Navegar

Colección

Datos Estadísticas

Artículo

Urtreger, A.J.; Werbajh, S.E.; Verrecchia, F.; Mauviel, A.; Puricelli, L.I.; Kornblihtt, A.R.; Bal De Kier Joffé, E.D. "Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential" (2006) Oncology Reports. 16(6):1403-1410
Estamos trabajando para incorporar este artículo al repositorio
Consulte la política de Acceso Abierto del editor

Abstract:

In the present work we used a murine mammary cancer model of two related adenocarcinomas with different lung metastasizing abilities, to compare their global gene expression profiles. Clontech Atlas mouse cDNA microarrays of primary cultured tumor cells were employed to identify genes that are modulated in the more metastatic variant MM3 relative to its parental tumor M3. A total of 88 from 1,176 genes were differentially expressed in MM3 primary cultures, most of them (n=86) were upregulated. Genes were grouped according to their functions as associated with signal transduction and transcription regulation (e.g. Stat1 and Zfp 92), with cell adhesion and motility (cadherin 1, fibronectin), with invasion and angiogenesis (uPA, 72 kDa MMP2), with the regulation of cell proliferation and cell death (cyclins G and A2, TNF), and also included growth factors and receptors, oncogenes and tumor suppressors genes (p107, TGFβ2, TBR-I, PDGFR). Only 2 genes, TTF1 and fibronectin (FN), showed a significant downregulation. Notably FN expression, loss of which has been associated with a malignant phenotype, was reduced about 19-fold in the more metastatic MM3 cells. Previously known differences in expression patterns associated with the metastatic capacity of MM3 and M3 adenocarcinomas, including downregulation of FN or upregulated expression of TGFβ and proteases, were confirmed by the array data. The fact that FN was one of the only two genes significantly down-regulated out of the 1,176 genes analyzed stresses the hypothesis that FN may behave as an important metastasis suppressor gene in mammary cancer.

Registro:

Documento: Artículo
Título:Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential
Autor:Urtreger, A.J.; Werbajh, S.E.; Verrecchia, F.; Mauviel, A.; Puricelli, L.I.; Kornblihtt, A.R.; Bal De Kier Joffé, E.D.
Filiación:Área Investigación, Instituto de Oncología 'Ángel H. Roffo', Universidad de Buenos Aires, Buenos Aires, Argentina
Departamento de Fisiología, Biología Molecular Y Celular, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
Institut de Recherche Sur la Peau, Université Paris VII, Hôpital Saint Louis, 75010 Paris, France
Palabras clave:cDNA arrays; Fibronectin; Metastasizing ability; Murine mammary adenocarcinoma; fibronectin; adenocarcinoma; animal; article; comparative study; DNA microarray; down regulation; experimental neoplasm; female; gene expression; gene expression profiling; gene expression regulation; genetics; metabolism; metastasis; mouse; pathology; Western blotting; Adenocarcinoma; Animals; Blotting, Western; Down-Regulation; Female; Fibronectins; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Mammary Neoplasms, Experimental; Mice; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis
Año:2006
Volumen:16
Número:6
Página de inicio:1403
Página de fin:1410
Título revista:Oncology Reports
Título revista abreviado:Oncol. Rep.
ISSN:1021335X
CODEN:OCRPE
CAS:fibronectin, 86088-83-7; Fibronectins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1021335X_v16_n6_p1403_Urtreger

Referencias:

