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Abstract:

The genus Alternaria includes more than 250 species. The traditional methods for identification of Alternaria species are based on morphological characteristics of the reproductive structures and sporulation patterns under controlled culture conditions. Cladistics analyses of “housekeeping genes” commonly used for other genera, failed to discriminate among the small-spored Alternaria species. The development of molecular methods achieving a better agreement with morphological differences is still needed. The production of secondary metabolites has also been used as a means of classification and identification. Alternaria spp. can produce a wide variety of toxic metabolites. These metabolites belong principally to three different structural groups: (1) the dibenzopyrone derivatives, alternariol (AOH), alternariol monomethyl ether (AME), and altenuene (ALT); (2) the perylene derivative altertoxins (ATX-I, ATX-II, and ATX II); and (3) the tetramic acid derivative, tenuazonic acid (TeA). TeA, AOH, AME, ALT, and ATX-I are the main. Certain species in the genus Alternaria produce host-specific toxins (HSTs) that contribute to their pathogenicity and virulence. Alternaria species are plant pathogens that cause spoilage of agricultural commodities with consequent mycotoxin accumulation and economic losses. Vegetable foods infected by Alternaria rot could introduce high amounts of these toxins to the human diet. More investigations on the toxic potential of these toxins and their hazard for human consumption are needed to make a reliable risk assessment of dietary exposure. © Springer Science+Business Media LLC 2017.

Registro:

Documento: Artículo
Título:Alternaria species and their associated mycotoxins
Autor:Pinto, V.E.F.; Patriarca, A.
Filiación:Laboratorio de Microbiología de Alimentos, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Pab. II- 3° Piso- Ciudad Universitaria, Universidad de Buenos Aires, Buenos Aires, 1428, Argentina
Palabras clave:Alternaria species; Fruits; Grains; Mycotoxins; Taxonomy; Vegetables; alternariol; alternariol monomethyl ether; altertoxin; mycotoxin; perylene; tentoxin; tenuazonic acid; tetramic acid derivative; unclassified drug; mycotoxin; Alternaria; apple; cereal; chemotaxonomy; citrus fruit; food; fungal gene; fungal virulence; fungus culture; fungus identification; host; housekeeping gene; metabolite; molecular phylogeny; morphological trait; nonhuman; plant disease; sporogenesis; tomato; Alternaria; animal; animal food; classification; food contamination; food safety; genetics; host pathogen interaction; human; metabolism; metabolome; metabolomics; microbiology; plant; procedures; secondary metabolism; Alternaria; Animal Feed; Animals; Food Contamination; Food Safety; Host-Pathogen Interactions; Humans; Metabolome; Metabolomics; Mycotoxins; Plants; Secondary Metabolism
Año:2017
Volumen:1542
Página de inicio:13
Página de fin:32
DOI: http://dx.doi.org/10.1007/978-1-4939-6707-0_2
Título revista:Methods in Molecular Biology
Título revista abreviado:Methods Mol. Biol.
