Artículo

Azcoitia, I.; Arevalo, M.-A.; De Nicola, A.F.; Garcia-Segura, L.M. "Neuroprotective actions of estradiol revisited" (2011) Trends in Endocrinology and Metabolism. 22(12):467-473
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Abstract:

Results from animal experiments showing that estradiol is neuroprotective were challenged 10 years ago by findings indicating an increased risk of dementia and stroke in women over 65 years of age taking conjugated equine estrogens. Our understanding of the complex signaling of estradiol in neural cells has recently clarified the causes of this discrepancy. New data indicate that estradiol may lose its neuroprotective activity or even increase neural damage, a situation that depends on the duration of ovarian hormone deprivation and on age-associated modifications in the levels of other molecules that modulate estradiol action. These studies highlight the complex neuroprotective mechanisms of estradiol and suggest a window of opportunity during which effective hormonal therapy could promote brain function and cognition. © 2011 Elsevier Ltd.

Registro:

Documento: Artículo
Título:Neuroprotective actions of estradiol revisited
Autor:Azcoitia, I.; Arevalo, M.-A.; De Nicola, A.F.; Garcia-Segura, L.M.
Filiación:Cell Biology, Faculty of Biology, Complutense University of Madrid, E-28040 Madrid, Spain
Instituto Cajal, CSIC, Avenida Doctor Arce 37, E-28002 Madrid, Spain
Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental-CONICET, Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:aromatase inhibitor; conjugated estrogen; contraceptive agent; estradiol; estrogen; estrogen receptor alpha; estrogen receptor beta; gestagen; medroxyprogesterone acetate; neuroglobin; progesterone; seladin 1; selective estrogen receptor modulator; somatomedin C; somatomedin C receptor; unclassified drug; Wnt protein; Alzheimer disease; antiinflammatory activity; brain function; brain ischemia; brain mitochondrion; brain nerve cell; cancer risk; central nervous system; cognition; cytoplasm; dementia; demyelinating disease; endometrium cancer; estrogen activity; estrogen synthesis; high risk population; hormonal therapy; human; hypertension; mitochondrial genome; multiple sclerosis; nerve cell membrane; nervous system development; neuroprotection; nonhuman; Parkinson disease; postmenopause; priority journal; review; risk reduction; signal transduction; species difference; stroke; traumatic brain injury; Aging; Animals; Estradiol; Estrogen Replacement Therapy; Female; Humans; Male; Neuroglia; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes
Año:2011
Volumen:22
Número:12
Página de inicio:467
Página de fin:473
DOI: http://dx.doi.org/10.1016/j.tem.2011.08.002
Título revista:Trends in Endocrinology and Metabolism
Título revista abreviado:Trends Endocrinol. Metab.
ISSN:10432760
CODEN:TENME
CAS:estradiol, 50-28-2; medroxyprogesterone acetate, 71-58-9; progesterone, 57-83-0; somatomedin C, 67763-96-6; Estradiol, 50-28-2; Neuroprotective Agents
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10432760_v22_n12_p467_Azcoitia

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Citas:

---------- APA ----------
Azcoitia, I., Arevalo, M.-A., De Nicola, A.F. & Garcia-Segura, L.M. (2011) . Neuroprotective actions of estradiol revisited. Trends in Endocrinology and Metabolism, 22(12), 467-473.
http://dx.doi.org/10.1016/j.tem.2011.08.002
---------- CHICAGO ----------
Azcoitia, I., Arevalo, M.-A., De Nicola, A.F., Garcia-Segura, L.M. "Neuroprotective actions of estradiol revisited" . Trends in Endocrinology and Metabolism 22, no. 12 (2011) : 467-473.
http://dx.doi.org/10.1016/j.tem.2011.08.002
---------- MLA ----------
Azcoitia, I., Arevalo, M.-A., De Nicola, A.F., Garcia-Segura, L.M. "Neuroprotective actions of estradiol revisited" . Trends in Endocrinology and Metabolism, vol. 22, no. 12, 2011, pp. 467-473.
http://dx.doi.org/10.1016/j.tem.2011.08.002
---------- VANCOUVER ----------
Azcoitia, I., Arevalo, M.-A., De Nicola, A.F., Garcia-Segura, L.M. Neuroprotective actions of estradiol revisited. Trends Endocrinol. Metab. 2011;22(12):467-473.
http://dx.doi.org/10.1016/j.tem.2011.08.002