  • Condeelis, J., Singer, R.H., Segall, J.E., The great escape: When cancer cells hijack the genes for chemotaxis and motility (2005) Annual Review of Cell and Developmental Biology, 21, pp. 695-718. , DOI 10.1146/annurev.cellbio.21.122303.120306
  • Wittekind, C., Neid, M., Cancer invasion and metastasis (2005) Oncology, 69 (SUPPL. 1), pp. 14-16. , DOI 10.1159/000086626
  • Ludwig, T., Local proteolytic activity in tumor cell invasion and metastasis (2005) Bioessays, 27, pp. 1181-1191
  • Minn, A.J., Kang, Y., Serganova, I., Gupta, G.P., Giri, D.D., Doubrovin, M., Ponomarev, V., Massague, J., Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors (2005) Journal of Clinical Investigation, 115 (1), pp. 44-55. , DOI 10.1172/JCI200522320
  • Puricelli, L., Gomez, D.E., Del, C.V.C.M., Eijan, A.M., Spinelli, O., Alonso, D.F., De Lustig, E.S., Bal, D.K.J.E., Effect of host-organ environment on the in vivo and in vitro behavior of a murine mammary adenocarcinoma (1994) Tumor Biology, 15 (5), pp. 284-293
  • Ladeda, V., Adam, A.P., Puricelli, L., Bal, D.K.J.E., Apoptotic cell death in mammary adenocarcinoma cells is prevented by soluble factors present in the target organ of metastasis (2001) Breast Cancer Research and Treatment, 69 (1), pp. 39-51. , DOI 10.1023/A:1012201805486
  • Henrique, R., Jeronimo, C., Teixeira, M.R., Hoque, M.O., Carvalho, A.L., Pais, I., Ribeiro, F.R., Sidransky, D., Epigenetic heterogeneity of high-grade prostatic intraepithelial neoplasia: Clues for clonal progression in prostate carcinogenesis (2006) Molecular Cancer Research, 4 (1), pp. 1-8. , DOI 10.1158/1541-7786.MCR-05-0113
  • Fidler, I.J., Tumor heterogeneity and the biology of cancer invasion and metastasis (1978) Cancer Res, 38, pp. 2651-2660
  • Bal, D.K.J.E., Puricelli, L.I., Vidal, D.M.C.C., De Lustig, E.S., Characterization of two murine mammary adenocarcinoma tumors with different metastatic ability (1983) Journal of Experimental and Clinical Cancer Research, 2 (2), pp. 151-160
  • Urtreger, A.J., Ladeda, V.E., Puricelli, L.I., Rivelli, A., Del, C.V.M., De Lustig, E.S., De Bal, K.J.E.D., Modulation of fibronectin expression and proteolytic activity associated with the invasive and metastatic phenotype in two new murine mammary tumor cell lines (1997) International Journal of Oncology, 11 (3), pp. 489-496
  • Werbajh, S.E., Urtreger, A.J., Puricelli, L.I., De Lustig, E.S., Bal, D.K.J.E., Kornblihtt, A.R., Downregulation of fibronectin transcription in highly metastatic adenocarcinoma cells (1998) FEBS Letters, 440 (3), pp. 277-281. , DOI 10.1016/S0014-5793(98)01473-2, PII S0014579398014732
  • Muro, A., Puricelli, L., Kornblihtt, A.R., Bal De Kier Joffe, E., Inverse correlation between fibronectin mRNA levels and the metastatic potential of two murine mammary adenocarcinomas (1991) Invasion Metastasis, 11, pp. 281-287
  • Bal De Kier Joffe, E., Puricelli, L., De Lustig, E.S., Modified adhesion behavior after in vitro passage of two related murine mammary adenocarcinomas with different metastasizing ability (1986) Invasion Metastasis, 6, pp. 302-312
  • Pereyra-Alfonso, S., Haedo, A., Bal De Kier, J.E., Correlation between urokinase-type plasminogen activator production and the metastasizing ability of two murine mammary adenocarcinomas (1988) Int J Cancer, 42, pp. 59-63
  • Daroqui, M.C., Puricelli, L.I., Urtreger, A.J., Elizalde, P.V., Lanuza, G.M., Bal, D.K.J.E., Involvement of TGF-betas/TbetaRs system in tumor progression of murine mammary adenocarcinomas (2003) Breast Cancer Research and Treatment, 80 (3), pp. 287-301. , DOI 10.1023/A:1024910332621
  • Kaspar, M., Zardi, L., Neri, D., Fibronectin as target for tumor therapy (2006) Int J Cancer, 118, pp. 1331-1339
  • Urtreger, A., Porro, F., Puricelli, L., Werbajh, S., Baralle, F.E., De Kier, J.E.B., Kornblihtt, A.R., Muro, A.F., Expression of RGD minus fibronectin that does not form extracellular matrix fibrils is sufficient to decrease tumor metastasis (1998) International Journal of Cancer, 78 (2), pp. 233-241. , DOI 10.1002/(SICI)1097-0215(19981005)78:2<233::
  • Uehara, H., Kim, S.J., Karashima, T., Shepherd, D.L., Fan, D., Tsan, R., Killion, J.J., Fidler, I.J., Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastases (2003) Journal of the National Cancer Institute, 95 (6), pp. 458-470
  • Yu, J., Moon, A., Kim, H.-R.C., Both platelet-derived growth factor receptor (PDGFR)-alpha and PDGFR-beta promote murine fibroblast cell migration (2001) Biochemical and Biophysical Research Communications, 282 (3), pp. 697-700. , DOI 10.1006/bbrc.2001.4622
  • Stark, G.R., Kerr, I.M., Williams, B.R.G., Silverman, R.H., Schreiber, R.D., How cells respond to interferons (1998) Annual Review of Biochemistry, 67, pp. 227-264. , DOI 10.1146/annurev.biochem.67.1.227
  • Huang, S., Bucana, C.D., Van Arsdall, M., Fidler, I.J., Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells (2002) Oncogene, 21 (16), pp. 2504-2512. , DOI 10.1038/sj/onc/1205341
