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With the aim of analyzing if object recognition long-term memory (OR-LTM) formation is susceptible to retroactive interference (RI), we submitted rats to sequential sample sessions using the same arena but changing the identity of a pair of objects placed in it. Separate groups of animals were tested in the arena in order to evaluate the LTM for these objects. Our results suggest that OR-LTM formation was retroactively interfered within a critical time window by the exploration of a new, but not familiar, object. This RI acted on the consolidation of the object explored in the first sample session because its OR-STM measured 3 h after training was not affected, whereas the OR-LTM measured at 24 h was impaired. This sample session also impaired the expression of OR memory when it took place before the test. Moreover, local inactivation of the dorsal Hippocampus (Hp) or the medial Prefrontal Cortex (mPFC) previous to the exploration of the second pair of objects impaired their consolidation restoring the LTM for the objects explored in the first session. This data suggests that both brain regions are involved in the processing of OR-memory and also that if those regions are engaged in another process before finishing the first consolidation process its LTM will be impaired by RI. © 2016 Elsevier Inc.


Documento: Artículo
Título:Memory consolidation and expression of object recognition are susceptible to retroactive interference
Autor:Villar, M.E.; Martinez, M.C.; Lopes da Cunha, P.; Ballarini, F.; Viola, H.
Filiación:Instituto de Biología Celular y Neurociencias “Prof. Eduardo de Robertis”, Facultad de Medicina – Universidad de Buenos Aires – CONICET, Paraguay 2155 – 3rd floor, Ciudad Autónoma de Buenos Aires, Buenos Aires C1121ABG, Argentina
Laboratorio de Fisiología de Circuitos Neuronales, Departamento de Fisiología, Facultad de Medicina, Instituto de Fisiología y Biofísica “Bernardo Houssay”, Universidad de Buenos Aires – CONICET, Paraguay 2155 – 7th floor, Ciudad Autónoma de Buenos Aires, Buenos Aires C1121ABG, Argentina
Departamento de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160, Ciudad UniversitariaBuenos Aires, Argentina
Palabras clave:Dorsal hippocampus; Long-term memory; Medial prefrontal cortex; Object recognition task; Rat; Retroactive interference; animal experiment; brain region; dorsal hippocampus; long term memory; medial prefrontal cortex; memory consolidation; nonhuman; recognition; animal; drug effects; hippocampus; long term memory; male; memory; memory consolidation; physiology; prefrontal cortex; rat; recognition; Wistar rat; 4 aminobutyric acid A receptor stimulating agent; muscimol; Animals; GABA-A Receptor Agonists; Hippocampus; Male; Memory; Memory Consolidation; Memory, Long-Term; Muscimol; Prefrontal Cortex; Rats; Rats, Wistar; Recognition (Psychology)
Página de inicio:198
Página de fin:205
Título revista:Neurobiology of Learning and Memory
Título revista abreviado:Neurobiol. Learn. Mem.
CAS:muscimol, 2763-96-4; GABA-A Receptor Agonists; Muscimol


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---------- APA ----------
Villar, M.E., Martinez, M.C., Lopes da Cunha, P., Ballarini, F. & Viola, H. (2017) . Memory consolidation and expression of object recognition are susceptible to retroactive interference. Neurobiology of Learning and Memory, 138, 198-205.
---------- CHICAGO ----------
Villar, M.E., Martinez, M.C., Lopes da Cunha, P., Ballarini, F., Viola, H. "Memory consolidation and expression of object recognition are susceptible to retroactive interference" . Neurobiology of Learning and Memory 138 (2017) : 198-205.
---------- MLA ----------
Villar, M.E., Martinez, M.C., Lopes da Cunha, P., Ballarini, F., Viola, H. "Memory consolidation and expression of object recognition are susceptible to retroactive interference" . Neurobiology of Learning and Memory, vol. 138, 2017, pp. 198-205.
---------- VANCOUVER ----------
Villar, M.E., Martinez, M.C., Lopes da Cunha, P., Ballarini, F., Viola, H. Memory consolidation and expression of object recognition are susceptible to retroactive interference. Neurobiol. Learn. Mem. 2017;138:198-205.