Abstract:
This review chapter presents a statistical point of view to microarray experiments with the purpose of understanding the apparent contradictions that often appear in relation to their results. We give a brief introduction of molecular biology for nonspecialists. We describe microarray experiments from their construction and the biological principles the experiments rely on, to data acquisition and analysis. The role of epidemiological approaches and sample size considerations are also discussed. © Springer Science+Business Media New York 2013.
Registro:
Documento: |
Artículo
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Título: | Where statistics and molecular microarray experiments biology meet |
Autor: | Kelmansky, D.M. |
Filiación: | Instituto de Cálculo, Ciudad Universitaria, Buenos Aires, Argentina
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Palabras clave: | Calibration; Epidemiology; Image processing; Microarray experiments; Statistics; DNA; nucleotide derivative; oligonucleotide; polynucleotide; RNA; article; calibration; data analysis; DNA denaturation; DNA hybridization; DNA polymorphism; DNA structure; eukaryotic cell; experiment; gene expression; human; human genome; image analysis; microarray analysis; molecular biology; observational study; priority journal; reverse transcription; RNA isolation; RNA splicing; RNA structure; sample size; algorithm; comparative genomic hybridization; DNA microarray; gene expression profiling; image processing; methodology; nucleotide sequence; review; statistical analysis; Algorithms; Base Sequence; Calibration; Comparative Genomic Hybridization; Data Interpretation, Statistical; Gene Expression Profiling; Humans; Image Processing, Computer-Assisted; Oligonucleotide Array Sequence Analysis |
Año: | 2013
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Volumen: | 972
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Página de inicio: | 15
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Página de fin: | 35
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DOI: |
http://dx.doi.org/10.1007/978-1-60327-337-4_2 |
Título revista: | Methods in Molecular Biology
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Título revista abreviado: | Methods Mol. Biol.
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ISSN: | 10643745
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CAS: | DNA, 9007-49-2; RNA, 63231-63-0
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10643745_v972_n_p15_Kelmansky |
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Citas:
---------- APA ----------
(2013)
. Where statistics and molecular microarray experiments biology meet. Methods in Molecular Biology, 972, 15-35.
http://dx.doi.org/10.1007/978-1-60327-337-4_2---------- CHICAGO ----------
Kelmansky, D.M.
"Where statistics and molecular microarray experiments biology meet"
. Methods in Molecular Biology 972
(2013) : 15-35.
http://dx.doi.org/10.1007/978-1-60327-337-4_2---------- MLA ----------
Kelmansky, D.M.
"Where statistics and molecular microarray experiments biology meet"
. Methods in Molecular Biology, vol. 972, 2013, pp. 15-35.
http://dx.doi.org/10.1007/978-1-60327-337-4_2---------- VANCOUVER ----------
Kelmansky, D.M. Where statistics and molecular microarray experiments biology meet. Methods Mol. Biol. 2013;972:15-35.
http://dx.doi.org/10.1007/978-1-60327-337-4_2