ISSN:10643745
CAS:alternariol, 641-38-3; perylene, 198-55-0; tenuazonic acid, 610-88-8, 75652-74-3; Mycotoxins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10643745_v1542_n_p13_Pinto

Referencias:

  • Ellis, M.B., (1971) Dematiaceous Hyphomycetes, , Commonwealth Mycological Institute, Kew
  • Ellis, M.B., (1976) More Dematiaceous Hyphomycetes, , Commonwealth Mycological Institute, Kew
  • Simmons, E.G., Alternaria taxonomy: Current status, viewpoint, challenge (1992) Alternaria Biology, Plant Diseases and Metabolites, pp. 1-35. , Chelkowski J, Visconti A, Elsevier Science Publishers, Amsterdam
  • Simmons, E.G., (2007) Alternaria. an Identification Manual, , CBS Fungal Biodiversity Centre, Utrecht
  • Samson, R.A., Houbraken, J., Thrane, U., (2010) Food and Indoor Fungi, , CBS-KNAW Fungal Biodiversity Centre, Utrecht
  • Patriarca, A., Vaamonde, G., Pinto, V.F., Alternaria (2014) Encyclopedia of Food Microbiology, 1, pp. 54-60. , Batt CA, Tortorello ML, Academic Press, Elsevier, London
  • Lawrence, D.P., Gannibal, P.B., Peever, T.L., The sections of Alternaria: Formalizing species-group concepts (2013) Mycologia, 105 (3), pp. 530-546
  • Nees Von Esenbeck, C.G., (1816) Das System Der Pilze Und Schwämme, , Stahelschen Buchhandlung, Würzburg
  • Elliott, J.A., Taxonomic characters of the genera Alternaria and Macrosporium (1917) Am J Bot, 4, pp. 439-476
  • Wiltshire, S.P., The foundation species of Alternaria and Macrosporium (1933) Trans Br Mycol Soc, 18, pp. 135-160
  • Neergaard, P., (1945) Danish Species of Alternaria and Stemphylium, , Oxford University Press, London
  • Joly, P., (1964) Le Genre Alternaria. Encyclopedie Mycologique, , P. Lechevalier, Paris
  • Simmons, E.G., Typification of Alternaria, Stemphylium, and Ulocladium (1967) Mycologia, 59, pp. 67-92
  • Pryor, B.M., Gilbertson, R.L., Molecular phylogenetic relationships amongst Alternaria species and related fungi based upon analysis of nuclear ITS and mt SSU rDNA sequences (2000) Mycol Res, 104 (11), pp. 1312-1321
  • Simmons, E.G., Roberts, R.G., Alternaria themes and variations (73) (1993) Mycotaxon, 48, pp. 109-140
  • Simmons, E.G., Alternaria themes and variations (1-6) (1981) Mycotaxon, 13, pp. 16-34
  • Simmons, E.G., Alternaria themes and variations (63-72) (1993) Mycotaxon, 48, pp. 91-107
  • Simmons, E.G., Alternaria themes and variations (226-235). Classification of citrus pathogens (1999) Mycotaxon, 70, pp. 263-323
  • Simmons, E.G., Alternaria themes and variations (236-243). Host-specific toxin producers (1999) Mycotaxon, 70, pp. 325-369
  • Simmons, E.G., Alternaria themes and variations (310-335). Species on Malvaceae (2003) Mycotaxon, 88, pp. 163-217
  • Nishimura, S., Sugihara, M., Kohmoto, K., Otani, H., Two different phases in pathogenicity of the Alternaria pathogen causing black spot disease of Japanese pear (1978) J Fac Agric Tottori Univ, 13, pp. 1-10
  • Rotem, J., (1994) The Genus Alternaria: Biology, Epidemiology, and Pathogenicity, , APS Press, St Paul
  • Andersen, B., Hansen, M.E., Smedsgaard, J., Automated and unbiased image analyses as tools in phenotypic classification of smallspored Alternaria spp (2005) Phytopathology, 95, pp. 1021-1029
  • Andrew, M., Peever, T.L., Pryor, B.M., An expanded multilocus phylogeny does not resolve morphological species within the smallspored Alternaria species complex (2009) Mycologia, 101 (1), pp. 95-109
  • Kusaba, M., Tsuge, T., Phylogeny of Alternaria fungi known to produce hostspecific toxins on the basis of variation in internal transcribed spacers of ribosomal DNA (1995) Curr Genet, 28, pp. 491-498
