Artículo

Daraio, M.E.; François, N.; Bernik, D.L. "Correlation between gel structural properties and drug release pattern in scleroglucan matrices" (2003) Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents. 10(2):79-85
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The drug delivery behavior of scleroglucan hydrogels was correlated with the structural features found by means of steady-state fluorescence studies. Theophylline at 0.4 % in weight was used as the model drug and its release was measured using a Franz cell device. The results were fitted with a semi-empirical power law equation, finding significant differences between the 0.5% and higher than 0.8% scleroglucan concentrations (w/w). Four molecular fluorescent probes were used to test microenvironmental properties of the gel cavities, which will play a key role on the release of the pharmaceutical drugs. The results found by the fluorescence analysis are in good agreement with the ones obtained by release kinetics.

Registro:

Documento: Artículo
Título:Correlation between gel structural properties and drug release pattern in scleroglucan matrices
Autor:Daraio, M.E.; François, N.; Bernik, D.L.
Filiación:Lab. Quimica de Sist. Heterogeneos, Facultad de Ingeniería, Universidad de Buenos Aires, Buenos Aires, Argentina
Lab. de Sistemas Líquidos, Facultad de Ingeniería, Universidad de Buenos Aires, Buenos Aires, Argentina
Inst. Quimica Fisica de los Mat., Ambiente y Energía, Universidad de Buenos Aires, Buenos Aires, Argentina
INQUIMAE, Cuidad Universitaria, Pabellon 2, Buenos Aires 1428, Argentina
Palabras clave:Drug Release; Fluorescent Molecular Probes; Hydrophilic Matrices; Scleroglucan; scleroglucan; theophylline; analytic method; article; chemical model; correlation analysis; drug delivery system; drug release; empiricism; fluorescence analysis; hydrogel; kinetics; mathematical analysis; microenvironment; molecular probe; priority journal; steady state
Año:2003
Volumen:10
Número:2
Página de inicio:79
Página de fin:85
DOI: http://dx.doi.org/10.1080/713840361
Título revista:Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents
Título revista abreviado:Drug Deliv. J. Deliv. Targeting Ther. Agents
ISSN:10717544
CODEN:DDELE
CAS:scleroglucan, 39464-87-4; theophylline, 58-55-9, 5967-84-0, 8055-07-0, 8061-56-1, 99007-19-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10717544_v10_n2_p79_Daraio

Referencias:

