Sedeño, L.; Piguet, O.; Abrevaya, S.; Desmaras, H.; García-Cordero, I.; Baez, S.; Alethia de la Fuente, L.; Reyes, P.; Tu, S.; Moguilner, S.; Lori, N.; Landin-Romero, R.; Matallana, D.; Slachevsky, A.; Torralva, T.; Chialvo, D.; Kumfor, F.; García, A.M. (...) Ibanez, A."Tackling variability: A multicenter study to provide a gold-standard network approach for frontotemporal dementia" (2017) Human Brain Mapping. 38(8):3804-3822
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Biomarkers represent a critical research area in neurodegeneration disease as they can contribute to studying potential disease-modifying agents, fostering timely therapeutic interventions, and alleviating associated financial costs. Functional connectivity (FC) analysis represents a promising approach to identify early biomarkers in specific diseases. Yet, virtually no study has tested whether potential FC biomarkers prove to be reliable and reproducible across different centers. As such, their implementation remains uncertain due to multiple sources of variability across studies: the numerous international centers capable conducting FC research vary in their scanning equipment and their samples’ socio-cultural background, and, more troublingly still, no gold-standard method exists to analyze FC. In this unprecedented study, we aim to address both issues by performing the first multicenter FC research in the behavioral-variant frontotemporal dementia (bvFTD), and by assessing multiple FC approaches to propose a gold-standard method for analysis. We enrolled 52 bvFTD patients and 60 controls from three international clinics (with different fMRI recording parameters), and three additional neurological patient groups. To evaluate FC, we focused on seed analysis, inter-regional connectivity, and several graph-theory approaches. Only graph-theory analysis, based on weighted-matrices, yielded consistent differences between bvFTD and controls across centers. Also, graph metrics robustly discriminated bvFTD from the other neurological conditions. The consistency of our findings across heterogeneous contexts highlights graph-theory as a potential gold-standard approach for brain network analysis in bvFTD. Hum Brain Mapp 38:3804–3822, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.


Documento: Artículo
Título:Tackling variability: A multicenter study to provide a gold-standard network approach for frontotemporal dementia
Autor:Sedeño, L.; Piguet, O.; Abrevaya, S.; Desmaras, H.; García-Cordero, I.; Baez, S.; Alethia de la Fuente, L.; Reyes, P.; Tu, S.; Moguilner, S.; Lori, N.; Landin-Romero, R.; Matallana, D.; Slachevsky, A.; Torralva, T.; Chialvo, D.; Kumfor, F.; García, A.M.; Manes, F.; Hodges, J.R.; Ibanez, A.
Filiación:Institute of Cognitive and Translational Neuroscience (INCyT), INECO Foundation, Favaloro University, Buenos Aires, Argentina
National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina
Neuroscience Research Australia, Sydney, Australia
School of Medical Sciences, The University of New South Wales, Sydney, Australia
School of Psychology, Central Clinical School & Brain and Mind Centre, University of Sydney; Neuroscience Research Australia; ARC Centre of Excellence in Cognition and its Disorders, New South Wales, Australia
Universidad de los Andes, Bogota, Colombia
Intellectus Memory and Cognition Center, Mental Health and Psychiatry Department, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Colombia
FMRIB, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, United Kingdom
Brain and Mind Centre, Sydney Medical School, University of Sydney, Sydney, Australia
Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, Australia
Fundación Escuela de Medicina Nuclear (FUESMEN) and Comisión Nacional de Energía Atómica (CNEA), Buenos Aires, Argentina
Instituto Balseiro and Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo (UNCuyo), Mendoza, Argentina
INECO Neurociencias Oroño, Grupo Oroño, Rosario, Argentina
Centro Algoritmi, University of Minho, Guimarães, Portugal
Laboratory of Neuroimaging and Neuroscience (LANEN), INECO Foundation Rosario, Rosario, Argentina
Physiopathology Department, ICBM Neuroscience Department, Faculty of Medicine, University of Chile, Santiago, Chile
Cognitive Neurology and Dementia, Neurology Department, Hospital del Salvador, Providencia, Santiago, Chile
Gerosciences Center for Brain Health and Metabolism, Santiago, Chile
Centre for Advanced Research in Education, Santiago, Chile
Center for Complex Systems & Brain Sciences - Escuela de Ciencia y Tecnologia. UNSAM/Campus Miguelete, Argentina
Faculty of Education, National University of Cuyo (UNCuyo), Mendoza, Argentina
Universidad Autonoma del Caribe, Barranquilla, Colombia
Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibañez, Santiago, Chile
Palabras clave:biomarkers; frontotemporal dementia; functional connectivity; graph-theory and neurodegenerative diseases; adult; Article; brain mapping; controlled study; diagnostic test accuracy study; disease control; female; frontal variant frontotemporal dementia; functional connectivity; functional magnetic resonance imaging; gold standard; human; major clinical study; male; middle aged; multicenter study; neuroimaging; nuclear magnetic resonance scanner; posterior cingulate; priority journal; resting state network; sensitivity and specificity; single photon emission computed tomography; voxel based morphometry
Página de inicio:3804
Página de fin:3822
Título revista:Human Brain Mapping
Título revista abreviado:Hum. Brain Mapp.


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---------- APA ----------
Sedeño, L., Piguet, O., Abrevaya, S., Desmaras, H., García-Cordero, I., Baez, S., Alethia de la Fuente, L.,..., Ibanez, A. (2017) . Tackling variability: A multicenter study to provide a gold-standard network approach for frontotemporal dementia. Human Brain Mapping, 38(8), 3804-3822.
---------- CHICAGO ----------
Sedeño, L., Piguet, O., Abrevaya, S., Desmaras, H., García-Cordero, I., Baez, S., et al. "Tackling variability: A multicenter study to provide a gold-standard network approach for frontotemporal dementia" . Human Brain Mapping 38, no. 8 (2017) : 3804-3822.
---------- MLA ----------
Sedeño, L., Piguet, O., Abrevaya, S., Desmaras, H., García-Cordero, I., Baez, S., et al. "Tackling variability: A multicenter study to provide a gold-standard network approach for frontotemporal dementia" . Human Brain Mapping, vol. 38, no. 8, 2017, pp. 3804-3822.
---------- VANCOUVER ----------
Sedeño, L., Piguet, O., Abrevaya, S., Desmaras, H., García-Cordero, I., Baez, S., et al. Tackling variability: A multicenter study to provide a gold-standard network approach for frontotemporal dementia. Hum. Brain Mapp. 2017;38(8):3804-3822.