Artículo

De Cidre, L.L.; Eijan, A.M.; Bertolesi, G.; Isturiz, M.; De Lustig, E.S. "Influence of mast cells on two murine mammary adenocarcinomas" (1996) Tumor Biology. 17(6):345-353
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Abstract:

A high content of mast cells (MC) is considered characteristic of neoplasias. Some researchers postulate MC as enhancers of tumor development, others as inhibitors. The purpose of this study was to evaluate the ability of peritoneal cavity MC to modulate the in vivo and in vitro growth of two murine mammary adenocarcinomas with low (M3) and high (MM3) meta-static capacity. MC from the peritoneal cavity of normal (NMC) or tumor-bearing mice (TMC) were used. TMC, which by histochemical methods appeared degranulated, were not able to modify the tumorigenicity of both tumors. NMC, in contrast, decreased M3 tumor incidence and cell proliferation in vitro and increased the latency period of only MM3 tumors. No changes in the number of spontaneous lung metastases could be seen in experiments carried out either with NMC or TMC. We conclude that NMC, which are rich in chemical mediators, can modulate some of the first steps of tumor development. Once tumor-mediated degranulation occurs, MC become unable to regulate it. © 1996 S. Karger AG, Basel.

Registro:

Documento: Artículo
Título:Influence of mast cells on two murine mammary adenocarcinomas
Autor:De Cidre, L.L.; Eijan, A.M.; Bertolesi, G.; Isturiz, M.; De Lustig, E.S.
Filiación:Departamento de Ciencias Biológicas, Histología Animal, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Instituto de Oncología ‘A. Roffo’, Departamento de Investigaciones, Facultad de Medicina, Universidad de Buenos Aires, Argentina
Division Inmunología IIHEMA, Academia Nacional de Medicina, Buenos Aires, Argentina
Palabras clave:Adenocarcinoma; Heparin; Mast cells; Tumor cell growth; animal cell; animal experiment; animal model; article; breast carcinoma; cell interaction; controlled study; female; lung metastasis; mast cell; mouse; nonhuman; priority journal
Año:1996
Volumen:17
Número:6
Página de inicio:345
Página de fin:353
DOI: http://dx.doi.org/10.1159/000217999
Título revista:Tumor Biology
Título revista abreviado:Tumor Biol.
ISSN:10104283
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10104283_v17_n6_p345_DeCidre

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Citas:

---------- APA ----------
De Cidre, L.L., Eijan, A.M., Bertolesi, G., Isturiz, M. & De Lustig, E.S. (1996) . Influence of mast cells on two murine mammary adenocarcinomas. Tumor Biology, 17(6), 345-353.
http://dx.doi.org/10.1159/000217999
---------- CHICAGO ----------
De Cidre, L.L., Eijan, A.M., Bertolesi, G., Isturiz, M., De Lustig, E.S. "Influence of mast cells on two murine mammary adenocarcinomas" . Tumor Biology 17, no. 6 (1996) : 345-353.
http://dx.doi.org/10.1159/000217999
---------- MLA ----------
De Cidre, L.L., Eijan, A.M., Bertolesi, G., Isturiz, M., De Lustig, E.S. "Influence of mast cells on two murine mammary adenocarcinomas" . Tumor Biology, vol. 17, no. 6, 1996, pp. 345-353.
http://dx.doi.org/10.1159/000217999
---------- VANCOUVER ----------
De Cidre, L.L., Eijan, A.M., Bertolesi, G., Isturiz, M., De Lustig, E.S. Influence of mast cells on two murine mammary adenocarcinomas. Tumor Biol. 1996;17(6):345-353.
http://dx.doi.org/10.1159/000217999