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Muñiz, J.A.; Gomez, G.; González, B.; Rivero-Echeto, M.C.; Cadet, J.L.; García-Rill, E.; Urbano, F.J.; Bisagno, V. "Combined Effects of Simultaneous Exposure to Caffeine and Cocaine in the Mouse Striatum" (2016) Neurotoxicity Research. 29(4):525-538
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Abstract:

Caffeine is the world’s most popular psychoactive drug and is also an active adulterant found in many drugs of abuse, including seized cocaine samples. Despite several studies which examine the effects of caffeine or cocaine administered as single agents, little data are available for these agents when given in combination. The purpose of the present study was to determine if combined intake of both psychostimulants can lead to maladaptive changes in striatal function. Mice were injected with a binge regimen (intermittent treatment for 13 days) of caffeine (3 × 5 mg/kg), cocaine (3 × 10 mg/kg), or combined administration. We found that chronic caffeine potentiated locomotion induced by cocaine and that both caffeine-treated groups showed sensitization. Striatal tissue was obtained 24 h and 7 days after last injection (withdrawal) for immunohistochemistry and mRNA expression. Our results show that combined intake of both psychostimulants can increase GFAP immunoreactivity in the striatum at both times post treatment. Gene expression analysis, targeted at dopamine, adenosine, and glutamate receptor subunit genes, revealed significant transcript down-regulation in the dorsal striatum of AMPA, NMDA, D1 and D2 receptor subunit mRNA expression in the group that received combined treatment, but not after individual administration. At withdrawal, we found increased D1 receptor mRNA expression along with increased A1, AMPA, NMDA, and metabotropic subunit expression. A2A mRNA showed decreased expression after both times in all experimental groups. Our study provides evidence that there are striatal alterations mediated by combined caffeine and cocaine administration, and highlights negative outcomes of chronic intake of both psychostimulants. © 2016, Springer Science+Business Media New York.

Registro:

Documento: Artículo
Título:Combined Effects of Simultaneous Exposure to Caffeine and Cocaine in the Mouse Striatum
Autor:Muñiz, J.A.; Gomez, G.; González, B.; Rivero-Echeto, M.C.; Cadet, J.L.; García-Rill, E.; Urbano, F.J.; Bisagno, V.
Filiación:Instituto de Investigaciones Farmacológicas (Universidad de Buenos Aires—Consejo Nacional de Investigaciones Científicas y Técnicas), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Laboratorio de Fisiología y Biología Molecular, Instituto de Fisiología, Biología Molecular y Neurociencias, Departamento de Fisiología, Biología Molecular y Celular “Dr. Hector Maldonado” (DFBMC), Universidad de Buenos Aires—Consejo Nacional de Investigaciones Científicas y Técnicas, Junín 956, piso 5, Ciudad Autónoma de Buenos Aires, Buenos Aires, C1113, Argentina
Molecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, Baltimore, MD, United States
Department of Neurobiology and Developmental Sciences, Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, United States
Palabras clave:Astroglia; Caffeine; Cocaine; Dopamine; Locomotor sensitization; Striatum; adenosine A2a receptor; alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid; caffeine; cocaine; dopamine 1 receptor; dopamine 2 receptor; glial fibrillary acidic protein; glutamate receptor; messenger RNA; n methyl dextro aspartic acid; caffeine; central stimulant agent; cocaine; dopamine uptake inhibitor; drug combination; glial fibrillary acidic protein; membrane protein; messenger RNA; nerve protein; animal experiment; animal tissue; Article; astrocytosis; brain function; controlled study; corpus striatum; down regulation; gene expression; genetic analysis; immunohistochemistry; immunoreactivity; locomotion; maladjustment; male; mouse; nerve cell plasticity; nonhuman; priority journal; sensitization; upregulation; analysis of variance; animal; C57BL mouse; corpus striatum; drug combination; drug effects; gene expression regulation; genetics; metabolism; time factor; Analysis of Variance; Animals; Caffeine; Central Nervous System Stimulants; Cocaine; Corpus Striatum; Dopamine Uptake Inhibitors; Drug Combinations; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Locomotion; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; RNA, Messenger; Time Factors
Año:2016
Volumen:29
Número:4
Página de inicio:525
Página de fin:538
DOI: http://dx.doi.org/10.1007/s12640-016-9601-0
Título revista:Neurotoxicity Research
Título revista abreviado:Neurotoxic. Res.
ISSN:10298428
CODEN:NURRF
CAS:alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid, 77521-29-0; caffeine, 58-08-2; cocaine, 50-36-2, 53-21-4, 5937-29-1; n methyl dextro aspartic acid, 6384-92-5; Caffeine; Central Nervous System Stimulants; Cocaine; Dopamine Uptake Inhibitors; Drug Combinations; Glial Fibrillary Acidic Protein; Membrane Proteins; Nerve Tissue Proteins; RNA, Messenger
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10298428_v29_n4_p525_Muniz

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Citas:

---------- APA ----------
Muñiz, J.A., Gomez, G., González, B., Rivero-Echeto, M.C., Cadet, J.L., García-Rill, E., Urbano, F.J.,..., Bisagno, V. (2016) . Combined Effects of Simultaneous Exposure to Caffeine and Cocaine in the Mouse Striatum. Neurotoxicity Research, 29(4), 525-538.
http://dx.doi.org/10.1007/s12640-016-9601-0
---------- CHICAGO ----------
Muñiz, J.A., Gomez, G., González, B., Rivero-Echeto, M.C., Cadet, J.L., García-Rill, E., et al. "Combined Effects of Simultaneous Exposure to Caffeine and Cocaine in the Mouse Striatum" . Neurotoxicity Research 29, no. 4 (2016) : 525-538.
http://dx.doi.org/10.1007/s12640-016-9601-0
---------- MLA ----------
Muñiz, J.A., Gomez, G., González, B., Rivero-Echeto, M.C., Cadet, J.L., García-Rill, E., et al. "Combined Effects of Simultaneous Exposure to Caffeine and Cocaine in the Mouse Striatum" . Neurotoxicity Research, vol. 29, no. 4, 2016, pp. 525-538.
http://dx.doi.org/10.1007/s12640-016-9601-0
---------- VANCOUVER ----------
Muñiz, J.A., Gomez, G., González, B., Rivero-Echeto, M.C., Cadet, J.L., García-Rill, E., et al. Combined Effects of Simultaneous Exposure to Caffeine and Cocaine in the Mouse Striatum. Neurotoxic. Res. 2016;29(4):525-538.
http://dx.doi.org/10.1007/s12640-016-9601-0