Artículo

Salamone, P.C.; Esteves, S.; Sinay, V.J.; García-Cordero, I.; Abrevaya, S.; Couto, B.; Adolfi, F.; Martorell, M.; Petroni, A.; Yoris, A.; Torquati, K.; Alifano, F.; Legaz, A.; Cassará, F.P.; Bruno, D.; Kemp, A.H.; Herrera, E.; García, A.M. (...) Sedeño, L. "Altered neural signatures of interoception in multiple sclerosis" (2018) Human Brain Mapping. 39(12):4743-4754
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Abstract:

Multiple sclerosis (MS) patients present several alterations related to sensing of bodily signals. However, no specific neurocognitive impairment has yet been proposed as a core deficit underlying such symptoms. We aimed to determine whether MS patients present changes in interoception—that is, the monitoring of autonomic bodily information—a process that might be related to various bodily dysfunctions. We performed two studies in 34 relapsing–remitting, early-stage MS patients and 46 controls matched for gender, age, and education. In Study 1, we evaluated the heartbeat-evoked potential (HEP), a cortical signature of interoception, via a 128-channel EEG system during a heartbeat detection task including an exteroceptive and an interoceptive condition. Then, we obtained whole-brain MRI recordings. In Study 2, participants underwent fMRI recordings during two resting-state conditions: mind wandering and interoception. In Study 1, controls exhibited greater HEP modulation during the interoceptive condition than the exteroceptive one, but no systematic differences between conditions emerged in MS patients. Patients presented atrophy in the left insula, the posterior part of the right insula, and the right anterior cingulate cortex, with abnormal associations between neurophysiological and neuroanatomical patterns. In Study 2, controls showed higher functional connectivity and degree for the interoceptive state compared with mind wandering; however, this pattern was absent in patients, who nonetheless presented greater connectivity and degree than controls during mind wandering. MS patients were characterized by atypical multimodal brain signatures of interoception. This finding opens a new agenda to examine the role of inner-signal monitoring in the body symptomatology of MS. © 2018 Wiley Periodicals, Inc.

Registro:

Documento: Artículo
Título:Altered neural signatures of interoception in multiple sclerosis
Autor:Salamone, P.C.; Esteves, S.; Sinay, V.J.; García-Cordero, I.; Abrevaya, S.; Couto, B.; Adolfi, F.; Martorell, M.; Petroni, A.; Yoris, A.; Torquati, K.; Alifano, F.; Legaz, A.; Cassará, F.P.; Bruno, D.; Kemp, A.H.; Herrera, E.; García, A.M.; Ibáñez, A.; Sedeño, L.
Filiación:Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina
National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina
Institute of Biomedical Engineering, Buenos Aires University, Argentina
Applied Artificial Intelligence Laboratory, Computer Science Department, Buenos Aires University. ICC-CONICET, Argentina
School of Psychology and Discipline of Psychiatry, University of Sydney, Sydney, NSW, Australia
Department of Psychological Studies, ICESI University, Cali, Colombia
Faculty of Education, National University of Cuyo (UNCuyo), Centro Universitario, Mendoza, Argentina
Neuroscience Research Australia, Sydney, Australia and School of Medical Sciences, The University of New South Wales, Sydney, NSW, Australia
Australian Research Council (ACR) Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, NSW, Australia
Universidad Autónoma del Caribe, Barranquilla, Colombia
Department of Psychology, Universidad Adolfo Ibáñez, Santiago, Chile
Palabras clave:body perception; functional connectivity; heartbeat detection task; heartbeat evoked potential; interoceptive processing; multiple sclerosis; adult; anterior cingulate; Article; brain atrophy; clinical article; controlled study; electroencephalogram; evoked response; female; functional connectivity; heart beat; human; insula; interoception; male; multiple sclerosis; neuroanatomy; neurophysiology; priority journal
Año:2018
Volumen:39
Número:12
Página de inicio:4743
Página de fin:4754
DOI: http://dx.doi.org/10.1002/hbm.24319
Título revista:Human Brain Mapping
Título revista abreviado:Hum. Brain Mapp.
ISSN:10659471
CODEN:HBMAE
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10659471_v39_n12_p4743_Salamone

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Citas:

---------- APA ----------
Salamone, P.C., Esteves, S., Sinay, V.J., García-Cordero, I., Abrevaya, S., Couto, B., Adolfi, F.,..., Sedeño, L. (2018) . Altered neural signatures of interoception in multiple sclerosis. Human Brain Mapping, 39(12), 4743-4754.
http://dx.doi.org/10.1002/hbm.24319
---------- CHICAGO ----------
Salamone, P.C., Esteves, S., Sinay, V.J., García-Cordero, I., Abrevaya, S., Couto, B., et al. "Altered neural signatures of interoception in multiple sclerosis" . Human Brain Mapping 39, no. 12 (2018) : 4743-4754.
http://dx.doi.org/10.1002/hbm.24319
---------- MLA ----------
Salamone, P.C., Esteves, S., Sinay, V.J., García-Cordero, I., Abrevaya, S., Couto, B., et al. "Altered neural signatures of interoception in multiple sclerosis" . Human Brain Mapping, vol. 39, no. 12, 2018, pp. 4743-4754.
http://dx.doi.org/10.1002/hbm.24319
---------- VANCOUVER ----------
Salamone, P.C., Esteves, S., Sinay, V.J., García-Cordero, I., Abrevaya, S., Couto, B., et al. Altered neural signatures of interoception in multiple sclerosis. Hum. Brain Mapp. 2018;39(12):4743-4754.
http://dx.doi.org/10.1002/hbm.24319