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Abstract:

Dopaminergic neurons provide reward learning signals in mammals and insects [1-4]. Recent work in Drosophila has demonstrated that water-reinforcing dopaminergic neurons are different to those for nutritious sugars [5]. Here, we tested whether the sweet taste and nutrient properties of sugar reinforcement further subdivide the fly reward system. We found that dopaminergic neurons expressing the OAMB octopamine receptor [6] specifically convey the short-term reinforcing effects of sweet taste [4]. These dopaminergic neurons project to the β′2 and γ4 regions of the mushroom body lobes. In contrast, nutrient-dependent long-term memory requires different dopaminergic neurons that project to the γ5b regions, and it can be artificially reinforced by those projecting to the β lobe and adjacent α1 region. Surprisingly, whereas artificial implantation and expression of short-term memory occur in satiated flies, formation and expression of artificial long-term memory require flies to be hungry. These studies suggest that short-term and long-term sugar memories have different physiological constraints. They also demonstrate further functional heterogeneity within the rewarding dopaminergic neuron population. © 2015 The Authors.

Registro:

Documento: Artículo
Título:Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila
Autor:Huetteroth, W.; Perisse, E.; Lin, S.; Klappenbach, M.; Burke, C.; Waddell, S.
Filiación:Centre for Neural Circuits and Behaviour, University of Oxford, Tinsley Building, Mansfield Road, Oxford, OX1 3SR, United Kingdom
Zukunftskolleg, University of Konstanz, Universitätsstraße 10, Konstanz, 78457, Germany
Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, C1428EGA, Argentina
Palabras clave:Basidiomycota; Hexapoda; Mammalia; Drosophila protein; neurotransmitter receptor; OAMB protein, Drosophila; animal; appetite; cytology; dopaminergic nerve cell; Drosophila melanogaster; female; genetics; long term memory; male; mushroom body; mutation; nutritional value; physiology; reinforcement; reward; short term memory; taste; transgenic animal; Animals; Animals, Genetically Modified; Appetitive Behavior; Dopaminergic Neurons; Drosophila melanogaster; Drosophila Proteins; Female; Male; Memory, Long-Term; Memory, Short-Term; Mushroom Bodies; Mutation; Nutritive Value; Receptors, Neurotransmitter; Reinforcement (Psychology); Reward; Taste
Año:2015
Volumen:25
Número:6
Página de inicio:751
Página de fin:758
DOI: http://dx.doi.org/10.1016/j.cub.2015.01.036
Título revista:Current Biology
Título revista abreviado:Curr. Biol.
ISSN:09609822
CODEN:CUBLE
CAS:Drosophila Proteins; OAMB protein, Drosophila; Receptors, Neurotransmitter
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09609822_v25_n6_p751_Huetteroth

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Citas:

---------- APA ----------
Huetteroth, W., Perisse, E., Lin, S., Klappenbach, M., Burke, C. & Waddell, S. (2015) . Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila. Current Biology, 25(6), 751-758.
http://dx.doi.org/10.1016/j.cub.2015.01.036
---------- CHICAGO ----------
Huetteroth, W., Perisse, E., Lin, S., Klappenbach, M., Burke, C., Waddell, S. "Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila" . Current Biology 25, no. 6 (2015) : 751-758.
http://dx.doi.org/10.1016/j.cub.2015.01.036
---------- MLA ----------
Huetteroth, W., Perisse, E., Lin, S., Klappenbach, M., Burke, C., Waddell, S. "Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila" . Current Biology, vol. 25, no. 6, 2015, pp. 751-758.
http://dx.doi.org/10.1016/j.cub.2015.01.036
---------- VANCOUVER ----------
Huetteroth, W., Perisse, E., Lin, S., Klappenbach, M., Burke, C., Waddell, S. Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in drosophila. Curr. Biol. 2015;25(6):751-758.
http://dx.doi.org/10.1016/j.cub.2015.01.036