Navegar

Colección

Datos Estadísticas

Artículo

Das, G.; Klappenbach, M.; Vrontou, E.; Perisse, E.; Clark, C.M.; Burke, C.J.; Waddell, S. "Drosophila learn opposing components of a compound food stimulus" (2014) Current Biology. 24(15):1723-1730
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Dopaminergic neurons provide value signals in mammals and insects [1-3]. During Drosophila olfactory learning, distinct subsets of dopaminergic neurons appear to assign either positive or negative value to odor representations in mushroom body neurons [4-9]. However, it is not known how flies evaluate substances that have mixed valence. Here we show that flies form short-lived aversive olfactory memories when trained with odors and sugars that are contaminated with the common insect repellent DEET. This DEET-aversive learning required the MB-MP1 dopaminergic neurons that are also required for shock learning [7]. Moreover, differential conditioning with DEET versus shock suggests that formation of these distinct aversive olfactory memories relies on a common negatively reinforcing dopaminergic mechanism. Surprisingly, as time passed after training, the behavior of DEET-sugar-trained flies reversed from conditioned odor avoidance into odor approach. In addition, flies that were compromised for reward learning exhibited a more robust and longer-lived aversive-DEET memory. These data demonstrate that flies independently process the DEET and sugar components to form parallel aversive and appetitive olfactory memories, with distinct kinetics, that compete to guide learned behavior. © 2014 The Authors.

Registro:

Documento: Artículo
Título:Drosophila learn opposing components of a compound food stimulus
Autor:Das, G.; Klappenbach, M.; Vrontou, E.; Perisse, E.; Clark, C.M.; Burke, C.J.; Waddell, S.
Filiación:Centre for Neural Circuits and Behaviour, University of Oxford, Tinsley Building, Mansfield Road, Oxford OX1 3SR, United Kingdom
Laboratorio de Neurobiología de la Memoria, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States
Palabras clave:Basidiomycota; Hexapoda; Mammalia; carbohydrate; diethyltoluamide; animal; appetite; avoidance behavior; conditioned reflex; Drosophila melanogaster; female; learning; male; metabolism; odor; physiology; smelling; Animals; Appetitive Behavior; Avoidance Learning; Carbohydrates; Conditioning, Classical; DEET; Drosophila melanogaster; Female; Learning; Male; Odors; Olfactory Perception
Año:2014
Volumen:24
Número:15
Página de inicio:1723
Página de fin:1730
DOI: http://dx.doi.org/10.1016/j.cub.2014.05.078
Título revista:Current Biology
Título revista abreviado:Curr. Biol.
ISSN:09609822
CODEN:CUBLE
CAS:diethyltoluamide, 134-62-3, 26545-51-7; Carbohydrates; DEET
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09609822_v24_n15_p1723_Das

Referencias:

