Forcato, C.; Burgos, V.L.; Argibay, P.F.; Molina, V.A.; Pedreira, M.E.; Maldonado, H. "Reconsolidation of declarative memory in humans" (2007) Learning and Memory. 14(4):295-303
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The reconsolidation hypothesis states that a consolidated memory could again become unstable and susceptible to facilitation or impairment for a discrete period of time after a reminder presentation. The phenomenon has been demonstrated in very diverse species and types of memory, including the human procedural memory of a motor skill task but not the human declarative one. Here we provide evidence for both consolidation and reconsolidation in a paired-associate learning (i.e., learning an association between a cue syllable and the respective response syllable). Subjects were given two training sessions with a 24-h interval on distinct verbal material, and afterward, they received at testing two successive retrievals corresponding to the first and second learning, respectively. Two main results are noted. First, the first acquired memory was impaired when a reminder was presented 5 min before the second training (reconsolidation), and also when the second training was given 5 min instead of 24 h after the first one (consolidation). Second, the first retrieval proved to influence negatively on the later one (the retrieval-induced forgetting [RIF] effect), and we used the absence of this RIF effect as a very indicator of the target memory impairment. We consider the demonstration of reconsolidation in human declarative memory as backing the universality of this phenomenon and having potential clinical relevance. On the other hand, we discuss the possibility of using the human declarative memory as a model to address several key topics of the reconsolidation hypothesis. ©2007 by Cold Spring Harbor Laboratory Press.


Documento: Artículo
Título:Reconsolidation of declarative memory in humans
Autor:Forcato, C.; Burgos, V.L.; Argibay, P.F.; Molina, V.A.; Pedreira, M.E.; Maldonado, H.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología Y Biología Molecular Y Celular, Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina
Unidad de Ciencias Cognitivas, Instituto de Ciencias Básicas Y Medicina Experimental, Hospital Italiano de Buenos Aires, C1181ACH Buenos Aires, Argentina
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000 Cordoba, Argentina
Palabras clave:adult; article; association; controlled study; declarative memory; female; human; human experiment; male; memory consolidation; memory disorder; normal human; priority journal; state dependent learning; Adult; Cues; Female; Humans; Male; Memory; Mental Recall; Paired-Associate Learning; Time Factors
Página de inicio:295
Página de fin:303
Título revista:Learning and Memory
Título revista abreviado:Learn. Mem.


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---------- APA ----------
Forcato, C., Burgos, V.L., Argibay, P.F., Molina, V.A., Pedreira, M.E. & Maldonado, H. (2007) . Reconsolidation of declarative memory in humans. Learning and Memory, 14(4), 295-303.
---------- CHICAGO ----------
Forcato, C., Burgos, V.L., Argibay, P.F., Molina, V.A., Pedreira, M.E., Maldonado, H. "Reconsolidation of declarative memory in humans" . Learning and Memory 14, no. 4 (2007) : 295-303.
---------- MLA ----------
Forcato, C., Burgos, V.L., Argibay, P.F., Molina, V.A., Pedreira, M.E., Maldonado, H. "Reconsolidation of declarative memory in humans" . Learning and Memory, vol. 14, no. 4, 2007, pp. 295-303.
---------- VANCOUVER ----------
Forcato, C., Burgos, V.L., Argibay, P.F., Molina, V.A., Pedreira, M.E., Maldonado, H. Reconsolidation of declarative memory in humans. Learn. Mem. 2007;14(4):295-303.