  • Pansky, A., Hildebrand, P., Fasler-Kan, E., Baselgia, L., Ketterer, S., Beglinger, C., Heim, M.H., Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha (2000) International Journal of Cancer, 85 (5), pp. 720-725. , DOI 10.1002/(SICI)1097-0215(20000301)85:5<720::
  • Wu, F., Li, J.Q., Miki, H., Nishioka, M., Fujita, J., Ohmori, M., Imaida, K., Kuriyama, S., p107 expression in colorectal tumours rises during carcinogenesis and falls during invasion (2002) European Journal of Cancer, 38 (14), pp. 1838-1848. , DOI 10.1016/S0959-8049(02)00146-6, PII S0959804902001466
  • Botos, J., Barhoumi, R., Burghardt, R., Kochevar, D.T., Rb localization and phosphorylation kinetics correlate with the cellular phenotype of cultured breast adenocarcinoma cells (2002) In Vitro Cellular and Developmental Biology - Animal, 38 (4), pp. 235-241. , DOI 10.1290/1071-2690(2002)038<0235:RLAPKC>2
  • Berx, G., Van Roy, F., The E-cadherin/catenin complex: An important gatekeeper in breast cancer tumorigenesis and malignant progression (2001) Breast Cancer Research, 3 (5), pp. 289-293. , DOI 10.1186/bcr309
  • Lim, S.C., Lee, M.S., Significance of E-cadherin/beta-catenin complex and cyclin D1 in breast cancer (2002) Oncol Rep, 9, pp. 915-928
  • Cavallaro, U., Christofori, G., Cell adhesion in tumor invasion and metastasis: Loss of the glue is not enough (2001) Biochimica et Biophysica Acta - Reviews on Cancer, 1552 (1), pp. 39-45. , DOI 10.1016/S0304-419X(01)00038-5, PII S0304419X01000385
  • Indinnimeo, M., Cicchini, C., Stazi, A., Limiti, M.R., Ghini, C., Mingazzini, P.L., Vecchione, A., Prognostic impact of CD31 antigen expression in anal canal carcinoma (2001) Hepato-Gastroenterology, 48 (41), pp. 1355-1358
  • Tang, D.G., Chen, Y.Q., Newman, P.J., Shi, L., Gao, X., Diglio, C.A., Honn, K.V., Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium (1993) Journal of Biological Chemistry, 268 (30), pp. 22883-22894
  • Righi, L., Deaglio, S., Pecchioni, C., Gregorini, A., Horenstein, A.L., Bussolati, G., Sapino, A., Malavasi, F., Role of CD31/platelet endothelial cell adhesion molecule-1 expression in in vitro and in vivo growth and differentiation of human breast cancer cells (2003) American Journal of Pathology, 162 (4), pp. 1163-1174
  • Alonso, D.F., Farias, E.F., Ladeda, V., Davel, L., Puricelli, L., Bal, D.K.J.E., Effects of synthetic urokinase inhibitors on local invasion and metastasis in a murine mammary tumor model (1996) Breast Cancer Research and Treatment, 40 (3), pp. 209-223. , DOI 10.1007/BF01806809
  • Monitto, C.L., Berkowitz, D., Lee, K.M., Differential gene expression in a murine model of cancer cachexia (2001) Am J Physiol Endocrinol Metab, 281, pp. E289-E297
  • Akiyama, S.K., Olden, K., Yamada, K.M., Fibronectin and integrins in invasion and metastasis (1995) Cancer Metastasis Rev, 14, pp. 173-189
  • Christensen, L., The distribution of fibronectin, laminin and tetranectin in human breast cancer with special attention to the extracellular matrix (1992) APMIS, 26 (SUPPL.), pp. 1-39
  • Wierzbicka-Patynowski, I., Schwarzbauer, J.E., The ins and outs of fibronectin matrix assembly (2003) Journal of Cell Science, 116 (16), pp. 3269-3276. , DOI 10.1242/jcs.00670
  • Akamatsu, H., Ichihara-Tanaka, K., Ozono, K., Kamiike, W., Matsuda, H., Sekiguchi, K., Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin (1996) Cancer Research, 56 (19), pp. 4541-4546
  • Zhao, H., Jhanwar-Uniyal, M., Datta, P.K., Yemul, S., Ho, L., Khitrov, G., Kupershmidt, I., Achary, M.P., Expression profile of genes associated with antimetastatic gene: NM23-mediated metastasis inhibition in breast carcinoma cells (2004) International Journal of Cancer, 109 (1), pp. 65-70. , DOI 10.1002/ijc.11676
  • Schalken, J.A., Ebeling, S.B., Isaacs, J.T., Down modulation of fibronectin messenger RNA in metastasizing rat prostatic cancer cells revealed by differential hybridization analysis (1988) Cancer Res, 48, pp. 2042-2046
  • Urtreger, A.J., Aguirre, G.J.A., Werbajh, S.E., Puricelli, L.I., Muro, A.F., Bal, D.K.J.E., Involvement of fibronectin in the regulation of urokinase production and binding in murine mammary tumor cells (1999) International Journal of Cancer, 84 (5), pp. 748-753
  • Muro, A.F., Bernath, V.A., Kornblihtt, A.R., Interaction of the -170 cyclic AMP response element with the adjacent CCAAT box in the human fibronectin gene promoter (1992) J Biol Chem, 267, pp. 12767-12774
  • Wasenius, V.-M., Hemmer, S., Kettunen, E., Knuutila, S., Franssila, K., Joensuu, H., Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: A cDNA and tissue microarray study (2003) Clinical Cancer Research, 9 (1 I), pp. 68-75
  • Mackay, A., Jones, C., Dexter, T., Silva, R.L.A., Bulmer, K., Jones, A., Simpson, P., O'Hare, M.J., cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells (2003) Oncogene, 22 (17), pp. 2680-2688. , DOI 10.1038/sj.onc.1206349
  • Hao, X., Sun, B., Hu, L., Lahdesmaki, H., Dunmire, V., Feng, Y., Zhang, S.-W., Zhang, W., Differential Gene and Protein Expression in Primary Breast Malignancies and Their Lymph Node Metastases as Revealed by Combined cDNA Microarray and Tissue Microarray Analysis (2004) Cancer, 100 (6), pp. 1110-1122. , DOI 10.1002/cncr.20095

