Artículo

Barreiro, K.A.; Suárez, L.D.; Lynch, V.M.; Molina, V.A.; Delorenzi, A. "Memory expression is independent of memory labilization/reconsolidation" (2013) Neurobiology of Learning and Memory. 106:283-291
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Abstract:

There is growing evidence that certain reactivation conditions restrict the onset of both the destabilization phase and the restabilization process or reconsolidation. However, it is not yet clear how changes in memory expression during the retrieval experience can influence the emergence of the labilization/reconsolidation process. To address this issue, we used the context-signal memory model of Chasmagnathus. In this paradigm a short reminder that does not include reinforcement allows us to evaluate memory labilization and reconsolidation, whereas a short but reinforced reminder restricts the onset of such a process. The current study investigated the effects of the glutamate antagonists, APV (0.6 or 1.5. μg/g) and CNQX (1. μg/g), prior to the reminder session on both behavioral expression and the reconsolidation process. Under conditions where the reminder does not initiate the labilization/reconsolidation process, APV prevented memory expression without affecting long-term memory retention. In contrast, APV induced amnesic effects in the long-term when administered before a reminder session that triggers reconsolidation. Under the present parametric conditions, the administration of CNQX prior to the reminder that allows memory to enter reconsolidation impairs this process without disrupting memory expression. Overall, the present findings suggest that memory reactivation - but not memory expression- is necessary for labilization and reconsolidation. Retrieval and memory expression therefore appear not to be interchangeable concepts. © 2013 Elsevier Inc.

Registro:

Documento: Artículo
Título:Memory expression is independent of memory labilization/reconsolidation
Autor:Barreiro, K.A.; Suárez, L.D.; Lynch, V.M.; Molina, V.A.; Delorenzi, A.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y, Biología Molecular, IFIByNE-CONICET, FCEyN, Universidad de, Pabellón II, Buenos Aires, Ciudad Universitaria (C1428EHA), Argentina
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, IFEC-CONICET (X5000HUA), Argentina
Palabras clave:Amnesia; APV; CNQX; Memory expression; Reconsolidation; Retrieval; 2 amino 5 phosphonovaleric acid; 6 cyano 7 nitro 2,3 quinoxalinedione; amnesia; animal experiment; animal model; article; Chasmagnathus granulatus; controlled study; crab; information retrieval; long term memory; male; memory; memory consolidation; memory expression; memory labilization; nonhuman; reinforcement; Amnesia; APV; CNQX; Memory expression; Reconsolidation; Retrieval; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Association Learning; Brachyura; Escape Reaction; Excitatory Amino Acid Antagonists; Freezing Reaction, Cataleptic; Memory; Mental Recall; Retention (Psychology); Valine
Año:2013
Volumen:106
Página de inicio:283
Página de fin:291
DOI: http://dx.doi.org/10.1016/j.nlm.2013.10.006
Título revista:Neurobiology of Learning and Memory
Título revista abreviado:Neurobiol. Learn. Mem.
ISSN:10747427
CODEN:NLMEF
CAS:2 amino 5 phosphonovaleric acid, 76726-92-6; 6 cyano 7 nitro 2,3 quinoxalinedione, 115066-14-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v106_n_p283_Barreiro

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Citas:

---------- APA ----------
Barreiro, K.A., Suárez, L.D., Lynch, V.M., Molina, V.A. & Delorenzi, A. (2013) . Memory expression is independent of memory labilization/reconsolidation. Neurobiology of Learning and Memory, 106, 283-291.
http://dx.doi.org/10.1016/j.nlm.2013.10.006
---------- CHICAGO ----------
Barreiro, K.A., Suárez, L.D., Lynch, V.M., Molina, V.A., Delorenzi, A. "Memory expression is independent of memory labilization/reconsolidation" . Neurobiology of Learning and Memory 106 (2013) : 283-291.
http://dx.doi.org/10.1016/j.nlm.2013.10.006
---------- MLA ----------
Barreiro, K.A., Suárez, L.D., Lynch, V.M., Molina, V.A., Delorenzi, A. "Memory expression is independent of memory labilization/reconsolidation" . Neurobiology of Learning and Memory, vol. 106, 2013, pp. 283-291.
http://dx.doi.org/10.1016/j.nlm.2013.10.006
---------- VANCOUVER ----------
Barreiro, K.A., Suárez, L.D., Lynch, V.M., Molina, V.A., Delorenzi, A. Memory expression is independent of memory labilization/reconsolidation. Neurobiol. Learn. Mem. 2013;106:283-291.
http://dx.doi.org/10.1016/j.nlm.2013.10.006