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Referencias:

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• For example, in experiments where different types of exogenous calcium buffers are added into the cytoplasm of cells, there could be a dramatic difference in the spatiotemporal organization according to the buffer’s mobility. This fact has been clearly demonstrated in experiments done in oocytes, in which a transition from global calcium wave propagation to localized calcium release events (named puffs) could be induced by the addition of one type of mobile buffer (EGTA) but not of another one (BAPTA) c35; We will refer to the activator-inhibitor type in the rest of the paper, but exactly the same results hold for the other case; Sneyd, J., Dale, P., Duffy, A., (1998) SIAM (Soc. Ind. Appl. Math.) J. Appl. Math., 58, p. 4
• Smith, G., ; Strier, D.E., Dawson, S.P., ; This occurs, for example, in the case of cytosolic calcium dynamics, where, although the details of the interactions of calcium with specific membrane receptors are not fully known, yet it is known that buffers dramatically reduce the concentration of free calcium in the cytosol c29 and affect its diffusivity c15; This situation arises in biochemistry, where the same enzyme might bind, in different reaction steps, both, the inhibitor and the activator of a metabolic pathway c29; For example, the CIMA reaction is a particular case, where the starch molecules interact only with iodide c9. This case is also relevant in biochemistry, with the CA representing two different buffers or enzymes; Sec. 3 we analyze a particular example of this procedure. See Ref. for a general treatment; Keener, J., Sneyd, J., (1998) Mathematical Physiology, , Springer-Verlag
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• This was first recognized in Ref; Goodwin, B.C., Murray, J.D., Baldwin, D., ; Michailova, A., DelPrincipe, F., Egger, M., Niggli, E., (2002) Biophys. J., 83, p. 3134
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