Artículo
Gomez, M.L.; Resnicoff, M.; Medrano, E.E.; Tellez-Inon, M.T. "The increase in cytosolic levels of protein kinase C precedes the growth factor requirements during the transition stem cells to differentiated progeny in the MCF-7 breast tumor cells." (1993) Cell Biology International. 17(5):495-502
Estamos trabajando para incorporar este artículo al repositorio
Consulte la política de Acceso Abierto del editor
Abstract:
The expression of regulatory genes within the context of a differentiation program can have profound long-term consequences in tissues with permanent renewing populations. The breast tumor cell line MCF-7 retains in culture some of the characteristics of a unidirectional differentiation pathway. We show that the cytosolic activity of the regulatory enzyme protein kinase C (PKC) precedes and continues the sequence of maturation in pre-differentiated subpopulations derived from a stem cell fraction. However, the activity declines in the most differentiated, post-mitotic fraction. These results indicate that PKC may be considered among the regulatory genes in MCF-7 cells that specify maturation of the stem cell progeny. © 1993 Academic Press. All rights reserved.
Registro:
| Documento: | Artículo |
| Título: | The increase in cytosolic levels of protein kinase C precedes the growth factor requirements during the transition stem cells to differentiated progeny in the MCF-7 breast tumor cells. |
| Autor: | Gomez, M.L.; Resnicoff, M.; Medrano, E.E.; Tellez-Inon, M.T. |
| Filiación: | Instituto de Ingeniera Genetica y Biologia Molecular (INGEBI, CONICET) Instituto de Investigaciones Bioquimicas Luis F. Leloir, Facultad de Ciencias Exactas y Naturales (UBA), Buenos Aires. Argentina and Present Address: Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio; Thomas Jefferson University, Bluemle Life Sciences Building Philadelphia, PA 19107 and Department of Dermatology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati Ohio, 45267-0592 USA. |
| Palabras clave: | growth factor; protein kinase c; article; breast tumor; cell differentiation; cell maturation; cell subpopulation; cytosol; enzyme activity; gene expression; human; human cell; priority journal; regulator gene; stem cell; tumor cell line; Breast Neoplasms; Cell Differentiation; Cytosol; Female; Genes, Regulator; Growth Substances; Human; Protein Kinase C; Tumor Cells, Cultured; Tumor Stem Cells |
| Año: | 1993 |
| Volumen: | 17 |
| Número: | 5 |
| Página de inicio: | 495 |
| Página de fin: | 502 |
| DOI: | http://dx.doi.org/10.1006/cbir.1993.1090 |
| Título revista: | Cell Biology International |
| Título revista abreviado: | Cell Biol. Int. |
| ISSN: | 10656995 |
| CODEN: | CBIIE |
| CAS: | protein kinase C, 141436-78-4; Growth Substances; Protein Kinase C, EC 2.7.1.37 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10656995_v17_n5_p495_Gomez |
Citas:
---------- APA ----------
Gomez, M.L., Resnicoff, M., Medrano, E.E. & Tellez-Inon, M.T. (1993) . The increase in cytosolic levels of protein kinase C precedes the growth factor requirements during the transition stem cells to differentiated progeny in the MCF-7 breast tumor cells. Cell Biology International, 17(5), 495-502.http://dx.doi.org/10.1006/cbir.1993.1090
---------- CHICAGO ----------
Gomez, M.L., Resnicoff, M., Medrano, E.E., Tellez-Inon, M.T. "The increase in cytosolic levels of protein kinase C precedes the growth factor requirements during the transition stem cells to differentiated progeny in the MCF-7 breast tumor cells." Cell Biology International 17, no. 5 (1993) : 495-502.http://dx.doi.org/10.1006/cbir.1993.1090
---------- MLA ----------
Gomez, M.L., Resnicoff, M., Medrano, E.E., Tellez-Inon, M.T. "The increase in cytosolic levels of protein kinase C precedes the growth factor requirements during the transition stem cells to differentiated progeny in the MCF-7 breast tumor cells." Cell Biology International, vol. 17, no. 5, 1993, pp. 495-502.http://dx.doi.org/10.1006/cbir.1993.1090
---------- VANCOUVER ----------
Gomez, M.L., Resnicoff, M., Medrano, E.E., Tellez-Inon, M.T. The increase in cytosolic levels of protein kinase C precedes the growth factor requirements during the transition stem cells to differentiated progeny in the MCF-7 breast tumor cells. Cell Biol. Int. 1993;17(5):495-502.http://dx.doi.org/10.1006/cbir.1993.1090
