Abstract:
In previous experiments on contextual memory, we proposed that the unreinforced re-exposure to the learning context (conditioned stimulus, CS) acts as a switch guiding the memory course toward reconsolidation or extinction, depending on reminder duration. This proposal implies that the system computes the total exposure time to the context, from CS onset to CS offset, and therefore, that the reminder presentation must be terminated for the switching mechanism to become operative. Here we investigated to what extent this requirement is necessary, and we explored the relation between diverse phases in the reconsolidation and extinction processes. We used the contextual memory model of the crab Chasmagnathus which involves an association between the learning context (CS) and a visual danger stimulus (unconditioned stimulus, US). Administration of cycloheximide was used to test the lability state of memory at different time points. The results show that two factors, no-reinforcement during the reminder (i.e., CS re-exposure) and CS offset are the necessary conditions for both processes to occur. Regardless of the reminder duration, memory retrieved by unreinforced CS re-exposure emerges intact and consolidated when tested before CS offset, suggesting that neither reconsolidation nor extinction is concomitant with CS re-exposure. Either process could only be triggered once the definitive mismatch between CS and US is confirmed by CS termination without the expected reinforcement.
Registro:
Documento: |
Artículo
|
Título: | Mismatch between what is expected and what actually occurs triggers memory reconsolidation or extinction |
Autor: | Pedreira, M.E.; Pérez-Cuesta, L.M.; Maldonado, H. |
Filiación: | Depto. de Fisiol., Biol. Molec./Cel., IFIBYNE-CONICET, Universidad de Buenos Aires, Buenos Aires, C1428EHA, Argentina
|
Palabras clave: | animal experiment; article; Chasmagnathus; conditioned reflex; conditioning; controlled study; crab; learning; male; memory consolidation; neurophysiology; neuropsychology; nonhuman; priority journal; reinforcement; time; visual memory; visual stimulation; Animals; Association Learning; Brachyura; Cues; Cycloheximide; Environment; Escape Reaction; Extinction, Psychological; Male; Memory; Protein Biosynthesis; Protein Synthesis Inhibitors; Reinforcement (Psychology) |
Año: | 2004
|
Volumen: | 11
|
Número: | 5
|
Página de inicio: | 579
|
Página de fin: | 585
|
DOI: |
http://dx.doi.org/10.1101/lm.76904 |
Título revista: | Learning and Memory
|
Título revista abreviado: | Learn. Mem.
|
ISSN: | 10720502
|
CODEN: | LEMEF
|
CAS: | Cycloheximide, 66-81-9; Protein Synthesis Inhibitors
|
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10720502_v11_n5_p579_Pedreira |
Referencias:
- Anokhin, K.V., Tiunova, A.A., Rose, S.P., Reminder effects-reconsolidation or retrieval deficit? Pharmacological dissection with protein synthesis inhibitors following reminder for a passive avoidance task in young chicks (2002) Eur. J. Neurosci., 15, pp. 1759-1765
- Herman, D.E., Dudai, Y., Memory extinction, learning anew, and learning the new: Dissociations in the molecular machinery of learning in cortex (2001) Science, 291, pp. 2417-2419
- Bouton, M., Context, ambiguity, and unlearning: Source of relapse after behavioural extinction (2002) Biol. Psychiatry, 52, pp. 976-986
- Brooks, D.C., Bouton, M.E., A retrieval cue for extinction attenuates response recovery (renewal) caused by return to the conditioning context (1994) J. Exp. Psychol. Anim. Behav. Process, 20, pp. 366-379
- Debiec, J., LeDoux, J.E., Nader, K., Cellular and systems reconsolidation in the hippocampus (2002) Neuron, 36, pp. 527-538
- Dudai, Y., (2002) Memory from A to Z. Keywords, Concepts, and Beyond, , Oxford UP, Oxford, UK
- Eisenberg, M., Kobilo, T., Berman, D.E., Dudai, Y., Stability of retrieved memory: Inverse correlation with trace dominance (2003) Science, 301, pp. 1102-1104
- Freudenthal, R., Romano, A., Participation of Rel/NFκB transcription factors in long-term memory in the crab Chasmagnathus (2000) Brain Res., 885, pp. 274-281
- Hoeger, R., Florey, E., Catecholamine degradation in the hemolymph of the Chinese crab, Eriocheir sinesis (1989) Comp. Biochem. Physiol., 92 C, pp. 323-327
- Howell, D.C., (1987) Statistical Methods for Psychology, , Duxbury, Boston
- Locatelli, F., Maldonado, H., Romano, A., Two critical periods for cAMP dependent protein kinase activity during long-term memory consolidation in the crab Chasmagnathus (2002) Neurobiol. Learn. Mem., 77, pp. 234-249
