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Abstract:

Neuroimmune-endocrine interactions seem to be central to the dialogue between the mother and the growing embryo during normal pregnancy. A proinflammatory Th1 microenvironment appears to be associated with embryo implantation but an excess of these cytokines may be deleterious. When normal gestation is subjected to stressful stimuli as those provided by a chronic inflammatory milieu, the activation profile of T cells and macrophages may be temporarily changed. Although much evidence supports the protective role of pregnancy in Th1 autoimmune diseases, the comprehension of the maternofetal interaction in an inflammatory context may serve to get more insight into pregnancy failures. Macrophages integrate multiple inputs and signals of neuroimmune-endocrine systems and they appear as major participants in either embryo implantation or loss. Changes at the macrophage level during gestation might help to understand their regulatory role in embryo implantation as well as to disclose their local and systemic pathogenic potential. Copyright © 2008 S. Karger AG.

Registro:

Documento: Artículo
Título:Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: Focus on macrophage activation
Autor:Larocca, L.; Ramhorst, R.; Roca, V.; Calafat, M.; Aisemberg, J.; Franchi, A.; Pérez Leirós, C.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina
Centro de Estudios Farmacológicos Y Botánicos (CEFYBO), Facultad de Medicina, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina
Ciudad Universitaria, Pab. II, 1428 Buenos Aires, Argentina
Palabras clave:Autoimmune diseases, chronic; Macrophages; Neuroimmune regulation; Pregnancy; catecholamine; estrogen; estrogen receptor beta; glucocorticoid receptor; hydrocortisone; interleukin 1; interleukin 10; interleukin 12; interleukin 6; leukemia inhibitory factor receptor; lipopolysaccharide; progesterone; prolactin receptor; tumor necrosis factor alpha; adaptive immunity; autoimmune disease; cell activation; cellular immunity; disease course; embryo development; endocrine function; first trimester pregnancy; gestation period; hormonal regulation; human; immunoregulation; innate immunity; macrophage activation; maternal stress; mother fetus relationship; nidation; nonhuman; priority journal; review; Th1 cell; Th2 cell; Animals; Autoimmune Diseases; Embryo Implantation; Female; Humans; Immune Tolerance; Inflammation; Macrophage Activation; Macrophages; Maternal-Fetal Exchange; Neuroimmunomodulation; Neurosecretory Systems; Pregnancy; Pregnancy Complications; Th1 Cells
Año:2008
Volumen:15
Número:1
Página de inicio:84
Página de fin:90
DOI: http://dx.doi.org/10.1159/000135628
Título revista:NeuroImmunoModulation
Título revista abreviado:NeuroImmunomodulation
ISSN:10217401
CODEN:NROIE
CAS:hydrocortisone, 50-23-7; interleukin 12, 138415-13-1; progesterone, 57-83-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10217401_v15_n1_p84_Larocca

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Citas:

---------- APA ----------
Larocca, L., Ramhorst, R., Roca, V., Calafat, M., Aisemberg, J., Franchi, A. & Pérez Leirós, C. (2008) . Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: Focus on macrophage activation. NeuroImmunoModulation, 15(1), 84-90.
http://dx.doi.org/10.1159/000135628
---------- CHICAGO ----------
Larocca, L., Ramhorst, R., Roca, V., Calafat, M., Aisemberg, J., Franchi, A., et al. "Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: Focus on macrophage activation" . NeuroImmunoModulation 15, no. 1 (2008) : 84-90.
http://dx.doi.org/10.1159/000135628
---------- MLA ----------
Larocca, L., Ramhorst, R., Roca, V., Calafat, M., Aisemberg, J., Franchi, A., et al. "Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: Focus on macrophage activation" . NeuroImmunoModulation, vol. 15, no. 1, 2008, pp. 84-90.
http://dx.doi.org/10.1159/000135628
---------- VANCOUVER ----------
Larocca, L., Ramhorst, R., Roca, V., Calafat, M., Aisemberg, J., Franchi, A., et al. Neuroimmune-endocrine interactions during early pregnancy in an autoimmune context: Focus on macrophage activation. NeuroImmunomodulation. 2008;15(1):84-90.
http://dx.doi.org/10.1159/000135628