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Abstract:

Porphyrins are the only and most powerful photosensitizers synthesized internally. To understand better the involvement of porphyrins in photosensitization reactions, the heme biosynthetic pathway is first described, as well as the main features of its regulation in both erythroid and hepatic cells. Most disorders of porphyrin metabolism, known as porphyrias, are characterized by porphyrin accumulation. A full discussion of these diseases, their classification and relevant biochemical and clinical signs are presented. Abnormalities in heme biosynthesis in disorders other than porphyrias, such as iron-deficient and sideroblastic anemias, lead poisoning, hereditary tyrosinemia, chronic renal disease and alcoholism, are briefly considered. A complete survey of the experimental research on the biosynthesis of porphyrins in tumors and of the important association between cancer and porphyrias is dealt with. The link to photodynamic therapy (PDT) emerges naturally and this is treated from the point of view of using porphyrins endogenously formed by the tumors for their localization and PDT. Finally, considering the nature of the alterations occurring in heme metabolism in tumors, and porphyrias and their ubiquity, a model is discussed where the abnormality of heme synthesis is involved in the initiating lesion of carcinogenesis. The model strongly predicts that the incidence of cancer will be high in cells with abnormal heme metabolism, suggesting that porphyric patients may be at greater risk of the development of cancer. © 1993.

Registro:

Documento: Artículo
Título:Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis
Autor:Del Batlle, C.A.M.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias - CIPYP, CONICET - FCEN, UBA, Viamonte 1881 10A, 1056 Buenos Aires, Argentina
Palabras clave:Cancer; Carcinogenesis; Photodynamic therapy; Porphyrias; Porphyrins; aminolevulinic acid; hematoporphyrin derivative; photosensitizing agent; phthalocyanine derivative; porphyrin; carcinogenesis; heme synthesis; human; intratumoral drug administration; photodynamic therapy; porphyria; review; Aminolevulinic Acid; Heme; Human; Models, Biological; Neoplasms; Photochemotherapy; Porphyria; Porphyrins; Support, Non-U.S. Gov't
Año:1993
Volumen:20
Número:1
Página de inicio:5
Página de fin:22
DOI: http://dx.doi.org/10.1016/1011-1344(93)80127-U
Título revista:Journal of Photochemistry and Photobiology, B: Biology
Título revista abreviado:J. Photochem. Photobiol. B Biol.
ISSN:10111344
CODEN:JPPBE
CAS:aminolevulinic acid, 106-60-5; porphyrin, 24869-67-8; Aminolevulinic Acid, 106-60-5; Heme, 14875-96-8; Porphyrins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10111344_v20_n1_p5_DelBatlle

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Citas:

---------- APA ----------
(1993) . Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis. Journal of Photochemistry and Photobiology, B: Biology, 20(1), 5-22.
http://dx.doi.org/10.1016/1011-1344(93)80127-U
---------- CHICAGO ----------
Del Batlle, C.A.M. "Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis" . Journal of Photochemistry and Photobiology, B: Biology 20, no. 1 (1993) : 5-22.
http://dx.doi.org/10.1016/1011-1344(93)80127-U
---------- MLA ----------
Del Batlle, C.A.M. "Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis" . Journal of Photochemistry and Photobiology, B: Biology, vol. 20, no. 1, 1993, pp. 5-22.
http://dx.doi.org/10.1016/1011-1344(93)80127-U
---------- VANCOUVER ----------
Del Batlle, C.A.M. Porphyrins, porphyrias, cancer and photodynamic therapy - a model for carcinogenesis. J. Photochem. Photobiol. B Biol. 1993;20(1):5-22.
http://dx.doi.org/10.1016/1011-1344(93)80127-U