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Abstract:

Stress is known to have a critical impact on memory processes. In the present work, we focus on the effects of an acute stress event closely associated to an unrelated learning task. Here, we show that acute stress (elevated platform [EP] session) experienced 1 hr after a weak spatial object recognition (SOR) training, which only induces a short-term memory (STM), promoted the formation of SOR-long term memory (SOR-LTM) in rats. The effect induced by stress was dependent on the activation of glucocorticoid- and mineralocorticoid-receptors, brain-derived neurotrophic factor (BDNF) and protein synthesis in the dorsal hippocampus. In contrast, EP after a strong SOR impaired SOR-LTM probably by interfering with the use of necessary resources. Moreover, we show that the EP session before training induced anterograde interference, which it was not reversed by a subsequent exposure to an open field. Our findings provide novel insights into the impact of stress on LTM formation in rodents and they are discussed under the behavioral analogue of the synaptic tagging and capture hypothesis. © 2018 Wiley Periodicals, Inc.

Registro:

Documento: Artículo
Título:Spatial object recognition memory formation under acute stress
Autor:Lopes da Cunha, P.; Villar, M.E.; Ballarini, F.; Tintorelli, R.; Ana María Viola, H.
Filiación:Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
Instituto de Biología Celular y Neurociencias “Dr Eduardo De Robertis” (IBCN), CONICET—Universidad de Buenos Aires, Buenos Aires, Argentina
Departamento de Fisiología, Biología Molecular y Celular “Dr. Hector Maldonado” (FBMC), Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina
Palabras clave:elevated platform; hippocampus; long-term memory; spatial object recognition; synaptic tagging
Año:2018
DOI: http://dx.doi.org/10.1002/hipo.23037
Título revista:Hippocampus
Título revista abreviado:Hippocampus
ISSN:10509631
CODEN:HIPPE
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10509631_v_n_p_LopesdaCunha

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Citas:

---------- APA ----------
Lopes da Cunha, P., Villar, M.E., Ballarini, F., Tintorelli, R. & Ana María Viola, H. (2018) . Spatial object recognition memory formation under acute stress. Hippocampus.
http://dx.doi.org/10.1002/hipo.23037
---------- CHICAGO ----------
Lopes da Cunha, P., Villar, M.E., Ballarini, F., Tintorelli, R., Ana María Viola, H. "Spatial object recognition memory formation under acute stress" . Hippocampus (2018).
http://dx.doi.org/10.1002/hipo.23037
---------- MLA ----------
Lopes da Cunha, P., Villar, M.E., Ballarini, F., Tintorelli, R., Ana María Viola, H. "Spatial object recognition memory formation under acute stress" . Hippocampus, 2018.
http://dx.doi.org/10.1002/hipo.23037
---------- VANCOUVER ----------
Lopes da Cunha, P., Villar, M.E., Ballarini, F., Tintorelli, R., Ana María Viola, H. Spatial object recognition memory formation under acute stress. Hippocampus. 2018.
http://dx.doi.org/10.1002/hipo.23037