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Abstract:

The effect of anaesthesia with Enflurane or Isoflurane (a single dose of 1 ml/kg, i.p.) administered to animals treated 24 hours before with cobaltous chloride (a single dose of 125 μmol/kg, i.p.), a known inductor of Heme-ox, was investigated. The expected induction of Heme-ox (285%) produced by Co administration was abolished by anaesthesia. A 45% reduction of blood Porphobilinogenase and Deaminase activities was found after treatment with Co and Isoflurane, reproducing in these animals the biochemical signs of acute porphyria. The regulation of heme pathway and the involvement of the metabolizing drug enzyme system was also studied.

Registro:

Documento: Artículo
Título:Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase
Autor:Buzaleh, A.M.; Del Carmen Batlle, A.M.
Filiación:CIPYP, Facul. de Cien. Exactas y Naturales, University of Buenos Aires, Viamonte 1881 10 'A', C1056AB - Buenos Aires, Argentina
Palabras clave:Cobalt; Drug metabolizing enzyme system; Enflurane; Heme metabolism; Heme oxygenase; Isoflurane; cobalt chloride; enflurane; enzyme inducing agent; heme; heme oxygenase; inhalation anesthetic agent; isoflurane; porphobilinogen deaminase; acute intermittent porphyria; anesthesia; animal experiment; animal model; article; biochemistry; controlled study; drug mechanism; drug metabolism; enzyme activity; enzyme blood level; enzyme induction; male; mouse; nonhuman; priority journal; regulatory mechanism
Año:2000
Volumen:11
Número:1
Página de inicio:39
Página de fin:47
Título revista:Pharmacology Reviews and Communications
Título revista abreviado:Pharmacol. Rev. Commun.
ISSN:10288945
CODEN:PHRCF
CAS:cobalt chloride, 1332-82-7, 7646-79-9; enflurane, 13838-16-9; heme oxygenase, 9059-22-7; heme, 14875-96-8; isoflurane, 26675-46-7; porphobilinogen deaminase, 9036-47-9, 9074-91-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10288945_v11_n1_p39_Buzaleh

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Citas:

---------- APA ----------
Buzaleh, A.M. & Del Carmen Batlle, A.M. (2000) . Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase. Pharmacology Reviews and Communications, 11(1), 39-47.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10288945_v11_n1_p39_Buzaleh [ ]
---------- CHICAGO ----------
Buzaleh, A.M., Del Carmen Batlle, A.M. "Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase" . Pharmacology Reviews and Communications 11, no. 1 (2000) : 39-47.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10288945_v11_n1_p39_Buzaleh [ ]
---------- MLA ----------
Buzaleh, A.M., Del Carmen Batlle, A.M. "Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase" . Pharmacology Reviews and Communications, vol. 11, no. 1, 2000, pp. 39-47.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10288945_v11_n1_p39_Buzaleh [ ]
---------- VANCOUVER ----------
Buzaleh, A.M., Del Carmen Batlle, A.M. Administration of volatile anaesthetics to animals treated with cobalt as inductor of heme oxygenase. Pharmacol. Rev. Commun. 2000;11(1):39-47.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10288945_v11_n1_p39_Buzaleh [ ]