Artículo

Giordano, M.; Croci, D.O.; Rabinovich, G.A. "Galectins in hematological malignancies" (2013) Current Opinion in Hematology. 20(4):327-335
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Abstract:

Purpose of Review: Galectins are a family of lectin molecules that have emerged as key players in inflammation and tumor progresssion by displaying intracellular and extracellular activities. This review describes the recent advances on the role of galectins in hematological neoplasms. RECENT FINDINGS: Galectin-1 and galectin-3 are the best studied galectins in oncohematology. Increased expression of galectin-1 has been associated with tumor progression in HodgkinÊs lymphoma and chronic lymphocytic leukemia, whereas galectin-3 plays a supporting role in chronic myelogenous leukemia and multiple myeloma. Functional studies have assigned a key role for galectin-1 as a negative regulator of T-cell immunity in HodgkinÊs lymphoma and cutaneous T-cell lymphoma. Of therapeutic interest is the development of agents with the capacity to interfere with galectin functions. SUMMARY: Current knowledge indicates a key role for galectins in hematological neoplasms by favoring the growth and survival of tumor cells and facilitating tumor immune escape. Intervention using specific galectin inhibitors is emerging as an attractive therapeutic option to alter the course of these malignancies. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Registro:

Documento: Artículo
Título:Galectins in hematological malignancies
Autor:Giordano, M.; Croci, D.O.; Rabinovich, G.A.
Filiación:Laboratorio de Inmunología Oncológica, Instituto de Investigaciones Médicas (IMEX/CONICET), Academia Nacional de Medicina, Buenos Aires, Argentina
Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490 (1428), Buenos Aires, Argentina
Laboratorio de Glicómica Funcional, Departamento de Química Biológica, Universidad de Buenos Aires, Argentina , These Authors Contributed Equally to This Work., Buenos Aires, Argentina
Palabras clave:Galectins; Hodgkin?s lymphoma; Lymphomas; Myeloma; Non-Hodgkin?s lymphoma; ecalectin; galectin; galectin 1; galectin 10; galectin 11; galectin 12; galectin 13; galectin 14; galectin 15; galectin 2; galectin 3; galectin 4; galectin 5; galectin 6; galectin 7; latent membrane protein 1; latent membrane protein 2; messenger RNA; mitogen activated protein kinase 1; mitogen activated protein kinase 3; transcription factor AP 1; unclassified drug; acute granulocytic leukemia; angiogenesis; cellular immunity; chronic lymphatic leukemia; chronic myeloid leukemia; cutaneous T cell lymphoma; dendritic cell; disease association; follicular lymphoma; hematologic malignancy; Hodgkin disease; human; large cell lymphoma; lymph node; lymphoproliferative disease; multiple myeloma; priority journal; protein expression; review; signal transduction; spleen; T lymphocyte; tumor invasion; Galectins; Hematologic Neoplasms; Humans; Immunity, Cellular; Neoplasm Proteins; T-Lymphocytes
Año:2013
Volumen:20
Número:4
Página de inicio:327
Página de fin:335
DOI: http://dx.doi.org/10.1097/MOH.0b013e328362370f
Título revista:Current Opinion in Hematology
Título revista abreviado:Curr. Opin. Hematol.
ISSN:10656251
CODEN:COHEF
CAS:galectin 1, 258495-34-0; galectin 3, 208128-56-7; latent membrane protein 1, 151441-67-7; mitogen activated protein kinase 1, 137632-08-7; mitogen activated protein kinase 3, 137632-07-6; Galectins; Neoplasm Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10656251_v20_n4_p327_Giordano

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Citas:

---------- APA ----------
Giordano, M., Croci, D.O. & Rabinovich, G.A. (2013) . Galectins in hematological malignancies. Current Opinion in Hematology, 20(4), 327-335.
http://dx.doi.org/10.1097/MOH.0b013e328362370f
---------- CHICAGO ----------
Giordano, M., Croci, D.O., Rabinovich, G.A. "Galectins in hematological malignancies" . Current Opinion in Hematology 20, no. 4 (2013) : 327-335.
http://dx.doi.org/10.1097/MOH.0b013e328362370f
---------- MLA ----------
Giordano, M., Croci, D.O., Rabinovich, G.A. "Galectins in hematological malignancies" . Current Opinion in Hematology, vol. 20, no. 4, 2013, pp. 327-335.
http://dx.doi.org/10.1097/MOH.0b013e328362370f
---------- VANCOUVER ----------
Giordano, M., Croci, D.O., Rabinovich, G.A. Galectins in hematological malignancies. Curr. Opin. Hematol. 2013;20(4):327-335.
http://dx.doi.org/10.1097/MOH.0b013e328362370f