  • Weir, T.L., Huff, D.R., Christ, B.J., Peter Romaine, C., RAPD-PCR analysis of genetic variation among isolates of Alternaria solani and Alternaria alternata from potato and tomato (1998) Mycologia, 90, pp. 813-821
  • Pryor, B.M., Michailides, T.J., Morphological, pathogenic, and molecular characterization of Alternaria isolates associated with alternaria late blight of pistachio (2002) Phytopathology, 92 (4), pp. 406-416
  • Roberts, R.G., Reymond, S.T., Ersen, B., RAPD fragment pattern analysis and morphological segregation of small-spored Alternaria species and species groups (2000) Mycol Res, 104 (2), pp. 151-160
  • Peever, T.L., Su, G., Carpenter-Boggs, L., Timmer, L.W., Molecular systematics of citrusassociated Alternaria species (2004) Mycologia, 96, pp. 119-134
  • Woudenberg, J., Groenewald, J.Z., Binder, M., Crous, P.W., Alternaria redefined (2013) Stud Mycol, 75, pp. 171-212
  • Stewart, J.E., Timmer, L.W., Lawrence, C.B., Pryor, B.M., Peever, T.L., Discord between morphological and phylogenetic species boundaries: Incomplete lineage sorting and recombination results in fuzzy species boundaries in an asexual fungal pathogen (2014) BMC Evol Biol, 14 (1), p. 38
  • Frisvad, J.C., Ersen, B., Thrane, U., The use of secondary metabolite profiling in chemotaxonomy of filamentous fungi (2008) Mycol Res, 112, pp. 231-240
  • Larsen, T.O., Frisvad, J.C., A simple method for collection of volatile metabolites from fungi based on diffusive sampling from Petri dishes (1994) J Microbiol Methods, 19, pp. 297-305
  • Nielsen, K.F., Smedsgaard, J., Fungal metabolite screening: Database of 474 mycotoxins and fungal metabolites for dereplication by standardised liquid chromatography- UV-mass spectrometry methodology (2003) J Chromatogr A, 1002, pp. 111-136
  • Smedsgaard, J., Nielsen, J., Metabolite profiling of fungi and yeast: From phenotype to metabolome by MS and informatics (2005) J Exp Bot, 56, pp. 273-286
  • Andersen, B., Thrane, U., Differentiation of Alternaria infectoria and Alternaria alternata based on morphology, metabolite profiles, and cultural characteristics (1996) Can J Microbiol, 42, pp. 685-689
  • Andersen, B., Krøger, E., Roberts, R.G., Chemical and morphological segregation of Alternaria alternata (2001) A. Gaisen and A. Longipes. Mycol Res, 105 (3), pp. 291-299
  • Andersen, B., Krøger, E., Roberts, R.G., Chemical and morphological segregation of Alternaria arborescens (2002) A. Infectoria and A. Tenuissima Species-Groups. Mycol Res, 106 (2), pp. 170-182
  • Andersen, B., Dongo, A., Pryor, B.M., Secondary metabolite profiling of Alternaria dauci, A. Porri, A. solani, and A. tomatophila (2008) Mycol Res, 112, pp. 241-250
  • Andersen, B., Sørensen, J.L., Nielsen, K.F., A polyphasic approach to the taxonomy of the Alternaria infectoria species-group (2009) Fungal Genet Biol, 46, pp. 642-656
  • Polizzotto, R., Ersen, B., Martini, M., A polyphasic approach for the characterization of endophytic Alternaria strains isolated from grapevines (2012) J Microbiol Methods, 88, pp. 162-171
  • Ostry, V., Alternaria mycotoxins: An overview of chemical characterization, producers, toxicity, analysis and occurrence in foods (2008) World Mycotoxin J, 1 (2), pp. 175-188
  • Lou, J., Fu, L., Peng, Y., Zhou, L., Metabolites from Alternaria fungi and their bioactivities (2013) Molecules, 18, pp. 5891-5935
  • Liu, G.T., Qian, Y.Z., Zhang, P., Relationships between Alternaria alternata and oesophageal cancer (1991) IARC Sci Publ, 105, pp. 258-262
  • Liu, G.T., Qian, Y.Z., Zhang, P., Dong, W.H., Etiologic role of Alternaria alternata in human esophageal cancer (1992) Chin Med J, 105, pp. 394-400
