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Raineri, M.; González, B.; Rivero-Echeto, C.; Muñiz, J.A.; Gutiérrez, M.L.; Ghanem, C.I.; Cadet, J.L.; García-Rill, E.; Urbano, F.J.; Bisagno, V. "Differential Effects of Environment-Induced Changes in Body Temperature on Modafinil’s Actions Against Methamphetamine-Induced Striatal Toxicity in Mice" (2015) Neurotoxicity Research. 27(1):71-83
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Abstract:

Methamphetamine (METH) exposure can produce hyperthermia that might lead to toxicity and death. Modafinil is a wake-promoting compound that is also been prescribed off-label to treat METH dependence. Modafinil has shown neuroprotective properties against METH harmful effects in animal models. The goal of the present study was to test if the prevention of hyperthermia might play a role on the neuroprotective actions of modafinil against METH toxicity using various ambient temperatures. METH was administered to female C57BL/6 mice in a binge regimen: 4 × 5 mg/kg, 2 h apart; modafinil (90 mg/kg) was injected twice, 1 h before first and fourth METH injections. Drugs were given at cold ambient temperature (14 °C) or hot ambient temperature (29 °C). Body temperature was measured during treatments. Brains were dissected out 6 days after treatments and processed for tyrosine hydroxylase (TH), dopamine transporter (DAT), GFAP and c-Fos immunohistochemistry. Exposure to hot ambient temperature exacerbated METH toxicity evidenced by striatal reductions in TH and DAT and increased GFAP immmunoreactivity. Modafinil counteracted reductions in TH and DAT, but failed to block astroglial activation. At both ambient temperatures tested modafinil did induce increments in GFAP, but the magnitude was significantly lower than the one induced by METH. Both drugs induced increases in c-Fos positive nuclei; modafinil did not block this effect. Our results suggest that protective effects of modafinil against METH-induced neurotoxicity may be dependent, in part, to its hypothermic effects. Nevertheless, modafinil maintained some protective properties on METH-induced alterations in the striatum at different ambient temperatures. © 2014, Springer Science+Business Media New York.

Registro:

Documento: Artículo
Título:Differential Effects of Environment-Induced Changes in Body Temperature on Modafinil’s Actions Against Methamphetamine-Induced Striatal Toxicity in Mice
Autor:Raineri, M.; González, B.; Rivero-Echeto, C.; Muñiz, J.A.; Gutiérrez, M.L.; Ghanem, C.I.; Cadet, J.L.; García-Rill, E.; Urbano, F.J.; Bisagno, V.
Filiación:Instituto de Investigaciones Farmacológicas, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (ININFA-UBA-CONICET), Ciudad Autónoma de Buenos Aires, Junín 956, piso 5, Buenos Aires, C1113, Argentina
Laboratorio de Fisiología y Biología Molecular, Instituto de Fisiología, Biología Molecular y Neurociencias, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Molecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, Baltimore, MD, United States
Center for Translational Neuroscience, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, United States
Palabras clave:Astroglia; Dopamine; Methamphetamine; Modafinil; Striatum; Toxicity; dopamine transporter; glial fibrillary acidic protein; methamphetamine; modafinil; placebo; protein c fos; tyrosine 3 monooxygenase; benzhydryl derivative; dopamine receptor stimulating agent; methamphetamine; modafinil; neuroprotective agent; animal cell; animal experiment; animal model; animal tissue; Article; body temperature disorder; body temperature measurement; cell nucleus; cellular distribution; controlled study; corpus striatum; correlational study; disease marker; down regulation; drug protein binding; drug targeting; environmental exposure; environmental temperature; female; hyperthermia; immunohistochemistry; immunoreactivity; mouse; mouse model; neuropharmacology; neuroprotection; neurotoxicity; nonhuman; priority journal; protein determination; protein expression; protein localization; thermal exposure; thermoregulation; tissue distribution; upregulation; animal; C57BL mouse; chemically induced; cold; cytology; drug effects; heat; hypothermia; metabolism; neostriatum; nerve cell; Animals; Benzhydryl Compounds; Cold Temperature; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Female; Hot Temperature; Hypothermia; Methamphetamine; Mice; Mice, Inbred C57BL; Neostriatum; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Tyrosine 3-Monooxygenase
Año:2015
Volumen:27
Número:1
Página de inicio:71
Página de fin:83
DOI: http://dx.doi.org/10.1007/s12640-014-9493-9
Título revista:Neurotoxicity Research
Título revista abreviado:Neurotoxic. Res.
ISSN:10298428
CODEN:NURRF
CAS:methamphetamine, 28297-73-6, 51-57-0, 537-46-2, 7632-10-2; modafinil, 68693-11-8; tyrosine 3 monooxygenase, 9036-22-0; Benzhydryl Compounds; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Methamphetamine; modafinil; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Tyrosine 3-Monooxygenase
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10298428_v27_n1_p71_Raineri

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Citas:

---------- APA ----------
Raineri, M., González, B., Rivero-Echeto, C., Muñiz, J.A., Gutiérrez, M.L., Ghanem, C.I., Cadet, J.L.,..., Bisagno, V. (2015) . Differential Effects of Environment-Induced Changes in Body Temperature on Modafinil’s Actions Against Methamphetamine-Induced Striatal Toxicity in Mice. Neurotoxicity Research, 27(1), 71-83.
http://dx.doi.org/10.1007/s12640-014-9493-9
---------- CHICAGO ----------
Raineri, M., González, B., Rivero-Echeto, C., Muñiz, J.A., Gutiérrez, M.L., Ghanem, C.I., et al. "Differential Effects of Environment-Induced Changes in Body Temperature on Modafinil’s Actions Against Methamphetamine-Induced Striatal Toxicity in Mice" . Neurotoxicity Research 27, no. 1 (2015) : 71-83.
http://dx.doi.org/10.1007/s12640-014-9493-9
---------- MLA ----------
Raineri, M., González, B., Rivero-Echeto, C., Muñiz, J.A., Gutiérrez, M.L., Ghanem, C.I., et al. "Differential Effects of Environment-Induced Changes in Body Temperature on Modafinil’s Actions Against Methamphetamine-Induced Striatal Toxicity in Mice" . Neurotoxicity Research, vol. 27, no. 1, 2015, pp. 71-83.
http://dx.doi.org/10.1007/s12640-014-9493-9
---------- VANCOUVER ----------
Raineri, M., González, B., Rivero-Echeto, C., Muñiz, J.A., Gutiérrez, M.L., Ghanem, C.I., et al. Differential Effects of Environment-Induced Changes in Body Temperature on Modafinil’s Actions Against Methamphetamine-Induced Striatal Toxicity in Mice. Neurotoxic. Res. 2015;27(1):71-83.
http://dx.doi.org/10.1007/s12640-014-9493-9