  • Alhaique, F., Carafa, M., Riccieri, F.M., Santucci, E., Touitou, E., Studies on the release behaviour of a polysaccharide matrix (1993) Pharmazie, 48, pp. 432-436
  • Alvarez-Lorenzo, C., Gómez Amoza, J.L., Martínez Pacheco, R., Souto, C., Concheiro, A., Microviscosity of hydroxypropylcellulose gels as bases for prediction of drug diffusion rates (1999) Int. J. Pharm., 180, pp. 91-103
  • Annaka, M., Noda, H., Motokawa, R., Nakahira, T., Fluorescence study on multiple phase behavior of dimethylamide-methacrylic acid copolymer gel (2001) Polymer, 42, pp. 9887-9894
  • Aramendía, P.F., Negri, R.M., San Roman, E.A., Temperature dependence of fluorescence and photoisomerization in symmetric carbocyanines. Influence of medium viscosity and molecular structure (1994) J. Phys. Chem., 98, pp. 3165-3173
  • Barreiro-Iglesias, R., Alvarez-Lorenzo, C., Concheiro, A., Incorporation of small quantities of surfactants as a way to improve the rheological and diffusional behavior of carbopol gels (2001) J. Con. Rel., 77, pp. 59-75
  • Baptista, M.S., Indig, G.L., Effect of BSA binding on photophysical and photochemicals properties of triarylmethane dyes (1998) J. Phys. Chem. B, 102, pp. 4678-4688
  • Berezhokovskii, A.M., Bezrukov, S.M., Bicout, D.J., Weiss, G.H., The influence of polymer on the diffusion of a spherical tracer (1999) J. Chem. Phys., 111, pp. 5641-5644
  • Bernik, D., Negri, R.M., De Schryver, F.C., Global analysis of unmatched polarized fluorescence decay curves of systems exhibiting a residual anisotropy at long times (1996) J. Phys. Chem., 100, pp. 9751-9761
  • Bernik, D., Negri, R.M., Local polarity at the polar head level of lipid vesicles using Dansyl fluorescent probes (1998) J. Coll. Interface Sci., 203, pp. 97-105
  • Clarke, R.J., Kane, D.J., Optical detection of membrane dipole potential: Avoidance of fluidity and dye-induced effects (1997) Biochim. Biophys. Acta, 1323, pp. 223-229
  • Coviello, T., Dentini, M., Rambone, G., Desideri, P., Carafa, M., Murtas, E., Riccieri, F.M., Alhaique, F., A novel co-crosslinked polysaccharide: Studies for a controlled delivery matrix (1998) J. Contr. Rel., 55, pp. 57-66. , and references therein
  • Coviello, T., Grassi, M., Rambone, G., Santucci, E., Carafa, M., Murtas, E., Riccieri, F.M., Alhaique, F., Novel hydrogel system from scleroglucan: Synthesis and characterization (1999) J. Contr. Rel., 60, pp. 367-378. , and references therein
  • Dale, R.E., Chen, L.A., Brand, L., Rotational relaxation of the "microviscosity" probe diphenylhexatriene in paraffin oil and egg lecithin vesicles (1977) J. Biol. Chem., 252, pp. 7500-7510
  • Demchenko, A.P., Scherbatska, N.V., Nanosecond dynamics of charged fluorescent probes at the polar interface of a membrane phospholipid bilayer (1985) Biophys. Chem., 22, pp. 131-143
  • De Nooy, A.E.J., Rori, V., Masci, G., Dentini, M., Crescenzi, V., Synthesis and preliminary characterisation of charged derivatives and hydrogels from scleroglucan (2000) Carbohy. Res., 324, pp. 116-126. , and references therein
  • Domecq, A., Florenzano, F., Disalvo, E.A., Politi, M.J., Bernik, D.L., Stability test of liposome preparations using routine steady-state fluorescent measurements (2001) Drug Del., 8, pp. 155-160
  • Grassi, M., Lapasin, R., Pricl, S., A study of the rheological behavior of scleroglucan weak gel systems (1996) Carbohydrate Polymers, 29, pp. 169-181
  • Harrison, G., Franks, G.V., Tirtaatmadja, V., Boger, D.V., Suspensions and polymers - Common links in rheology (1999) Korea-Australia Rheology Journal, 11, pp. 197-218
  • Kaholek, M., Hrdlovic, P., Bartos, J., Singlet probes based on coumarin derivatives substituted in position 3; spectral properties in solution and in polymer matrices (2000) J. Polymer, 41, pp. 991-1001
  • Kim, H., Fassihi, R., Application of a binary polymer system in drug release rate modulation. 1. Characterization of release mechanism (1997) J. Pharm. Sci., 86, pp. 316-322
  • Lakowicz, J.R., (1999) Principles of Fluorescence Spectroscopy, , Kluwer Academic/Plenum Publishers, New York, USA
  • Lakowicz, J.R., Keating-Nakamoto, S., Red-edge excitation of fluorescence and dynamic properties of proteins and membranes (1984) Biochemistry, 23, pp. 3013-3021
  • Marchi, M.C., Aldabe-Bilmes, S., Negri, R.M., Microviscosity in the cavities of titania gels studied by steady-state fluorescence anisotropy (1997) Langmuir, 13, pp. 3665-3672
  • Norisuye, T., Yanaki, T., Fujita, H., Dynamics during thermoreversible gelation of the polysaccharide schizophyllan (1980) J. Polym. Sci. Polym. Phys. Ed., 18, pp. 547-558
  • Peppas, N.A., Sahlin, J.L., A simple equation for the description of solute release. III. Coupling of diffusion and relaxation (1989) Int. J. Pharm., 57, pp. 169-172
  • Ritger, P.L., Peppas, N.A., A simple equation for description of solute release. II. Fickian and anomalous release from swellable devices (1987) J. Contr Rel., 5, pp. 37-42
  • Siepmann, J., Peppas, N.A., Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC) (2001) Adv. Drug Del. Rev., 48, pp. 139-157

Citas:

---------- APA ----------
Daraio, M.E., François, N. & Bernik, D.L. (2003) . Correlation between gel structural properties and drug release pattern in scleroglucan matrices. Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents, 10(2), 79-85.
http://dx.doi.org/10.1080/713840361
---------- CHICAGO ----------
Daraio, M.E., François, N., Bernik, D.L. "Correlation between gel structural properties and drug release pattern in scleroglucan matrices" . Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents 10, no. 2 (2003) : 79-85.
http://dx.doi.org/10.1080/713840361
---------- MLA ----------
Daraio, M.E., François, N., Bernik, D.L. "Correlation between gel structural properties and drug release pattern in scleroglucan matrices" . Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents, vol. 10, no. 2, 2003, pp. 79-85.
http://dx.doi.org/10.1080/713840361
---------- VANCOUVER ----------
Daraio, M.E., François, N., Bernik, D.L. Correlation between gel structural properties and drug release pattern in scleroglucan matrices. Drug Deliv. J. Deliv. Targeting Ther. Agents. 2003;10(2):79-85.
http://dx.doi.org/10.1080/713840361