Abstract:
The effect of anaesthesia with Enflurane or Isoflurane (a single dose of 1 ml/kg, i.p.) administered to animals treated 24 hours before with cobaltous chloride (a single dose of 125 μmol/kg, i.p.), a known inductor of Heme-ox, was investigated. The expected induction of Heme-ox (285%) produced by Co administration was abolished by anaesthesia. A 45% reduction of blood Porphobilinogenase and Deaminase activities was found after treatment with Co and Isoflurane, reproducing in these animals the biochemical signs of acute porphyria. The regulation of heme pathway and the involvement of the metabolizing drug enzyme system was also studied.
Registro:
Documento: |
Artículo
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Título: | Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase |
Autor: | Buzaleh, A.M.; Del Carmen Batlle, A.M. |
Filiación: | CIPYP, Facul. de Cien. Exactas y Naturales, University of Buenos Aires, Viamonte 1881 10 'A', C1056AB - Buenos Aires, Argentina
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Palabras clave: | Cobalt; Drug metabolizing enzyme system; Enflurane; Heme metabolism; Heme oxygenase; Isoflurane; cobalt chloride; enflurane; enzyme inducing agent; heme; heme oxygenase; inhalation anesthetic agent; isoflurane; porphobilinogen deaminase; acute intermittent porphyria; anesthesia; animal experiment; animal model; article; biochemistry; controlled study; drug mechanism; drug metabolism; enzyme activity; enzyme blood level; enzyme induction; male; mouse; nonhuman; priority journal; regulatory mechanism |
Año: | 2000
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Volumen: | 11
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Número: | 1
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Página de inicio: | 39
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Página de fin: | 47
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Título revista: | Pharmacology Reviews and Communications
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Título revista abreviado: | Pharmacol. Rev. Commun.
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ISSN: | 10288945
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CODEN: | PHRCF
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CAS: | cobalt chloride, 1332-82-7, 7646-79-9; enflurane, 13838-16-9; heme oxygenase, 9059-22-7; heme, 14875-96-8; isoflurane, 26675-46-7; porphobilinogen deaminase, 9036-47-9, 9074-91-3
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10288945_v11_n1_p39_Buzaleh |
Referencias:
- Batlle, A.M., Wider de Xifra, E.A., Stella, A.M., A simple method for measuring erythrocyte porphobilinogenase and its use in the diagnosis of acute intermittent porphyria (1978) International Journal of Biochemistry, 9, pp. 871-875
- Buzaleh, A.M., Vazquez, E., Batlle A.M. del, C., Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption (1995) General Pharmacology, 26, pp. 1425-1429
- Buzaleh, A.M., Vasquez, E., Batlle A.M. del, C., The involvement of microsomal drug metabolizing system during Isoflurane anaesthesia in alcoholized animals (1996) Pharmacology Communications, 7, pp. 101-106
- Buzaleh, A.M., Vazquez, E., Enríquez de Salamanca, R., Batlle A.M. del, C., An overview of anaesthesia and porphyria (1997) Endocrinology and Metabolism, 4, pp. 267-279. , (Review)
- Daido, A., Aniya, Y., Alteration of liver glutathione S-transferase and protease activities by cobalt chloride treatment of rats (1994) Japanese Journal of Pharmacology, 66, pp. 357-362
- De Matteis, F., Gibbs, A.H., The effect of cobaltous chloride on liver haem metabolism in the rat. Evidence for inhibition of haem synthesis and for increased haem degradation (1976) Annual Clinical Research, 8 (SUPPL. 17), pp. 193-197
- El-Mouelhi, M., Didolkar, M.S., Elias, E.G., Guengerich, F.P., Kauffman, F.C., Hepatic drug-metabolizing enzymes in primary and secondary tumors of human liver (1987) Cancer Research, 47, pp. 460-466
