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Abstract:

The neural correlates of memory have been usually examined considering that memory retrieval and memory expression are interchangeable concepts. However, our studies in the crab Neohelice (Chasmagnathus) granulata and in other memory models have shown that memory expression is not necessary for memory to be re-activated and become labile. In order to examine putative neural correlates of memory in the crab Neohelice, we contrast changes induced by training in both animal's behavior and neuronal responses in the medulla terminalis using in vivo Ca2+ imaging. Disruption of long-term memory by the amnesic agents MK-801 or scopolamine (5 μg/g) blocks the learning-induced changes in the Ca2+ responses in the medulla terminalis. Conversely, treatments that lead to an unexpressed but persistent memory (weak training protocol or scopolamine 0.1 μg/g) do not block these learning-induced neural changes. The present results reveal a set of changes in the neural activity induced by training that correlates with memory persistence but not with the probability of this memory to be expressed in the long-term. In addition, the study constitutes the first in vivo evidence in favor of a role of the medulla terminalis in learning and memory in crustaceans, and provides a physiological evidence indicating that memory persistence and the probability of memory to be expressed might involve separate components of memory traces. © 2016 Elsevier Inc.

Registro:

Documento: Artículo
Título:Neural correlates of expression-independent memories in the crab Neohelice
Autor:Maza, F.J.; Locatelli, F.F.; Delorenzi, A.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, FCEyN, IFIByNE-CONICET, Pabellón II, Universidad de Buenos Aires, Ciudad Universitaria (C1428EHA), Argentina
Palabras clave:Calcium imaging; Memory; Memory expression; Reconsolidation; Retrieval; calcium ion; amino acid receptor blocking agent; dizocilpine maleate; muscarinic receptor blocking agent; scopolamine bromide; animal behavior; animal cell; animal experiment; animal tissue; Article; behavior assessment; brain; brain function; brain region; cell activity; cell function; controlled study; crab; functional assessment; in vivo study; long term memory; male; medulla terminalis; memory; memory expression; memory persistence; molecular dynamics; molecular imaging; Neohelice; nonhuman; recall; short term memory; signal detection; stimulus response; animal; Brachyura; drug effects; ganglion; memory; memory consolidation; physiology; Animals; Behavior, Animal; Brachyura; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ganglia, Invertebrate; Male; Memory; Memory Consolidation; Memory, Long-Term; Mental Recall; Muscarinic Antagonists; Scopolamine Hydrobromide
Año:2016
Volumen:131
Página de inicio:61
Página de fin:75
DOI: http://dx.doi.org/10.1016/j.nlm.2016.03.011
Título revista:Neurobiology of Learning and Memory
Título revista abreviado:Neurobiol. Learn. Mem.
ISSN:10747427
CODEN:NLMEF
CAS:calcium ion, 14127-61-8; dizocilpine maleate, 77086-22-7; scopolamine bromide, 114-49-8; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Muscarinic Antagonists; Scopolamine Hydrobromide
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v131_n_p61_Maza

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Citas:

---------- APA ----------
Maza, F.J., Locatelli, F.F. & Delorenzi, A. (2016) . Neural correlates of expression-independent memories in the crab Neohelice. Neurobiology of Learning and Memory, 131, 61-75.
http://dx.doi.org/10.1016/j.nlm.2016.03.011
---------- CHICAGO ----------
Maza, F.J., Locatelli, F.F., Delorenzi, A. "Neural correlates of expression-independent memories in the crab Neohelice" . Neurobiology of Learning and Memory 131 (2016) : 61-75.
http://dx.doi.org/10.1016/j.nlm.2016.03.011
---------- MLA ----------
Maza, F.J., Locatelli, F.F., Delorenzi, A. "Neural correlates of expression-independent memories in the crab Neohelice" . Neurobiology of Learning and Memory, vol. 131, 2016, pp. 61-75.
http://dx.doi.org/10.1016/j.nlm.2016.03.011
---------- VANCOUVER ----------
Maza, F.J., Locatelli, F.F., Delorenzi, A. Neural correlates of expression-independent memories in the crab Neohelice. Neurobiol. Learn. Mem. 2016;131:61-75.
http://dx.doi.org/10.1016/j.nlm.2016.03.011