  • Brugger, E.M., Wagner, J., Schumacher, D.M., Mutagenicity of the mycotoxin alternariol in cultured mammalian cells (2006) Toxicol Lett, 164, pp. 221-230
  • Tiemann, U., Tomek, W., Schneider, F., The mycotoxins alternariol and alternariol methyl ether negatively affect progesterone synthesis in porcine granulosa cells in vitro (2009) Toxicol Lett, 86, pp. 139-145
  • Lehmann, L., Wagner, J., Metzler, M., Estrogenic and clastogenic potential of the mycotoxin alternariol in cultured mammalian cells (2006) Food Chem Toxicol, 44, pp. 398-408
  • Soulhaug, A., Vines, L.L., Ivanova, L., Mechanisms involved in alternariol-induced cell cycle arrest (2011) Mutat Res, 738-739, pp. 1-11
  • Fehr, M., Pahlke, G., Fritz, J., Alternariol acts as a topoisomerase poison, preferentially affecting the II isoform (2009) Mol Nutr Food Res, 53, pp. 441-451
  • Siegel, D., Feist, M., Proske, M., Degradation of the Alternaria mycotoxins alternariol, alternariol monomethyl ether, and altenuene upon bread baking (2010) J Agric Food Chem, 58, pp. 9622-9630
  • Wang, Y., Yang, M., Wang, X., Bioactive metabolites from the endophytic fungus Alternaria alternata (2014) Fitoterapia, 99, pp. 153-158
  • Schrader, T.J., Cherry, W., Soper, K., Examination of Alternaria alternata mutagenicity and effects of nitrosylation using the Ames Salmonella test (2001) Teratog Carcinog Mutagen, 21, pp. 261-274
  • Schrader, T.J., Cherry, W., Soper, K., Langlois, I., Further examination of the effects of nitrosylation on Alternaria alternata mycotoxin mutagenicity in vitro (2006) Mutat Res, 606, pp. 61-71
  • Fleck, S.C., Burkhardt, B., Pfeiffer, E., Metzler, M., Alternaria toxins: Altertoxin II is a much stronger mutagen and DNA strand breaking mycotoxin than alternariol and its methyl ether in cultured mammalian cells (2012) Toxicol Lett, 214, pp. 27-32
  • Fleck, S., Pfeiffer, E., Podlech, J., Metzler, M., Epoxide reduction to an alcohol: A novel metabolic pathway for perylene quinonetype Alternaria mycotoxins in mammalian cells (2014) Chem Res Toxicol, 27, pp. 247-253
  • Logrieco, A., Moretti, A., Solfrizzo, M., Alternaria toxins and plant diseases: An overview of origin, occurrence and risks (2009) World Mycotoxin J, 2, pp. 129-140
  • Yekeler, H.B., Bitmiş, K., Özçelık, N., Analysis of toxic effects of Alternaria toxins on esophagus of mice by light and electron microscopy (2001) Toxicol Pathol, 29 (4), pp. 492-497
  • Zhou, B., Qiang, S., Environmental, genetic and cellular toxicity of tenuazonic acid isolated from Alternaria alternata (2008) Afr J Biotechnol, 7 (8), pp. 1151-1156
  • Akimitsu, K., Tsuge, T., Kodama, M., Alternaria host-selective toxins: Determinant factors of plant disease (2014) J Gen Plant Pathol, 80, pp. 109-122
  • Tsuge, T., Harimoto, Y., Akimitsu, K., Host-selective toxins produced by the plant pathogenic fungus Alternaria alternata (2013) FEMS Microbiol Rev, 37, pp. 44-66
  • Akagi, Y., Akamatsu, H., Otani, H., Kodama, M., Horizontal chromosome transfer, a mechanism for the evolution and differentia-tion of a plant-pathogenic fungus (2009) Eukaryot Cell, 8, pp. 1732-1738
  • Akagi, Y., Taga, M., Yamamoto, M., Chromosome constitution of hybrid strains constructed by protoplast fusion between the tomato and strawberry pathotypes of Alternaria alternata (2009) J Gen Plant Pathol, 75, pp. 101-109
  • Duke, S., Dayan, F., Modes of action of microbially-produced phytotoxins (2011) Toxins, 3, pp. 1038-1064
  • Müller, M., Korn, U., Alternaria mycotoxins in wheat—A 10 years survey in the Northeast of Germany (2013) Food Control, 34, pp. 191-197
  • Azcarate, M.P., Patriarca, A., Terminiello, L., Fernández Pinto, V., Alternaria toxins in wheat during the 2004 to 2005 Argentinean harvest (2008) J Food Prot, 71, pp. 1262-1265
