Abstract:
The functional role of the long-lasting inflammation found in the substantia nigra (SN) of Parkinson's disease (PD) patients and animal models is unclear. Proinflammatory cytokines such as interleukin-1β (IL-1β) could be involved in mediating neuronal demise. However, it is unknown whether the chronic expression of cytokines such as IL-1β in the SN can alter neuronal vitality. The aim of this study was to investigate the effects of the chronic expression of IL-1β in the adult rat SN using a recombinant adenovirus expressing IL-1β. The chronic expression of IL-1β for 60 days induced dopaminergic cell death in the SN and unilateral akinesia starting only at 21 days post-injection. Microglial cell activation and inflammatory cell infiltrate were associated with dopaminergic cell death and motor disabilities. Astrocytic activation was delayed and associated with scar formation. The chronic expression of a single proinflammatory cytokine as IL-1β in the SN elicited most of the characteristics of PD, including progressive dopaminergic cell death, akinesia and glial activation. Our data suggest that IL-1β per se is able to mediate inflammatory-mediated toxic effects in the SN if its expression is sustained. This model will be helpful to identify possible therapeutic targets related to inflammation-derived neurodegeneration in the SN. © 2006 Elsevier Inc. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1β in the substantia nigra |
Autor: | Ferrari, C.C.; Pott Godoy, M.C.; Tarelli, R.; Chertoff, M.; Depino, A.M.; Pitossi, F.J. |
Filiación: | Institute Leloir, IIBBA-CONICET, FBMC-FCEyN, Ave. Patricias Argentinas 435, 1405 Buenos Aires, Argentina
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Palabras clave: | Adenovector; Akinesia; Cytokine; Inflammation; Microglia; Parkinson; interleukin 1beta; Adenovirus; akinesia; animal experiment; animal model; animal tissue; article; astrocyte; cell activation; cell death; controlled study; disease course; dopaminergic nerve cell; immunohistochemistry; inflammatory infiltrate; male; microglia; motor dysfunction; nerve degeneration; nonhuman; pathogenesis; pathophysiology; priority journal; protein expression; rat; scar formation; substantia nigra; virus recombinant; Adenoviridae; Animals; Astrocytes; Cell Death; Cytokines; Dopamine; Genetic Vectors; Glial Fibrillary Acidic Protein; Interleukin-1; Macrophage Activation; Macrophages; Male; Microglia; Motor Activity; Movement Disorders; Nerve Degeneration; Neuroglia; Neurons; Parkinson Disease, Secondary; Rats; Rats, Wistar; Substantia Nigra |
Año: | 2006
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Volumen: | 24
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Número: | 1
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Página de inicio: | 183
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Página de fin: | 193
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DOI: |
http://dx.doi.org/10.1016/j.nbd.2006.06.013 |
Título revista: | Neurobiology of Disease
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Título revista abreviado: | Neurobiol. Dis.
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ISSN: | 09699961
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CODEN: | NUDIE
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CAS: | Cytokines; Dopamine, 51-61-6; Glial Fibrillary Acidic Protein; Interleukin-1
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09699961_v24_n1_p183_Ferrari |
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Citas:
---------- APA ----------
Ferrari, C.C., Pott Godoy, M.C., Tarelli, R., Chertoff, M., Depino, A.M. & Pitossi, F.J.
(2006)
. Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1β in the substantia nigra. Neurobiology of Disease, 24(1), 183-193.
http://dx.doi.org/10.1016/j.nbd.2006.06.013---------- CHICAGO ----------
Ferrari, C.C., Pott Godoy, M.C., Tarelli, R., Chertoff, M., Depino, A.M., Pitossi, F.J.
"Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1β in the substantia nigra"
. Neurobiology of Disease 24, no. 1
(2006) : 183-193.
http://dx.doi.org/10.1016/j.nbd.2006.06.013---------- MLA ----------
Ferrari, C.C., Pott Godoy, M.C., Tarelli, R., Chertoff, M., Depino, A.M., Pitossi, F.J.
"Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1β in the substantia nigra"
. Neurobiology of Disease, vol. 24, no. 1, 2006, pp. 183-193.
http://dx.doi.org/10.1016/j.nbd.2006.06.013---------- VANCOUVER ----------
Ferrari, C.C., Pott Godoy, M.C., Tarelli, R., Chertoff, M., Depino, A.M., Pitossi, F.J. Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1β in the substantia nigra. Neurobiol. Dis. 2006;24(1):183-193.
http://dx.doi.org/10.1016/j.nbd.2006.06.013