Artículo

Buzaleh, A.M.; de Salamanca, R.E.; Del Carmen Batlle, A.M. "Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?" (1992) Journal of Pharmacological and Toxicological Methods. 28(4):191-197
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Abstract:

The effects of isoflurane, a commonly used volatile anesthetic, on the activity of some haem enzymes in liver, kidney, and blood, and glucose content in liver and blood were studied. Mice were injected with different doses of the drug (0.5-6 mL/kg) and killed at varying intervals after injection (5-240 min). Within this dose range, optimal effects on alteration of haem metabolism were obtained at 2 mL/kg. The time-response profile for each enzyme was different. Blood porphobilinogenase (PBGase) and deaminase showed lower activities 20 min after anesthesia. This diminution coupled with the induction of δ-aminolevulinate synthetase activity observed soon after anesthesia (5 min) would fit well with the expected biochemical changes occurring in acute intermittent porphyria, indicating that this may be a suitable animal model for this disease. © 1992.

Registro:

Documento: Artículo
Título:Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?
Autor:Buzaleh, A.M.; de Salamanca, R.E.; Del Carmen Batlle, A.M.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias (CONICET-FCEN, UBA), Ciudad Universitaria, Pabellón II, Buenos Aires, Argentina
Unidad de Porforias, Departamento de Medicina Interna, Hospital Clinico de San Carlos, Madrid, Spain
Palabras clave:Acute Intermittent Porphyria; Anesthesia; Isoflurane; 5 aminolevulinate synthase; glucose; heme oxygenase; inhalation anesthetic agent; isoflurane; porphobilinogen deaminase; porphobilinogenase; unclassified drug; acute intermittent porphyria; anesthesia; animal experiment; animal model; animal tissue; article; blood; controlled study; dose time effect relation; enzyme activity; glucose metabolism; heme synthesis; intraperitoneal drug administration; kidney; liver; mouse; nonhuman; priority journal; Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Glucose; Isoflurane; Kidney; Liver; Mice; Porphyria, Acute Intermittent; Support, Non-U.S. Gov't
Año:1992
Volumen:28
Número:4
Página de inicio:191
Página de fin:197
DOI: http://dx.doi.org/10.1016/1056-8719(92)90003-J
Título revista:Journal of Pharmacological and Toxicological Methods
Título revista abreviado:J. Pharmacol. Toxicol. Methods
ISSN:10568719
CODEN:JPTME
CAS:5 aminolevulinate synthase, 9037-14-3; glucose, 50-99-7, 84778-64-3; heme oxygenase, 9059-22-7; isoflurane, 26675-46-7; porphobilinogen deaminase, 9036-47-9, 9074-91-3; porphobilinogenase, 9055-40-7; Glucose, 50-99-7; Isoflurane, 26675-46-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10568719_v28_n4_p191_Buzaleh

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Citas:

---------- APA ----------
Buzaleh, A.M., de Salamanca, R.E. & Del Carmen Batlle, A.M. (1992) . Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?. Journal of Pharmacological and Toxicological Methods, 28(4), 191-197.
http://dx.doi.org/10.1016/1056-8719(92)90003-J
---------- CHICAGO ----------
Buzaleh, A.M., de Salamanca, R.E., Del Carmen Batlle, A.M. "Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?" . Journal of Pharmacological and Toxicological Methods 28, no. 4 (1992) : 191-197.
http://dx.doi.org/10.1016/1056-8719(92)90003-J
---------- MLA ----------
Buzaleh, A.M., de Salamanca, R.E., Del Carmen Batlle, A.M. "Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?" . Journal of Pharmacological and Toxicological Methods, vol. 28, no. 4, 1992, pp. 191-197.
http://dx.doi.org/10.1016/1056-8719(92)90003-J
---------- VANCOUVER ----------
Buzaleh, A.M., de Salamanca, R.E., Del Carmen Batlle, A.M. Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?. J. Pharmacol. Toxicol. Methods. 1992;28(4):191-197.
http://dx.doi.org/10.1016/1056-8719(92)90003-J