- Habig, W.H., Pabst, M.J., Jakoby, W.B., Glutathion S-transferases (1974) Journal of Biological Chemistry, 249, pp. 7130-7139
- Halsey, M.J., Drug interactions in anaesthesia (1987) British Journal of Anaesthesia, 59, pp. 112-123
- Kaliman, P.A., Barannik, T.V., Regulation of δ-Aminolevulinate synthase activity during the development of oxidative stress (1999) Biochemistry, 64, pp. 699-704. , (Moscow)
- Keyne, S.M., Tyrell, R.M., Heme oxygenase is the major 32-kDA stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite (1989) Proceedings of the National Academy of Sciences of the United States of America, 86, pp. 99-103
- Kharasch, E.D., Thummel, K.E., Identification of cytochrome P4502E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane (1993) Anesthesiology, 79, pp. 795-807
- Kharasch, E.D., Thummel, K.E., Mautz, D., Bosse, S., Clinical enflurane metabolism by cytochrome P450 2E1 (1994) Clinical Pharmacology Therapy, 55, pp. 434-440
- Knox, W.E., L-Tryptophan 2,3-Dioxygenase (Tryptophan Pyrrolase) (Rat Liver) (1970) Methods in Enzymology, 17, pp. 415-417
- Lanks, K.W., Modulators of the eukaryotic heat shock response (1986) Experimental Cellular Research, 165, pp. 1-10
- Lowry, O., Rosebrough, N., Farr, A., Randall, R., Protein measurement with the Folin phenol reagent (1951) Journal of Biological Chemistry, 193, pp. 265-275
- Llesuy, S.F., Tomaro, M.L., Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage (1994) Biochimica et. Biophysica Acta, 1223, pp. 9-14
- Maines, M.D., Kappas, A., Cobalt stimulation of heme degradation in the liver. Dissociation of microsomal oxidation of heme from cytochrome P-450 (1975) Journal of Biological Chemistry, 250, pp. 4171-4177
- Maines, M.D., Kappas, A., The induction of heme oxidation in various tissues by trace metals: Evidence for the catabolism of endogenous heme by hepatic heme oxygenase (1976) Annual Clinical Research, 8, pp. 39-46
- Maines, M.D., Kappas, A., Metals as regulators of heme metabolism (1977) Science, 198, pp. 1215-1221
- Marver, H., Tschudy, D., Perlroth, M., Collins, A., δ-Aminolevulinic acid synthetase I. Studies in liver homogenates (1966) Journal of Biological Chemistry, 241, pp. 2803-2809
- Omura, T., Sato, R., The carbon monoxide-binding pigment of liver microsomes (1964) Journal of Biological Chemistry, 239, pp. 2370-2378
- Reinke, L.A., Moyer, M.J., A microsomal oxidation which is highly inducible by ethanol (1985) Drug Metabolism and Disposition, 13, pp. 548-552
- Tenhunen, R., Marver, H.S., Schmid, R., The enzymatic catabolism of hemoglobin: Stimulation of microsomal heme oxygenase by hemin (1970) Journal of Laboratory Clinical Medicine, 75, pp. 410-421
- Tom, D.J., Rodgers, P.A., Shokoohi, V., Stevenson, D.K., Dennery, P.A., Hepatic heme oxygenase is inducible in neonatal rats during the early postnatal period (1996) Pediatric Research, 40, pp. 288-293
Citas:
---------- APA ----------
Buzaleh, A.M. & Del Carmen Batlle, A.M.
(2000)
. Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase. Pharmacology Reviews and Communications, 11(1), 39-47.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10288945_v11_n1_p39_Buzaleh [ ]
---------- CHICAGO ----------
Buzaleh, A.M., Del Carmen Batlle, A.M.
"Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase"
. Pharmacology Reviews and Communications 11, no. 1
(2000) : 39-47.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10288945_v11_n1_p39_Buzaleh [ ]
---------- MLA ----------
Buzaleh, A.M., Del Carmen Batlle, A.M.
"Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase"
. Pharmacology Reviews and Communications, vol. 11, no. 1, 2000, pp. 39-47.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10288945_v11_n1_p39_Buzaleh [ ]
---------- VANCOUVER ----------
Buzaleh, A.M., Del Carmen Batlle, A.M. Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase. Pharmacol. Rev. Commun. 2000;11(1):39-47.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10288945_v11_n1_p39_Buzaleh [ ]