  • Zachariasova, M., Dzuman, Z., Veprikova, Z., Occurrence of multiple mycotoxins in European feeding stuffs, assessment of dietary intake by farm animals (2014) Anim Feed Sci Technol, 193, pp. 124-140
  • Oviedo, M.S., Barros, G., Chulze, S., Ramirez, M.L., Natural occurrence of alternariol and alternariol monomethyl ether in soya beans (2012) Mycotoxin Res, 28, pp. 169-174
  • Noser, J., Schneider, P., Rother, M., Schmutz, H., Determination of six Alternaria toxins with UPLC-MS/MS and their occurrence in tomatoes and tomato products from the Swiss market (2011) Mycotoxin Res, 27, pp. 265-271
  • Prelle, A., Spadaro, D., Garibaldi, A., Gullino, M.L., A new method for detection of five Alternaria toxins in food matrices based on LC-APCI-MS (2013) Food Chem, 140, pp. 161-167
  • Zhao, K., Shao, B., Yang, D., Li, F., Natural occurrence of four Alternaria mycotoxins in tomato and citrus-based foods in China (2015) J Agric Food Chem, 63, pp. 343-348
  • Terminiello, L., Patriarca, A., Pose, G., Fernandez Pinto, V., Occurrence of alternariol, alternariol monomethyl ether and tenuazonic acid in Argentinean tomato puree (2006) Mycotoxin Res, 22 (4), pp. 236-240
  • Asam, S., Konitzer, K., Schieberle, P., Rychlik, M., Stable isotope dilution assays of alternariol and alternariol monomethyl ether in beverages (2009) J Agric Food Chem, 57, pp. 5152-5160
  • Scientific opinion on the risks for animal and public health related to the presence of Alternaria toxins in feed and food (2011) EFSA J, 9 (10), p. 2407. , 97 pp)
  • Scott, P.M., Lawrence, G.A., Lau, B.P., Analysis of wines, grape juices and cranberry juices for Alternaria toxins (2006) Mycotoxin Res, 22 (2), pp. 142-147
  • Mikusova, P., Santin, A., Ritieni, A., Berries contamination by microfungi in Slovakia vineyard regions: Impact of climate conditions on microfungi biodiversity (2012) Rev Iberoam Micol, 29 (3), pp. 126-131
  • Pose, G., Patriarca, A., Kyanko, V., Water activity and temperature effects on mycotoxin production by Alternaria alternata on a synthetic tomato medium (2010) Int J Food Microbiol, 142, pp. 348-353
  • Robiglio, A.L., Lopez, S.E., Mycotoxin production by Alternaria alternata strains isolated from red delicious apples in Argentina (1995) Int J Food Microbiol, 24, pp. 413-417
  • Barkai-Golan, R., Paster, N., Mouldy fruits and vegetables as a source of mycotoxins: Part 1 (2008) World Mycotoxin J, 1, pp. 147-159
  • Patriarca, A., Azcarate, M.P., Terminiello, L., Fernández Pinto, V., Mycotoxin production by Alternaria strains isolated from Argentinean wheat (2007) Int J Food Microbiol, 119, pp. 684-695
  • Christensen, K.B., van Klink, J.W., Weavers, R.T., Novel chemotaxonomic markers of the Alternaria infectoria species-group (2005) J Agric Food Chem, 53, pp. 9431-9435

Citas:

---------- APA ----------
Pinto, V.E.F. & Patriarca, A. (2017) . Alternaria species and their associated mycotoxins. Methods in Molecular Biology, 1542, 13-32.
http://dx.doi.org/10.1007/978-1-4939-6707-0_2
---------- CHICAGO ----------
Pinto, V.E.F., Patriarca, A. "Alternaria species and their associated mycotoxins" . Methods in Molecular Biology 1542 (2017) : 13-32.
http://dx.doi.org/10.1007/978-1-4939-6707-0_2
---------- MLA ----------
Pinto, V.E.F., Patriarca, A. "Alternaria species and their associated mycotoxins" . Methods in Molecular Biology, vol. 1542, 2017, pp. 13-32.
http://dx.doi.org/10.1007/978-1-4939-6707-0_2
---------- VANCOUVER ----------
Pinto, V.E.F., Patriarca, A. Alternaria species and their associated mycotoxins. Methods Mol. Biol. 2017;1542:13-32.
http://dx.doi.org/10.1007/978-1-4939-6707-0_2