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Abstract:

The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis- (1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in order to evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropic properties and stability of liposomes during a time period. Liposomes were prepared by the thin-layer evaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellar vesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficiently into all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEG liposomal formulation showed the lowest aggregation value. The average diameter of liposomes with different lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differences between the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol (PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increased the stability of liposomes for at least 9 months. After a long storage, the most stable formulations were those without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values were higher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC) liposomes or Tween 80. © 2012 Elsevier B.V.

Registro:

Documento: Artículo
Título:An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
Autor:López Zeballos, N.C.; García Vior, M.C.; Awruch, J.; Dicelio, L.E.
Filiación:INQUIMAE, Departamento de Química Inorgánica, Analítica y Química Física, Pabellón II, 1428 Buenos Aires, Argentina
Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina
Palabras clave:Carriers; Liposomes; Phthalocyanines; Singlet oxygen; Stability
Año:2012
Volumen:235
Página de inicio:7
Página de fin:13
DOI: http://dx.doi.org/10.1016/j.jphotochem.2012.02.022
Título revista:Journal of Photochemistry and Photobiology A: Chemistry
Título revista abreviado:J. Photochem. Photobiol. A Chem.
ISSN:10106030
CODEN:JPPCE
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10106030_v235_n_p7_LopezZeballos

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Citas:

---------- APA ----------
López Zeballos, N.C., García Vior, M.C., Awruch, J. & Dicelio, L.E. (2012) . An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes. Journal of Photochemistry and Photobiology A: Chemistry, 235, 7-13.
http://dx.doi.org/10.1016/j.jphotochem.2012.02.022
---------- CHICAGO ----------
López Zeballos, N.C., García Vior, M.C., Awruch, J., Dicelio, L.E. "An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes" . Journal of Photochemistry and Photobiology A: Chemistry 235 (2012) : 7-13.
http://dx.doi.org/10.1016/j.jphotochem.2012.02.022
---------- MLA ----------
López Zeballos, N.C., García Vior, M.C., Awruch, J., Dicelio, L.E. "An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes" . Journal of Photochemistry and Photobiology A: Chemistry, vol. 235, 2012, pp. 7-13.
http://dx.doi.org/10.1016/j.jphotochem.2012.02.022
---------- VANCOUVER ----------
López Zeballos, N.C., García Vior, M.C., Awruch, J., Dicelio, L.E. An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes. J. Photochem. Photobiol. A Chem. 2012;235:7-13.
http://dx.doi.org/10.1016/j.jphotochem.2012.02.022