Artículo

Fraccaroli, L.; Grasso, E.; Zeitler, E.; Lombardi, E.; Gogorza, S.; Etchepareborda, J.J.; Nagle, C.; Cortelezzi, M.; Leirós, C.P.; Ramhorst, R. "Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens" (2011) American Journal of Reproductive Immunology. 65(2):133-145
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Abstract:

Problem Fetal implantation enhances the production of essential growth factors such as LIF (leukaemia inhibitory factor), hence we investigated the contribution of maternal CD4 cells, activated by paternal or trophoblast antigens and its modulation by VIP (vasoactive intestinal peptide) and progesterone.Method of study We performed co cultures of trophoblast cells (Swan 71 cell line) or paternal antigens and PBMCs from patients with recurrent spontaneous abortions (RSA) and fertile women.Result Fertile-CD4+LIF+ cells were increased by VIP and progesterone in response to paternal and trophoblast antigens. Also MMP 9 activity was decreased and pSTAT3/STAT3 ratio was increased. RSA patients have decreased levels of LIF expression which could not be modulated by VIP and progesterone and displayed a reduced number of endometrial infiltrated CD4+LIF+ cells compared with fertile women.Conclusion The decrease of CD4+LIF+ cells in RSA patients could be related with the exacerbated inflammatory response observed in the maternal fetal dialogue model. © 2010 John Wiley & Sons A/S.

Registro:

Documento: Artículo
Título:Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens
Autor:Fraccaroli, L.; Grasso, E.; Zeitler, E.; Lombardi, E.; Gogorza, S.; Etchepareborda, J.J.; Nagle, C.; Cortelezzi, M.; Leirós, C.P.; Ramhorst, R.
Filiación:Immunopharmacology Laboratory, School of Sciences FCEyN, University of Buenos Aires, Buenos Aires, Argentina
Argentinean Society for Gynecology and Endocrinology Reproduction (SAEGRE), Buenos Aires, Argentina
Palabras clave:Chemokines; Recurrent spontaneous abortions; Tolerance and pregnancy; antigen; gelatinase B; leukemia inhibitory factor; progesterone; STAT3 protein; vasoactive intestinal polypeptide; article; CD4+ T lymphocyte; cell stimulation; controlled study; enzyme activity; female; female fertility; fetoplacental unit; human; human cell; inflammation; lymphocytic infiltration; nidation; peripheral blood mononuclear cell; priority journal; protein synthesis; recurrent abortion; spontaneous abortion; T lymphocyte; trophoblast; Abortion, Habitual; Antigens; CD4-Positive T-Lymphocytes; Cells, Cultured; Coculture Techniques; Embryo Implantation; Female; Humans; Immune Tolerance; Leukemia Inhibitory Factor; Leukocytes, Mononuclear; Male; Pregnancy; Progesterone; Trophoblasts; Vasoactive Intestinal Peptide
Año:2011
Volumen:65
Número:2
Página de inicio:133
Página de fin:145
DOI: http://dx.doi.org/10.1111/j.1600-0897.2010.00890.x
Título revista:American Journal of Reproductive Immunology
Título revista abreviado:Am. J. Reprod. Immunol.
ISSN:10467408
CODEN:AAJID
CAS:gelatinase B, 146480-36-6; progesterone, 57-83-0; vasoactive intestinal polypeptide, 37221-79-7; Antigens; LIF protein, human; Leukemia Inhibitory Factor; Progesterone, 57-83-0; Vasoactive Intestinal Peptide, 37221-79-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10467408_v65_n2_p133_Fraccaroli

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Citas:

---------- APA ----------
Fraccaroli, L., Grasso, E., Zeitler, E., Lombardi, E., Gogorza, S., Etchepareborda, J.J., Nagle, C.,..., Ramhorst, R. (2011) . Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens. American Journal of Reproductive Immunology, 65(2), 133-145.
http://dx.doi.org/10.1111/j.1600-0897.2010.00890.x
---------- CHICAGO ----------
Fraccaroli, L., Grasso, E., Zeitler, E., Lombardi, E., Gogorza, S., Etchepareborda, J.J., et al. "Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens" . American Journal of Reproductive Immunology 65, no. 2 (2011) : 133-145.
http://dx.doi.org/10.1111/j.1600-0897.2010.00890.x
---------- MLA ----------
Fraccaroli, L., Grasso, E., Zeitler, E., Lombardi, E., Gogorza, S., Etchepareborda, J.J., et al. "Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens" . American Journal of Reproductive Immunology, vol. 65, no. 2, 2011, pp. 133-145.
http://dx.doi.org/10.1111/j.1600-0897.2010.00890.x
---------- VANCOUVER ----------
Fraccaroli, L., Grasso, E., Zeitler, E., Lombardi, E., Gogorza, S., Etchepareborda, J.J., et al. Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens. Am. J. Reprod. Immunol. 2011;65(2):133-145.
http://dx.doi.org/10.1111/j.1600-0897.2010.00890.x