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Abstract:

Pregnancy challenges immune cells and immunomodulatory circuits of the mother and the developing fetus to dynamically adapt to each other in an homeostatic and tolerant environment for fetal growth. This entails the coordination of multiple cellular processes all devoted to accommodate and nourish the fetus while protecting the mother from endogenous and exogenous threatens. From the earliest stages of pregnancy, several strategies to efficiently communicate immune and trophoblast cells within the interface or at a distance were identified and chemokines might act at on different targets through direct or indirect mechanisms. Here, we briefly review some mechanisms of T regulatory cell recruitment to the early maternal-placental interfaces to accomplish immunotolerance and homeostatic control and we discuss evidence on two locally released polypeptides, RANTES (regulated on activation, normal, T-cell expressed, and secreted) and vasoactive intestinal peptide (VIP), as novel contributors to the multiplicity of immune tolerant responses and uterine quiescence requirements. © 2013 John Wiley & Sons A/S.

Registro:

Documento: Artículo
Título:Tolerance Induction at the Early Maternal-Placental Interface Through Selective Cell Recruitment and Targeting by Immune Polypeptides
Autor:Pérez Leirós, C.; Ramhorst, R.
Filiación:Immunopharmacology Laboratory, School of Sciences, University of Buenos Aires, IQUIBICEN-CONICET, Buenos Aires, Argentina
Palabras clave:Chemokines; Maternal tolerance; Pregnancy; RANTES; Vasoactive intestinal peptide; chemokine receptor CCR1; chemokine receptor CCR3; chemokine receptor CCR5; chemokine receptor CXCR; inducible nitric oxide synthase; interleukin 10; interleukin 12; RANTES; tumor necrosis factor alpha; vasoactive intestinal polypeptide; cytokine release; homeostasis; immune response; immunological tolerance; maternal placental interface; molecular interaction; mother fetus relationship; priority journal; regulatory T lymphocyte; review; Th1 cell; Th17 cell; Chemokine CCL5; Chemokines; Female; Fetus; Humans; Immune Tolerance; Lymphocyte Activation; Placenta; Pregnancy; T-Lymphocytes, Regulatory; Trophoblasts; Vasoactive Intestinal Peptide
Año:2013
Volumen:69
Número:4
Página de inicio:359
Página de fin:368
DOI: http://dx.doi.org/10.1111/aji.12087
Título revista:American Journal of Reproductive Immunology
Título revista abreviado:Am. J. Reprod. Immunol.
ISSN:10467408
CODEN:AAJID
CAS:chemokine receptor CCR1, 265970-50-1; inducible nitric oxide synthase, 501433-35-8; interleukin 12, 138415-13-1; vasoactive intestinal polypeptide, 37221-79-7; CCL5 protein, human; Chemokine CCL5; Chemokines; Vasoactive Intestinal Peptide, 37221-79-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10467408_v69_n4_p359_PerezLeiros

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Citas:

---------- APA ----------
Pérez Leirós, C. & Ramhorst, R. (2013) . Tolerance Induction at the Early Maternal-Placental Interface Through Selective Cell Recruitment and Targeting by Immune Polypeptides. American Journal of Reproductive Immunology, 69(4), 359-368.
http://dx.doi.org/10.1111/aji.12087
---------- CHICAGO ----------
Pérez Leirós, C., Ramhorst, R. "Tolerance Induction at the Early Maternal-Placental Interface Through Selective Cell Recruitment and Targeting by Immune Polypeptides" . American Journal of Reproductive Immunology 69, no. 4 (2013) : 359-368.
http://dx.doi.org/10.1111/aji.12087
---------- MLA ----------
Pérez Leirós, C., Ramhorst, R. "Tolerance Induction at the Early Maternal-Placental Interface Through Selective Cell Recruitment and Targeting by Immune Polypeptides" . American Journal of Reproductive Immunology, vol. 69, no. 4, 2013, pp. 359-368.
http://dx.doi.org/10.1111/aji.12087
---------- VANCOUVER ----------
Pérez Leirós, C., Ramhorst, R. Tolerance Induction at the Early Maternal-Placental Interface Through Selective Cell Recruitment and Targeting by Immune Polypeptides. Am. J. Reprod. Immunol. 2013;69(4):359-368.
http://dx.doi.org/10.1111/aji.12087