Artículo
Vilas, G.L.; Aldonatti, C.; San Martín De Viale, L.C.; Del Ríos De Molina, M.C. "Effect of α lipoic acid amide on hexachlorobenzene porphyria" (1999) Biochemistry and Molecular Biology International. 47(5):815-823
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Abstract:
The aim of this work is to study the effect of thioctamide - the commercial form of a lipoic acid amide - on the porphyrinogenic action of hexachlorobenzene (HCB). For this purpose, porphyria was induced in rats by chronic HCB treatment, with or without simultaneous thioctamide administration. Two different groups of rats were used as reference: one treated with vehicle (control) and the other treated with thioctamide (TO). Urine δ aminolevulic acid, porphobilinogen, and porphyrin excretions were lower in the HCB + TO treated group than in the HCB group, and the same happened with liver uroporphyrin accumulation. On the other hand, the second stage of uroporphyrinogen-decarboxylase activity was significantly higher in the HCB + TO group than in the HCB group. δ aminolevulic acid synthase activity was higher in the HCB group. Hepatic thiobarbituric acid reactive substances were lower in HCB + TO group than in HCB group. Thus, we might suggest that TO would decrease HCB effects by means of its free radical scavenging ability, and by having a direct effect on uroporphyrinogen-decarboxylase activity.
Registro:
| Documento: | Artículo |
| Título: | Effect of α lipoic acid amide on hexachlorobenzene porphyria |
| Autor: | Vilas, G.L.; Aldonatti, C.; San Martín De Viale, L.C.; Del Ríos De Molina, M.C. |
| Filiación: | Dpto. de Quimica Biologica, Fac. de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Capital Federal (1428), Argentina |
| Palabras clave: | α lipoic acid; Free radical scavenger; Hexachlorobenzene; Lipid peroxidation; Porphyria; Thioctamide; Uroporphyrinogen decarboxylase; 5 aminolevulinate synthase; amide; aminolevulinic acid; hexachlorobenzene; porphobilinogen; porphyrin; scavenger; thiobarbituric acid reactive substance; thioctic acid; uroporphyrin; uroporphyrinogen decarboxylase; animal experiment; animal model; article; bioaccumulation; controlled study; enzyme activity; excretion; female; liver; nonhuman; porphyria; rat; urine level; Animals; Female; Free Radical Scavengers; Hexachlorobenzene; Porphyrias; Rats; Rats, Wistar; Thioctic Acid; Time Factors; Animalia |
| Año: | 1999 |
| Volumen: | 47 |
| Número: | 5 |
| Página de inicio: | 815 |
| Página de fin: | 823 |
| Título revista: | Biochemistry and Molecular Biology International |
| Título revista abreviado: | Biochem. Mol. Biol. Int. |
| ISSN: | 10399712 |
| CODEN: | BMBIE |
| CAS: | Free Radical Scavengers; Hexachlorobenzene, 118-74-1; Thioctic Acid, 62-46-4 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10399712_v47_n5_p815_Vilas |
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Citas:
---------- APA ----------
Vilas, G.L., Aldonatti, C., San Martín De Viale, L.C. & Del Ríos De Molina, M.C. (1999) . Effect of α lipoic acid amide on hexachlorobenzene porphyria. Biochemistry and Molecular Biology International, 47(5), 815-823.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10399712_v47_n5_p815_Vilas [ ]
---------- CHICAGO ----------
Vilas, G.L., Aldonatti, C., San Martín De Viale, L.C., Del Ríos De Molina, M.C. "Effect of α lipoic acid amide on hexachlorobenzene porphyria" . Biochemistry and Molecular Biology International 47, no. 5 (1999) : 815-823.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10399712_v47_n5_p815_Vilas [ ]
---------- MLA ----------
Vilas, G.L., Aldonatti, C., San Martín De Viale, L.C., Del Ríos De Molina, M.C. "Effect of α lipoic acid amide on hexachlorobenzene porphyria" . Biochemistry and Molecular Biology International, vol. 47, no. 5, 1999, pp. 815-823.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10399712_v47_n5_p815_Vilas [ ]
---------- VANCOUVER ----------
Vilas, G.L., Aldonatti, C., San Martín De Viale, L.C., Del Ríos De Molina, M.C. Effect of α lipoic acid amide on hexachlorobenzene porphyria. Biochem. Mol. Biol. Int. 1999;47(5):815-823.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10399712_v47_n5_p815_Vilas [ ]
