Artículo
Alché, L.E.; Berra, A.; Coto, C.E. "Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral" (2001) International Antiviral News. 9(8):132-135
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Abstract:
Recurrent herpes simplex virus (HSV) infections of the eye result in corneal damage and eventually loss of vision. Therefore, there is a continuing need to develop new antiviral drugs. Our laboratory is engaged in searching for natural compounds with antiviral activity. We previously reported that meliacine (MA), a partially purified compound isolated from crude leaf extracts from Melia azedarach L., effectively inhibits HSV-I multiplication in vitro when added before or after infection. Our present findings indicate that MA prevents the development of murine herpetic stromal keratitis by affecting both viral yields in the eyes as well as the incidence and severity of the signs of disease, when administered topically either before or after infection, with no toxic effects [I].
Registro:
| Documento: | Artículo |
| Título: | Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral |
| Autor: | Alché, L.E.; Berra, A.; Coto, C.E. |
| Filiación: | Laboratorio de Virología, Depto Quimica Biologica, Fac. de Ciencias Exactas y Naturales, Buenos Aires, Argentina |
| Palabras clave: | antivirus agent; meliacine; plant extract; unclassified drug; animal experiment; animal model; animal tissue; antiviral activity; cellular immunity; controlled study; cornea injury; disease severity; drug effect; drug efficacy; drug mechanism; herpes simplex keratitis; Herpes simplex virus; in vitro study; melia azedarach; mouse; nonhuman; plant; review; T lymphocyte; treatment outcome; virus adsorption; virus load; virus replication; visual impairment |
| Año: | 2001 |
| Volumen: | 9 |
| Número: | 8 |
| Página de inicio: | 132 |
| Página de fin: | 135 |
| Título revista: | International Antiviral News |
| Título revista abreviado: | Int. Antiviral News |
| ISSN: | 09652310 |
| CODEN: | IANWE |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09652310_v9_n8_p132_Alche |
Referencias:
- Alché, L.E., Berra, A., Veloso, M.J., Coto, C.E., Treatment with meliacine, a plant derived antiviral, prevents the development of herpatic stromal keratitis in mice (2000) Journal of Medical Virology, 61, pp. 474-480
- Wachsman, M.B., Martino, V., Coto, C.E., Search for antiviral activity in higher plant extracts (1988) Fitoterapia, 59, pp. 422-424
- Andrei, G., Couto, A.S., Lederkremer, R.M., Coto, C.E., Purification and partial characterization of an antiviral active peptide from Melia azedarach L (1994) Antiviral Chemistry & Chemotherapy, 5, pp. 105-110
- Villamil, S.M., Alché, L.E., Coto, C.E., Inhibition of herpes simplex virus type 1 multiplication by meliacine, a peptide of plant origin (1995) Antiviral Chemistry & Chemotherapy, 6, pp. 239-244
- Barquero, A.A., Alché, L.E., Coto, C.E., Antiviral activity of meliacine on the replication of a thymidine kinase-deficient mutant of Herpes simplex virus type 1 alone and in combination with acyclovir (1997) International Journal of Antimicrobial Agents, 9, pp. 49-55
- Alché, L.E., Barquero, A.A., Sanjuan, N.A., Coto, C.E., An antiviral principle present in a purified fraction from Melia azedarach L. leaf aqueous extract restrains Herpes simplex virus type 1 propagation (2001) Phytotherapy Research, , in press
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- Thomas, J., Rouse, B.T., Immunopathogenesis of herpetic ocular disease (1997) Immunological Research, 16, pp. 375-386
- Banks, T.A., Hariharan, M.J., Rouse, B.T., Assessing cell-mediated immune responses to HSV in murine systems (1998) Herpes Simplex Virus Protocols, pp. 327-343. , Edited by M Brown, AR MacLean. New Jersey: Humana Press
- Liuzzi, M., Déziel, R., Moss, N., Beaulieu, P., Bonneau, A.-M., Bousquet, C., Chafouleas, J.G., Guindon, Y., A potent peptidomimetic inhibitor of HSV ribonucleotide reductase with antiviral activity in vivo (1994) Nature, 372, pp. 695-698
- Duan, J., Liuzzi, M., Paris, W., Lambert, M., Lawetz, C., Moss, N., Jaramillo, J., Cordingley, M., Antiviral activity of a selective ribonucleotide reductase inhibitor against acyclovir-resistant Herpes simplex virus type 1 in vivo (1998) Antimicrobial Agents & Chemotherapy, 42, pp. 1629-1635
- Asbell, P.A., Epstein, S.P., Wallace, J.A., Epstein, D., Stewart, C.C., Burger, R.M., Efficacy of cobalt chelates in the rabbit eye model for epithelial herpetic keratitis (1998) Cornea, 17, pp. 550-557
- Courrèges, M.C., Benencia, F., Coulombié, F.C., Coto, C.E., In vitro and in vivo activities of Melia azedarach L. aqueous leaf extracts on murine lymphocytes (1998) Phytomedicine, 5, pp. 47-53
Citas:
---------- APA ----------
Alché, L.E., Berra, A. & Coto, C.E. (2001) . Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral. International Antiviral News, 9(8), 132-135.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09652310_v9_n8_p132_Alche [ ]
---------- CHICAGO ----------
Alché, L.E., Berra, A., Coto, C.E. "Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral" . International Antiviral News 9, no. 8 (2001) : 132-135.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09652310_v9_n8_p132_Alche [ ]
---------- MLA ----------
Alché, L.E., Berra, A., Coto, C.E. "Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral" . International Antiviral News, vol. 9, no. 8, 2001, pp. 132-135.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09652310_v9_n8_p132_Alche [ ]
---------- VANCOUVER ----------
Alché, L.E., Berra, A., Coto, C.E. Effective treatment of mouse herpetic stromal keratitis with meliacine, a plant-derived antiviral. Int. Antiviral News. 2001;9(8):132-135.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09652310_v9_n8_p132_Alche [ ]
