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Sacca, P.A.; Creydt, V.P.; Choi, H.; Mazza, O.N.; Fletcher, S.J.; Vallone, V.B.F.; Scorticati, C.; Chasseing, N.A.; Calvo, J.C. "Human periprostatic adipose tissue: Its influence on prostate cancer cells" (2012) Cellular Physiology and Biochemistry. 30(1):113-122
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Abstract:

Background/Aims: Adipose microenvironment is involved in signaling pathways that influence prostate cancer (PCa) progression. However, the role of human periprostatic adipose tissue (PPAT) from patients with benign prostatic hyperplasia (BPH) has not been studied and compared to that of PPAT from PCa patients. The aim of this paper was to investigate the influence of factors derived from both PPATs on the behavior of androgen-dependent and castration resistant PCa cells. Methods: PPAT conditioned media (CM) were obtained from tissue samples from patients with clinically primary PCa (TPPAT) or BPH (BPPAT). Cell adhesion, proliferation, migration and metalloproteinase expression were evaluated following exposure of LNCaP (androgen dependent) and PC3 (androgen independent) prostate cancer cell lines to BPPAT or TPPAT CM. Results: Proliferation or motility of LNCaP or PC3 cells were not significantly affected by TPPAT or BPPAT CM. The number of LNCaP but not PC3 cells attached to components of TPPAT CM significantly decreased compared to cells attached to BPPAT CM. PPAT produced and released pro-MMP-9. Zymograms demonstrated that TPPAT CM induced a significant increase in pro-MMP-9 activity compared to BPPAT CM in LNCaP cells but not in PC3 cells. Conclusions: We conclude that TPPAT released factors, such as pro-MMP-9, could induce the invasive capacity of LNCaP cells and speculate that PPAT derived factors could, in the early stages of prostate cancer, modulate disease progression. © 2012 S. Karger AG, Basel.

Registro:

Documento: Artículo
Título:Human periprostatic adipose tissue: Its influence on prostate cancer cells
Autor:Sacca, P.A.; Creydt, V.P.; Choi, H.; Mazza, O.N.; Fletcher, S.J.; Vallone, V.B.F.; Scorticati, C.; Chasseing, N.A.; Calvo, J.C.
Filiación:Instituto de Biologa y Medicina Experimental (IBYME)-CONICET, Vuelta de Obligado 2490, 1428 Ciudad de Buenos Aires, Argentina
Institute for Regenerative Medicine, Texas A and M Health Science Center, Temple, TX, United States
Hospital de Clnicas Jos de San Martn-Ctedra de Urologa, Facultad de Medicina, Universidad de Buenos Aires, Argentina
Departamento de Qumica Biolgica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Adipose tissue; Metalloproteinases; Microenvironment; Periprostatic adipose tissue; Periprostatic fat; Prostate cancer; androgen; gelatinase B; adipose tissue; adult; aged; article; cancer cell; cancer surgery; castration resistant prostate cancer; cell adhesion; cell migration; cell motility; cell proliferation; cell strain LNCaP; controlled study; enzyme activity; human; human cell; human tissue; male; periprostatic adipose tissue; priority journal; prostate hypertrophy; prostatectomy; protein expression; zymography; Aged; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Culture Media, Conditioned; Humans; Intra-Abdominal Fat; Male; Matrix Metalloproteinase 9; Middle Aged; Neoplasms, Hormone-Dependent; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; Tumor Microenvironment
Año:2012
Volumen:30
Número:1
Página de inicio:113
Página de fin:122
DOI: http://dx.doi.org/10.1159/000339051
Título revista:Cellular Physiology and Biochemistry
Título revista abreviado:Cell. Physiol. Biochem.
ISSN:10158987
CODEN:CEPBE
CAS:gelatinase B, 146480-36-6; Culture Media, Conditioned; Matrix Metalloproteinase 9, 3.4.24.35
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10158987_v30_n1_p113_Sacca

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Citas:

---------- APA ----------
Sacca, P.A., Creydt, V.P., Choi, H., Mazza, O.N., Fletcher, S.J., Vallone, V.B.F., Scorticati, C.,..., Calvo, J.C. (2012) . Human periprostatic adipose tissue: Its influence on prostate cancer cells. Cellular Physiology and Biochemistry, 30(1), 113-122.
http://dx.doi.org/10.1159/000339051
---------- CHICAGO ----------
Sacca, P.A., Creydt, V.P., Choi, H., Mazza, O.N., Fletcher, S.J., Vallone, V.B.F., et al. "Human periprostatic adipose tissue: Its influence on prostate cancer cells" . Cellular Physiology and Biochemistry 30, no. 1 (2012) : 113-122.
http://dx.doi.org/10.1159/000339051
---------- MLA ----------
Sacca, P.A., Creydt, V.P., Choi, H., Mazza, O.N., Fletcher, S.J., Vallone, V.B.F., et al. "Human periprostatic adipose tissue: Its influence on prostate cancer cells" . Cellular Physiology and Biochemistry, vol. 30, no. 1, 2012, pp. 113-122.
http://dx.doi.org/10.1159/000339051
---------- VANCOUVER ----------
Sacca, P.A., Creydt, V.P., Choi, H., Mazza, O.N., Fletcher, S.J., Vallone, V.B.F., et al. Human periprostatic adipose tissue: Its influence on prostate cancer cells. Cell. Physiol. Biochem. 2012;30(1):113-122.
http://dx.doi.org/10.1159/000339051