Artículo

Monsalve, L.N.; Cerrutti, P.; Galvagno, M.A.; Baldessari, A. "Rhodotorula minuta-mediated bioreduction of 1,2-diketones" (2010) Biocatalysis and Biotransformation. 28(2):137-143
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Abstract:

The reduction of cyclic and acyclic 1,2-diketones was investigated by employing whole cells of the yeast Rhodotorula minuta as biocatalyst. The reactions showed a variable degree of regio- and enantioselectivity depending on the nature of the substrate. In the case of cyclic diketones, the reduction afforded a mixture of diastereomeric diols only. The reduction of acyclic diketones allowed production of both the hydroxy ketone and the diol, in a two-step reaction. The first step was highly regio- and stereoselective, affording the hydroxy ketone of (S)-configuration with high enantiomeric excess. After longer reaction times the corresponding (S,S)-diols were obtained in high yield and diastereomeric excess. © 2010 Informa UK Ltd.

Registro:

Documento: Artículo
Título:Rhodotorula minuta-mediated bioreduction of 1,2-diketones
Autor:Monsalve, L.N.; Cerrutti, P.; Galvagno, M.A.; Baldessari, A.
Filiación:Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina
Departamento de Ingeniería Química, Facultad de Ingeniería, Universidad de Buenos Aires, Buenos Aires, Argentina
IIB-Intech-CONICET-UNSAM, Buenos Aires, Argentina
Palabras clave:1,2-Diketones; Bioreduction; Rhodotorula minuta; Bioreductions; Diastereomeric; Diastereomeric excess; Diketones; Enantiomeric excess; High yield; Reaction time; Stereo-selective; Two-step reactions; Whole cell; Enantioselectivity; Ketones; 1,2 cyclohexanediol derivative; 1,2 diketone derivative; 2 phenyl 2,3 propanedione; 2,3 butanedione; 2,3 pentanedione; diketone; unclassified drug; article; controlled study; enantiomer; enantioselectivity; gas liquid chromatography; nonhuman; reduction; Rhodotorula; Rhodotorula minuta; stereochemistry; Rhodotorula minuta
Año:2010
Volumen:28
Número:2
Página de inicio:137
Página de fin:143
DOI: http://dx.doi.org/10.3109/10242420903515445
Título revista:Biocatalysis and Biotransformation
Título revista abreviado:Biocatal. Biotransform.
ISSN:10242422
CODEN:BOBOE
CAS:2,3 butanedione, 431-03-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10242422_v28_n2_p137_Monsalve

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Citas:

---------- APA ----------
Monsalve, L.N., Cerrutti, P., Galvagno, M.A. & Baldessari, A. (2010) . Rhodotorula minuta-mediated bioreduction of 1,2-diketones. Biocatalysis and Biotransformation, 28(2), 137-143.
http://dx.doi.org/10.3109/10242420903515445
---------- CHICAGO ----------
Monsalve, L.N., Cerrutti, P., Galvagno, M.A., Baldessari, A. "Rhodotorula minuta-mediated bioreduction of 1,2-diketones" . Biocatalysis and Biotransformation 28, no. 2 (2010) : 137-143.
http://dx.doi.org/10.3109/10242420903515445
---------- MLA ----------
Monsalve, L.N., Cerrutti, P., Galvagno, M.A., Baldessari, A. "Rhodotorula minuta-mediated bioreduction of 1,2-diketones" . Biocatalysis and Biotransformation, vol. 28, no. 2, 2010, pp. 137-143.
http://dx.doi.org/10.3109/10242420903515445
---------- VANCOUVER ----------
Monsalve, L.N., Cerrutti, P., Galvagno, M.A., Baldessari, A. Rhodotorula minuta-mediated bioreduction of 1,2-diketones. Biocatal. Biotransform. 2010;28(2):137-143.
http://dx.doi.org/10.3109/10242420903515445