Artículo
Kovensky, J.; Duchaussoy, P.; Bono, F.; Salmivirta, M.; Sizun, P.; Herbert, J.-M.; Petitou, M.; Sinaÿ, P. "A synthetic heparan sulfate pentasaccharide, exclusively containing L-iduronic acid, displays higher affinity for FGF-2 than its D-glucuronic acid-containing isomers" (1999) Bioorganic and Medicinal Chemistry. 7(8):1567-1580
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Abstract:
It has been suggested that the FGF-2 binding site on heparan sulfate chains is a trisulfated pentasaccharide containing three hexuronic acid units. The configuration at C-5 of two of them being undetermined, we have synthesized the four possible pentasaccharides, and have evaluated their FGF-2 binding affinity through in vitro biological assays. The pentasaccharide containing L-iduronic acid as the sole hexuronic acid showed higher affinity for FGF-2 than the other pentasaccharides, where one hexuronic acid unit at least is D-glucuronic acid. Copyright (C) 1999.
Registro:
| Documento: | Artículo |
| Título: | A synthetic heparan sulfate pentasaccharide, exclusively containing L-iduronic acid, displays higher affinity for FGF-2 than its D-glucuronic acid-containing isomers |
| Autor: | Kovensky, J.; Duchaussoy, P.; Bono, F.; Salmivirta, M.; Sizun, P.; Herbert, J.-M.; Petitou, M.; Sinaÿ, P. |
| Filiación: | Ecole Normale Supérieure, Département de Chimie, Associé au CNRS, 24 rue Lhomond, 75231 Paris Cedex 05, France Sanofi Recherche, Haemobiology Research Department, 135 route d'Espagne, 31036 Toulouse Cedex, France Uppsala University, Dept. Med. and Physiological Chem., Biomedical Center, PO Box 575, S-75123 Uppsala, Sweden Sanofi Recherche, Exploratory Research Department, 371 rue du Professeur Joseph Blayac, 34184 Montpellier Cedex, France Depto. de Quim. Orgánica, Fac. de Ciencias Exactas y Naturales, Cd. Univ.-Pabellon II-3o, 1428 Buenos Aires, Argentina |
| Palabras clave: | Carbohydrates; Glycosylation; Growth factors; Heparan sulfate; fibroblast growth factor 2; heparan sulfate; pentasaccharide; aorta; article; binding affinity; binding site; chemical structure; controlled study; human; human cell; intestine; synthesis; Aorta; Binding Sites; Carbohydrate Sequence; Cell Division; Cells, Cultured; Fibroblast Growth Factor 2; Glucuronic Acid; Heparitin Sulfate; Humans; Iduronic Acid; Isomerism; Molecular Sequence Data; Muscle, Smooth, Vascular; Oligosaccharides |
| Año: | 1999 |
| Volumen: | 7 |
| Número: | 8 |
| Página de inicio: | 1567 |
| Página de fin: | 1580 |
| DOI: | http://dx.doi.org/10.1016/S0968-0896(99)00106-6 |
| Título revista: | Bioorganic and Medicinal Chemistry |
| Título revista abreviado: | Bioorg. Med. Chem. |
| ISSN: | 09680896 |
| CODEN: | BMECE |
| CAS: | Fibroblast Growth Factor 2, 103107-01-3; Glucuronic Acid, 576-37-4; Heparitin Sulfate, 9050-30-0; Iduronic Acid, 3402-98-0; Oligosaccharides |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09680896_v7_n8_p1567_Kovensky |
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Citas:
---------- APA ----------
Kovensky, J., Duchaussoy, P., Bono, F., Salmivirta, M., Sizun, P., Herbert, J.-M., Petitou, M.,..., Sinaÿ, P. (1999) . A synthetic heparan sulfate pentasaccharide, exclusively containing L-iduronic acid, displays higher affinity for FGF-2 than its D-glucuronic acid-containing isomers. Bioorganic and Medicinal Chemistry, 7(8), 1567-1580.http://dx.doi.org/10.1016/S0968-0896(99)00106-6
---------- CHICAGO ----------
Kovensky, J., Duchaussoy, P., Bono, F., Salmivirta, M., Sizun, P., Herbert, J.-M., et al. "A synthetic heparan sulfate pentasaccharide, exclusively containing L-iduronic acid, displays higher affinity for FGF-2 than its D-glucuronic acid-containing isomers" . Bioorganic and Medicinal Chemistry 7, no. 8 (1999) : 1567-1580.http://dx.doi.org/10.1016/S0968-0896(99)00106-6
---------- MLA ----------
Kovensky, J., Duchaussoy, P., Bono, F., Salmivirta, M., Sizun, P., Herbert, J.-M., et al. "A synthetic heparan sulfate pentasaccharide, exclusively containing L-iduronic acid, displays higher affinity for FGF-2 than its D-glucuronic acid-containing isomers" . Bioorganic and Medicinal Chemistry, vol. 7, no. 8, 1999, pp. 1567-1580.http://dx.doi.org/10.1016/S0968-0896(99)00106-6
---------- VANCOUVER ----------
Kovensky, J., Duchaussoy, P., Bono, F., Salmivirta, M., Sizun, P., Herbert, J.-M., et al. A synthetic heparan sulfate pentasaccharide, exclusively containing L-iduronic acid, displays higher affinity for FGF-2 than its D-glucuronic acid-containing isomers. Bioorg. Med. Chem. 1999;7(8):1567-1580.http://dx.doi.org/10.1016/S0968-0896(99)00106-6
