Abstract:
Memories can be altered by negative or arousing experiences due to the activation of the stress-responsive sympatho-adrenal-medullary axis (SYM). Here, we used a neutral declarative memory that was acquired during multi-trial training to determine the effect of a threatening event on memory without emotional valence. To this end, participants received a new threatening social protocol before learning pairs of meaningless syllables and were tested either 15. min, 2. days or 8. days after acquisition. We first demonstrated that this threatening social situation activates not only the SYM axis (Experiment 1) and the hypothalamus-pituitary-adrenal axis (HPA; Experiment 2), but also, it improves the acquisition or early consolidation of the syllable pairs (Experiment 3). This improvement is not a transient effect; it can be observed after the memory is consolidated. Furthermore, this modulation increases the persistence of memory (Experiment 4). Thus, it is possible to affect memories with specific events that contain unrelated content and a different valence. © 2015 Elsevier Inc.
Registro:
Documento: |
Artículo
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Título: | Positive modulation of a neutral declarative memory by a threatening social event |
Autor: | Fernández, R.S.; Bavassi, L.; Campos, J.; Allegri, R.F.; Molina, V.A.; Forcato, C.; Pedreira, M.E. |
Filiación: | Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Facultad de Ciencias Exactas y Naturales, Biología Molecular y Celular, IFIBYNE-CONICET, Universidad de Buenos Aires, Argentina Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Buenos Aires, Argentina Departamento de Farmacología, IFEC/CONICET-UNC, Facultad de Ciencias Químicas, Córdoba, Argentina
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Palabras clave: | Autonomic nervous system; Memory improvement; Memory persistence; Neutral declarative memory; Pre-learning stress; Psychosocial stress; adult; Article; controlled study; declarative memory; emotionality; experimental study; female; human; human experiment; hypothalamus hypophysis adrenal system; life event; life threat; male; memory consolidation; mental performance; neuroanatomy; neuromodulation; normal human; social behavior; sympatho-adrenal-medullary axis; adrenergic system; affect; blood pressure; heart rate; hypophysis adrenal system; hypothalamus hypophysis system; memory; mental stress; metabolism; physiology; speech; young adult; hydrocortisone; Adult; Affect; Blood Pressure; Female; Heart Rate; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Memory; Pituitary-Adrenal System; Speech; Stress, Psychological; Sympathetic Nervous System; Young Adult |
Año: | 2015
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Volumen: | 126
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Página de inicio: | 56
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Página de fin: | 66
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DOI: |
http://dx.doi.org/10.1016/j.nlm.2015.10.011 |
Título revista: | Neurobiology of Learning and Memory
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Título revista abreviado: | Neurobiol. Learn. Mem.
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ISSN: | 10747427
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CODEN: | NLMEF
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CAS: | hydrocortisone, 50-23-7; Hydrocortisone
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v126_n_p56_Fernandez |
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Citas:
---------- APA ----------
Fernández, R.S., Bavassi, L., Campos, J., Allegri, R.F., Molina, V.A., Forcato, C. & Pedreira, M.E.
(2015)
. Positive modulation of a neutral declarative memory by a threatening social event. Neurobiology of Learning and Memory, 126, 56-66.
http://dx.doi.org/10.1016/j.nlm.2015.10.011---------- CHICAGO ----------
Fernández, R.S., Bavassi, L., Campos, J., Allegri, R.F., Molina, V.A., Forcato, C., et al.
"Positive modulation of a neutral declarative memory by a threatening social event"
. Neurobiology of Learning and Memory 126
(2015) : 56-66.
http://dx.doi.org/10.1016/j.nlm.2015.10.011---------- MLA ----------
Fernández, R.S., Bavassi, L., Campos, J., Allegri, R.F., Molina, V.A., Forcato, C., et al.
"Positive modulation of a neutral declarative memory by a threatening social event"
. Neurobiology of Learning and Memory, vol. 126, 2015, pp. 56-66.
http://dx.doi.org/10.1016/j.nlm.2015.10.011---------- VANCOUVER ----------
Fernández, R.S., Bavassi, L., Campos, J., Allegri, R.F., Molina, V.A., Forcato, C., et al. Positive modulation of a neutral declarative memory by a threatening social event. Neurobiol. Learn. Mem. 2015;126:56-66.
http://dx.doi.org/10.1016/j.nlm.2015.10.011