  • Schultz, W., Dopamine signals for reward value and risk: Basic and recent data (2010) Behav. Brain Funct., 6, p. 24
  • Bromberg-Martin, E.S., Matsumoto, M., Hikosaka, O., Dopamine in motivational control: Rewarding, aversive, and alerting (2010) Neuron, 68, pp. 815-834
  • Waddell, S., Reinforcement signalling in Drosophila; Dopamine does it all after all (2013) Curr. Opin. Neurobiol., 23, pp. 324-329
  • Schwaerzel, M., Monastirioti, M., Scholz, H., Friggi-Grelin, F., Birman, S., Heisenberg, M., Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila (2003) J. Neurosci., 23, pp. 10495-10502
  • Claridge-Chang, A., Roorda, R.D., Vrontou, E., Sjulson, L., Li, H., Hirsh, J., Miesenböck, G., Writing memories with light-addressable reinforcement circuitry (2009) Cell, 139, pp. 405-415
  • Aso, Y., Siwanowicz, I., Bräcker, L., Ito, K., Kitamoto, T., Tanimoto, H., Specific dopaminergic neurons for the formation of labile aversive memory (2010) Curr. Biol., 20, pp. 1445-1451
  • Aso, Y., Herb, A., Ogueta, M., Siwanowicz, I., Templier, T., Friedrich, A.B., Ito, K., Tanimoto, H., Three dopamine pathways induce aversive odor memories with different stability (2012) PLoS Genet., 8, p. 1002768
  • Liu, C., Plaçais, P.Y., Yamagata, N., Pfeiffer, B.D., Aso, Y., Friedrich, A.B., Siwanowicz, I., Tanimoto, H., A subset of dopamine neurons signals reward for odour memory in Drosophila (2012) Nature, 488, pp. 512-516
  • Burke, C.J., Huetteroth, W., Owald, D., Perisse, E., Krashes, M.J., Das, G., Gohl, D., Waddell, S., Layered reward signalling through octopamine and dopamine in Drosophila (2012) Nature, 492, pp. 433-437
  • Ditzen, M., Pellegrino, M., Vosshall, L.B., Insect odorant receptors are molecular targets of the insect repellent DEET (2008) Science, 319, pp. 1838-1842
  • Pellegrino, M., Steinbach, N., Stensmyr, M.C., Hansson, B.S., Vosshall, L.B., A natural polymorphism alters odour and DEET sensitivity in an insect odorant receptor (2011) Nature, 478, pp. 511-514
  • Kain, P., Boyle, S.M., Tharadra, S.K., Guda, T., Pham, C., Dahanukar, A., Ray, A., Odour receptors and neurons for DEET and new insect repellents (2013) Nature, 502, pp. 507-512
  • Lee, Y., Kim, S.H., Montell, C., Avoiding DEET through insect gustatory receptors (2010) Neuron, 67, pp. 555-561
  • Burke, C.J., Waddell, S., Remembering nutrient quality of sugar in Drosophila (2011) Curr. Biol., 21, pp. 746-750
  • Wang, Z., Singhvi, A., Kong, P., Scott, K., Taste representations in the Drosophila brain (2004) Cell, 117, pp. 981-991
  • Thorne, N., Chromey, C., Bray, S., Amrein, H., Taste perception and coding in Drosophila (2004) Curr. Biol., 14, pp. 1065-1079
  • Zhou, L., Schnitzler, A., Agapite, J., Schwartz, L.M., Steller, H., Nambu, J.R., Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells (1997) Proc. Natl. Acad. Sci. USA, 94, pp. 5131-5136
  • Marella, S., Fischler, W., Kong, P., Asgarian, S., Rueckert, E., Scott, K., Imaging taste responses in the fly brain reveals a functional map of taste category and behavior (2006) Neuron, 49, pp. 285-295
  • Hamada, F.N., Rosenzweig, M., Kang, K., Pulver, S.R., Ghezzi, A., Jegla, T.J., Garrity, P.A., An internal thermal sensor controlling temperature preference in Drosophila (2008) Nature, 454, pp. 217-220
  • Monastirioti, M., Linn Jr., C.E.J., White, K., Characterization of Drosophila tyramine beta-hydroxylase gene and isolation of mutant flies lacking octopamine (1996) J. Neurosci., 16, pp. 3900-3911
  • Kim, Y.C., Lee, H.G., Han, K.A., D1 dopamine receptor dDA1 is required in the mushroom body neurons for aversive and appetitive learning in Drosophila (2007) J. Neurosci., 27, pp. 7640-7647
  • Kitamoto, T., Conditional modification of behavior in Drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons (2001) J. Neurobiol., 47, pp. 81-92
  • Krashes, M.J., Dasgupta, S., Vreede, A., White, B., Armstrong, J.D., Waddell, S., A neural circuit mechanism integrating motivational state with memory expression in Drosophila (2009) Cell, 139, pp. 416-427
  • Jenett, A., Rubin, G.M., Ngo, T.T., Shepherd, D., Murphy, C., Dionne, H., Pfeiffer, B.D., Jeter, J., A GAL4-driver line resource for Drosophila neurobiology (2012) Cell Rep., 2, pp. 991-1001
  • Sitaraman, D., Zars, M., Laferriere, H., Chen, Y.C., Sable-Smith, A., Kitamoto, T., Rottinghaus, G.E., Zars, T., Serotonin is necessary for place memory in Drosophila (2008) Proc. Natl. Acad. Sci. USA, 105, pp. 5579-5584
  • Tian, L., Hires, S.A., Mao, T., Huber, D., Chiappe, M.E., Chalasani, S.H., Petreanu, L., Schreiter, E.R., Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators (2009) Nat. Methods, 6, pp. 875-881
  • Friggi-Grelin, F., Coulom, H., Meller, M., Gomez, D., Hirsh, J., Birman, S., Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase (2003) J. Neurobiol., 54, pp. 618-627
  • Schultz, W., Subjective neuronal coding of reward: Temporal value discounting and risk (2010) Eur. J. Neurosci., 31, pp. 2124-2135
  • Fiorillo, C.D., Two dimensions of value: Dopamine neurons represent reward but not aversiveness (2013) Science, 341, pp. 546-549
  • Fiorillo, C.D., Yun, S.R., Song, M.R., Diversity and homogeneity in responses of midbrain dopamine neurons (2013) J. Neurosci., 33, pp. 4693-4709
  • Perisse, E., Yin, Y., Lin, A.C., Lin, S., Huetteroth, W., Waddell, S., Different kenyon cell populations drive learned approach and avoidance in Drosophila (2013) Neuron, 79, pp. 945-956
  • Dethier, V.G., (1976) The Hungry Fly: A Physiological Study of the Behaviour, , Harvard University Press Cambridge
  • Marella, S., Mann, K., Scott, K., Dopaminergic modulation of sucrose acceptance behavior in Drosophila (2012) Neuron, 73, pp. 941-950
  • Scott, K., Brady Jr., R.J., Cravchik, A., Morozov, P., Rzhetsky, A., Zuker, C., Axel, R., A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila (2001) Cell, 104, pp. 661-673
  • Lin, A.C., Bygrave, A.M., De Calignon, A., Lee, T., Miesenböck, G., Sparse, decorrelated odor coding in the mushroom body enhances learned odor discrimination (2014) Nat. Neurosci., 17, pp. 559-568

Citas:

---------- APA ----------
Das, G., Klappenbach, M., Vrontou, E., Perisse, E., Clark, C.M., Burke, C.J. & Waddell, S. (2014) . Drosophila learn opposing components of a compound food stimulus. Current Biology, 24(15), 1723-1730.
http://dx.doi.org/10.1016/j.cub.2014.05.078
---------- CHICAGO ----------
Das, G., Klappenbach, M., Vrontou, E., Perisse, E., Clark, C.M., Burke, C.J., et al. "Drosophila learn opposing components of a compound food stimulus" . Current Biology 24, no. 15 (2014) : 1723-1730.
http://dx.doi.org/10.1016/j.cub.2014.05.078
---------- MLA ----------
Das, G., Klappenbach, M., Vrontou, E., Perisse, E., Clark, C.M., Burke, C.J., et al. "Drosophila learn opposing components of a compound food stimulus" . Current Biology, vol. 24, no. 15, 2014, pp. 1723-1730.
http://dx.doi.org/10.1016/j.cub.2014.05.078
---------- VANCOUVER ----------
Das, G., Klappenbach, M., Vrontou, E., Perisse, E., Clark, C.M., Burke, C.J., et al. Drosophila learn opposing components of a compound food stimulus. Curr. Biol. 2014;24(15):1723-1730.
http://dx.doi.org/10.1016/j.cub.2014.05.078