Citas:

---------- APA ----------
Urtreger, A.J., Werbajh, S.E., Verrecchia, F., Mauviel, A., Puricelli, L.I., Kornblihtt, A.R. & Bal De Kier Joffé, E.D. (2006) . Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential. Oncology Reports, 16(6), 1403-1410.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1021335X_v16_n6_p1403_Urtreger [ ]
---------- CHICAGO ----------
Urtreger, A.J., Werbajh, S.E., Verrecchia, F., Mauviel, A., Puricelli, L.I., Kornblihtt, A.R., et al. "Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential" . Oncology Reports 16, no. 6 (2006) : 1403-1410.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1021335X_v16_n6_p1403_Urtreger [ ]
---------- MLA ----------
Urtreger, A.J., Werbajh, S.E., Verrecchia, F., Mauviel, A., Puricelli, L.I., Kornblihtt, A.R., et al. "Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential" . Oncology Reports, vol. 16, no. 6, 2006, pp. 1403-1410.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1021335X_v16_n6_p1403_Urtreger [ ]
---------- VANCOUVER ----------
Urtreger, A.J., Werbajh, S.E., Verrecchia, F., Mauviel, A., Puricelli, L.I., Kornblihtt, A.R., et al. Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential. Oncol. Rep. 2006;16(6):1403-1410.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1021335X_v16_n6_p1403_Urtreger [ ]