- Lozada, M., Romano, A., Maldonado, H., Long-term habituation to a danger stimulus in the crab Chasmagnathus granulatus (1990) Physiol. Behav., 47, pp. 35-41
- Maldonado, H., Crustacean as model to investigate memory illustrated by extensive behavioral and physiological studies in Chasmagnathus (2002) The Crustacean Nervous System, pp. 314-327. , (ed. K. Wiese). Springer-Verlag Berlin, Heidelberg, Germany
- Merlo, E., Freudenthal, R., Romano, A., The IκB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus (2002) Neurosci., 112, pp. 161-172
- Nadel, L., Land, C., Memory traces revisited (2000) Nat. Rev. Neurosci., 1, pp. 209-212
- Nader, K., Schafe, G.E., LeDoux, J.E., Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval (2000) Nature, 406, pp. 722-726
- The labile nature of consolidation theory (2000) Nat. Neurosci. Rev., 1, pp. 210-219
- Pedreira, M.E., Maldonado, H., Protein synthesis subserves reconsolidation or extinction depending on reminder duration (2003) Neuron, 38, pp. 863-869
- Pedreira, M.E., Dimant, B., Tomsic, D., Quesada-Allué, L.A., Maldonado, H., Cycloheximide inhibits context memory and long-term habituation in the crab Chasmagnathus (1995) Pharmacol. Biochem. Behav., 52, pp. 385-395
- Pedreira, M.E., Dimant, B., Maldonado, H., Inhibitors of protein and RNA synthesis block context memory and long-term habituation in the crab Chasmagnathus (1996) Pharmacol. Biochem. Behav., 54, pp. 611-617
- Pedreira, M.E., Pérez-Cuesta, L.M., Maldonado, H., Reactivation and reconsolidation of long-term memory in the crab Chasmagnathus: Protein synthesis requirement and mediation by NMDA-type glutamatergic receptors (2002) J. Neurosci., 22, pp. 8305-8311
- Pereyra, P., Saraco, M., Maldonado, H., Decreased response or alternative defensive strategy in escape: Two novel types of long-term memory in the crab Chasmagnathus (1999) J. Comp. Physiol., 184, pp. 301-310
- Pereyra, P., González Portino, E., Maldonado, H., Conditioned defensive freezing in the crab is context-specific but not triggered by the context (2000) Neurobiol. Learn. Mem., 74, pp. 119-134
- Rescorla, R.A., Behavioral studies of pavlovian conditioning (1988) Annu. Rev. Neurosci., 1, pp. 320-352
- Romano, A., Locatelli, F., Delorenzi, A., Pedreira, M.E., Maldonado, H., Effects of activation and inhibition of cAMP-dependent protein kinase on long-term habituation in the crab Chasmagnathus (1996) Brain Res., 735, pp. 131-140
- Rosenthal, R., Rosnow, R.L., (1985) Contrast Analysis Focused Comparisons in the Analysis of Variance, , Cambridge UP, Cambridge, UK
- Sangha, S., Scheibenstock, A., Lukowiac, K., Reconsolidation for a long-term memory in Lymnea requires new protein and RNA synthesis and the soma of right pedal dorsal 1 (2003) J. Neurosci., 23, pp. 8034-8040
- Sara, S.J., Retrieval and reconsolidation: Toward a neurobiology of remembering (2000) Learn. Mem., 7, pp. 73-84
- Strengthening the shaky trace through retrieval (2000) Nat. Neurosci. Rev., 1, pp. 212-213
- Tomsic, D., Pedreira, M.E., Hermitte, G., Romano, A., Maldonado, H., Context-US association as a determinant of long-term habituation in the crab Chasmagnathus (1998) Anim. Learn. Behav., 26, pp. 196-209
- Troncoso, J., Maldonado, H., Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists (2002) Pharmacol. Biochem. Behav., 72, pp. 251-265
- Vianna, M.R.M., Szapiro, G., McGaugh, J.L., Medina, J.H., Izquierdo, I., Retrieval of memory for fear-motivated training initiate extinction requiring protein synthesis in the rat hippocampus (2001) Proc. Natl. Acad. Sci., 98, pp. 12251-12254
Citas:
---------- APA ----------
Pedreira, M.E., Pérez-Cuesta, L.M. & Maldonado, H.
(2004)
. Mismatch between what is expected and what actually occurs triggers memory reconsolidation or extinction. Learning and Memory, 11(5), 579-585.
http://dx.doi.org/10.1101/lm.76904---------- CHICAGO ----------
Pedreira, M.E., Pérez-Cuesta, L.M., Maldonado, H.
"Mismatch between what is expected and what actually occurs triggers memory reconsolidation or extinction"
. Learning and Memory 11, no. 5
(2004) : 579-585.
http://dx.doi.org/10.1101/lm.76904---------- MLA ----------
Pedreira, M.E., Pérez-Cuesta, L.M., Maldonado, H.
"Mismatch between what is expected and what actually occurs triggers memory reconsolidation or extinction"
. Learning and Memory, vol. 11, no. 5, 2004, pp. 579-585.
http://dx.doi.org/10.1101/lm.76904---------- VANCOUVER ----------
Pedreira, M.E., Pérez-Cuesta, L.M., Maldonado, H. Mismatch between what is expected and what actually occurs triggers memory reconsolidation or extinction. Learn. Mem. 2004;11(5):579-585.
http://dx.doi.org/10.1101/lm.76904