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Successful mammalian pregnancy relies upon acceptance of a semi-allogeneic fetus by the maternal immune system. Lessons learned from studies on protective immunity to microbial infections and tumours, prevention of autoimmunity, and allograft rejection have contributed to delineate the mechanisms leading to T-cell tolerance at the fetomaternal interface. Recent observations highlight the contribution of galectins, a family of endogenous glycan-binding proteins, to critical biological events occurring during mammalian gestation, including immune cell tolerance, inflammation, implantation, and angiogenesis. These multifunctional lectins can hierarchically control a cascade of immunoregulatory events including the expansion, recruitment, and function of regulatory T cells, the promotion of tolerogenic dendritic cells, and the execution of T-cell death programs. In addition, galectins can control cell adhesion and signaling events critical for implantation and are involved in fundamental processes linking tissue hypoxia to angiogenesis. In an attempt to integrate the regulatory roles of galectins to immunological and vascular programs operating during pregnancy. Here we outline the regulated expression and function of individual members of the galectin family within the fetoplacental unit and their biological implications for the development and preservation of successful pregnancies. © 2013 John Wiley & Sons A/S.


Documento: Artículo
Título:'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface
Autor:Blidner, A.G.; Rabinovich, G.A.
Filiación:Instituto de Oncología Ángel H. Roffo, Universidad de Buenos Aires, Buenos Aires, Argentina
Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
Laboratorio de Glicómica Funcional, IQUIBICEN-CONICET, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Angiogenesis; Fetomaternal tolerance; Galectins; Immune privilege; Implantation; Pregnancy; ecalectin; galectin; galectin 1; galectin 10; galectin 12; galectin 13; galectin 14; galectin 15; galectin 2; galectin 3; galectin 4; galectin 7; galectin 8; glycan; hypoxia inducible factor 1alpha; immunoglobulin enhancer binding protein; Janus kinase 2; lectin; unclassified drug; vasculotropin receptor 3; fetoplacental unit; homeostasis; human; nonhuman; pregnancy; priority journal; protein expression; protein function; review; Cell Adhesion; Cell Communication; Cell Hypoxia; Dendritic Cells; Embryo Implantation; Female; Fetus; Galectins; Humans; Immune Tolerance; Neovascularization, Physiologic; Pregnancy; Signal Transduction; T-Lymphocytes, Regulatory
Página de inicio:369
Página de fin:382
Título revista:American Journal of Reproductive Immunology
Título revista abreviado:Am. J. Reprod. Immunol.
CAS:galectin 1, 258495-34-0; galectin 3, 208128-56-7; galectin 8, 220452-97-1; Galectins


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---------- APA ----------
Blidner, A.G. & Rabinovich, G.A. (2013) . 'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface. American Journal of Reproductive Immunology, 69(4), 369-382.
---------- CHICAGO ----------
Blidner, A.G., Rabinovich, G.A. "'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface" . American Journal of Reproductive Immunology 69, no. 4 (2013) : 369-382.
---------- MLA ----------
Blidner, A.G., Rabinovich, G.A. "'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface" . American Journal of Reproductive Immunology, vol. 69, no. 4, 2013, pp. 369-382.
---------- VANCOUVER ----------
Blidner, A.G., Rabinovich, G.A. 'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface. Am. J. Reprod. Immunol. 2013;69(4):369-382.