Storer, C.L.; Dickey, C.A.; Galigniana, M.D.; Rein, T.; Cox, M.B. "FKBP51 and FKBP52 in signaling and disease" (2011) Trends in Endocrinology and Metabolism. 22(12):481-490
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FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling, including receptor maturation, hormone binding and nuclear translocation. Although structurally similar, they are functionally divergent, which is largely attributed to differences in the FK1 domain and the proline-rich loop. FKBP51 and FKBP52 have emerged as likely contributors to a variety of hormone-dependent diseases, including stress-related diseases, immune function, reproductive functions and a variety of cancers. In addition, recent studies have implicated FKBP51 and FKBP52 in Alzheimer's disease and other protein aggregation disorders. This review summarizes our current understanding of FKBP51 and FKBP52 interactions within the receptor-chaperone complex, their contributions to health and disease, and their potential as therapeutic targets for the treatment of thesediseases. © 2011 Elsevier Ltd.


Documento: Artículo
Título:FKBP51 and FKBP52 in signaling and disease
Autor:Storer, C.L.; Dickey, C.A.; Galigniana, M.D.; Rein, T.; Cox, M.B.
Filiación:The Border Biomedical Research Center and Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, United States
Departments of Molecular Medicine and Psychiatry, University of South Florida Alzheimer's Institute, Tampa, FL 33613, United States
Instituto de Biología y Medicina Experimental (IBYME), CONICET (1428ADN) Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales (C1428EGA) Universidad de Buenos Aires, Buenos Aires, Argentina
Max Planck Institute of Psychiatry, 80804 Munich, Germany
Palabras clave:androgen receptor; antineoplastic agent; doxorubicin; estrogen receptor; immunoglobulin enhancer binding protein; mineralocorticoid receptor; multiprotein complex; progesterone receptor; protein FKBP51; protein FKBP52; protein kinase B; receptor chaperone complex; regulator protein; steroid hormone; steroid receptor; tacrolimus; unclassified drug; Alzheimer disease; anxiety disorder; bipolar disorder; breast carcinogenesis; breast tumor; cell proliferation; cellular distribution; complex formation; depression; disease association; drug targeting; genital system; human; immune system; immunopathology; mental stress; metabolic disorder; molecular pathology; neuropathology; nonhuman; pathophysiology; posttraumatic stress disorder; priority journal; prostate cancer; protein conformation; protein folding; protein function; protein localization; protein protein interaction; protein structure; review; schizophrenia; signal transduction; tauopathy; Alzheimer Disease; Animals; Humans; Molecular Chaperones; Molecular Targeted Therapy; Neoplasms; Protein Transport; Receptors, Steroid; Signal Transduction; Stress, Psychological; Tacrolimus Binding Proteins
Página de inicio:481
Página de fin:490
Título revista:Trends in Endocrinology and Metabolism
Título revista abreviado:Trends Endocrinol. Metab.
CAS:doxorubicin, 23214-92-8, 25316-40-9; protein kinase B, 148640-14-6; tacrolimus, 104987-11-3; Molecular Chaperones; Receptors, Steroid; Tacrolimus Binding Proteins, 5.2.1.-; tacrolimus binding protein 4, 5.2.1.-; tacrolimus binding protein 5,


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---------- APA ----------
Storer, C.L., Dickey, C.A., Galigniana, M.D., Rein, T. & Cox, M.B. (2011) . FKBP51 and FKBP52 in signaling and disease. Trends in Endocrinology and Metabolism, 22(12), 481-490.
---------- CHICAGO ----------
Storer, C.L., Dickey, C.A., Galigniana, M.D., Rein, T., Cox, M.B. "FKBP51 and FKBP52 in signaling and disease" . Trends in Endocrinology and Metabolism 22, no. 12 (2011) : 481-490.
---------- MLA ----------
Storer, C.L., Dickey, C.A., Galigniana, M.D., Rein, T., Cox, M.B. "FKBP51 and FKBP52 in signaling and disease" . Trends in Endocrinology and Metabolism, vol. 22, no. 12, 2011, pp. 481-490.
---------- VANCOUVER ----------
Storer, C.L., Dickey, C.A., Galigniana, M.D., Rein, T., Cox, M.B. FKBP51 and FKBP52 in signaling and disease. Trends Endocrinol. Metab. 2011;22(12):481-490.