Artículo

López Zeballos, N.C.; Gauna, G.A.; García Vior, M.C.; Awruch, J.; Dicelio, L.E. "Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents" (2014) Journal of Photochemistry and Photobiology B: Biology. 136:29-33
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Abstract:

The interaction of novel zinc (II) cationic phthalocyanines with CT-DNA was studied using absorption and fluorescence spectroscopy, as well as thermal denaturation profiles. Results showed an electrostatic interaction between the phthalocyanines and CT-DNA. The properties of these phthalocyanines were compared taking the structure of the macrocycle peripheral substituents into account. 2,9(10),16(17),23(24)-tetrakis[(N-butyl-N-methylammonium)ethylsulfanyl] phthalocyaninatozinc(II) tetraiodide (Pc6) had a greater affinity for the CT-DNA helix than its bioisoster 2,9(10),16(17),23(24)-tetrakis[(N-dibutyl-N- methylammonium)ethoxy]phthalocyaninatozinc(II) tetraiodide (Pc7). 2,9(10),16(17),23(24)-tetrakis[(2-trimethylammonium)ethyl-sulfanyl] phthalocyaninatozinc(II) tetraiodide (Pc13) also carried a sulfur atom like Pc6, but linked to bulky substituents such as trimethylammonium groups. The planar aromatic region of the cationic phthalocyanines in this study appears to be unable to facilitate their intercalation with CT-DNA. © 2014 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents
Autor:López Zeballos, N.C.; Gauna, G.A.; García Vior, M.C.; Awruch, J.; Dicelio, L.E.
Filiación:Departamento de Química Inorgánica, Analítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina
Palabras clave:Aggregation; Calf thymus DNA; Fluorescence; Phthalocyanines; 2,9(10),16(17),23(24) tetrakis [(n butyl n methylammonium)ethylsulfanyl]phthalocyaninatozinc(II) tetraiodide; 2,9(10),16(17),23(24) tetrakis[(2 trimethylammonium)ethyl sulfanyl]phthalocyaninatozinc(II) tetraioide; 2,9(10),16(17),23(24) tetrakis[(n dibutyl n methylammonium)ethoxy]phthalocyaninatozinc(II) tetraiodide; cation; DNA; dye; iodide; macrocyclic compound; phthalocyanine; sulfur; trimethylammonium salt derivative; unclassified drug; zinc; calf thymus DNA; cation; DNA; indole derivative; phthalocyanine; absorption; article; binding affinity; chemical structure; denaturation; DNA binding; DNA helix; fluorescence spectroscopy; priority journal; static electricity; thymus; chemistry; DNA denaturation; heat; spectrofluorometry; ultraviolet spectrophotometry; Cations; DNA; Hot Temperature; Indoles; Nucleic Acid Denaturation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet
Año:2014
Volumen:136
Página de inicio:29
Página de fin:33
DOI: http://dx.doi.org/10.1016/j.jphotobiol.2014.04.013
Título revista:Journal of Photochemistry and Photobiology B: Biology
Título revista abreviado:J. Photochem. Photobiol. B Biol.
ISSN:10111344
CODEN:JPPBE
CAS:DNA, 9007-49-2; iodide, 20461-54-5; phthalocyanine, 574-93-6; sulfur, 13981-57-2, 7704-34-9; trimethylammonium salt derivative, 16962-53-1; zinc, 7440-66-6, 14378-32-6; calf thymus DNA; Cations; DNA; Indoles; phthalocyanine
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10111344_v136_n_p29_LopezZeballos

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Citas:

---------- APA ----------
López Zeballos, N.C., Gauna, G.A., García Vior, M.C., Awruch, J. & Dicelio, L.E. (2014) . Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents. Journal of Photochemistry and Photobiology B: Biology, 136, 29-33.
http://dx.doi.org/10.1016/j.jphotobiol.2014.04.013
---------- CHICAGO ----------
López Zeballos, N.C., Gauna, G.A., García Vior, M.C., Awruch, J., Dicelio, L.E. "Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents" . Journal of Photochemistry and Photobiology B: Biology 136 (2014) : 29-33.
http://dx.doi.org/10.1016/j.jphotobiol.2014.04.013
---------- MLA ----------
López Zeballos, N.C., Gauna, G.A., García Vior, M.C., Awruch, J., Dicelio, L.E. "Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents" . Journal of Photochemistry and Photobiology B: Biology, vol. 136, 2014, pp. 29-33.
http://dx.doi.org/10.1016/j.jphotobiol.2014.04.013
---------- VANCOUVER ----------
López Zeballos, N.C., Gauna, G.A., García Vior, M.C., Awruch, J., Dicelio, L.E. Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents. J. Photochem. Photobiol. B Biol. 2014;136:29-33.
http://dx.doi.org/10.1016/j.jphotobiol.2014.04.013