C., Alen, N., Ballarini, F., Moncada, D., Viola, H. Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference. Neurobiol. Learn. Mem. 2012;98(2):165-173.
http://dx.doi.org/10.1016/j.nlm.2012.05.007