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Abstract:

Short interfering RNAs trigger histone silencing marks and stalling of RNA polymerase II at their genomic target sites through a mechanism termed transcriptional gene silencing (TGS). The Argonaute protein NRDE-3, along with NRDE-2, are needed for TGS in C. elegans. TGS also inhibits elongation and controls alternative splicing in mammalian cells. © 2010 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Gene silencing: Small RNAs control RNA polymerase II elongation
Autor:Alló, M.; Kornblihtt, A.R.
Filiación:Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Ciudad Universitaria, Pabellón 2, (C1428EHA) Buenos Aires, Argentina
Palabras clave:RNA polymerase II; small interfering RNA; animal; article; Caenorhabditis elegans; enzymology; gene silencing; genetic transcription; genetics; metabolism; physiology; Animals; Caenorhabditis elegans; Gene Silencing; RNA Polymerase II; RNA, Small Interfering; Transcription, Genetic; Caenorhabditis elegans; Mammalia
Año:2010
Volumen:20
Número:17
Página de inicio:R704
Página de fin:R707
DOI: http://dx.doi.org/10.1016/j.cub.2010.07.013
Título revista:Current Biology
Título revista abreviado:Curr. Biol.
ISSN:09609822
CODEN:CUBLE
CAS:RNA Polymerase II, 2.7.7.-; RNA, Small Interfering
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09609822_v20_n17_pR704_Allo

Referencias:

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Citas:

---------- APA ----------
Alló, M. & Kornblihtt, A.R. (2010) . Gene silencing: Small RNAs control RNA polymerase II elongation. Current Biology, 20(17), R704-R707.
http://dx.doi.org/10.1016/j.cub.2010.07.013
---------- CHICAGO ----------
Alló, M., Kornblihtt, A.R. "Gene silencing: Small RNAs control RNA polymerase II elongation" . Current Biology 20, no. 17 (2010) : R704-R707.
http://dx.doi.org/10.1016/j.cub.2010.07.013
---------- MLA ----------
Alló, M., Kornblihtt, A.R. "Gene silencing: Small RNAs control RNA polymerase II elongation" . Current Biology, vol. 20, no. 17, 2010, pp. R704-R707.
http://dx.doi.org/10.1016/j.cub.2010.07.013
---------- VANCOUVER ----------
Alló, M., Kornblihtt, A.R. Gene silencing: Small RNAs control RNA polymerase II elongation. Curr. Biol. 2010;20(17):R704-R707.
http://dx.doi.org/10.1016/j.cub.2010.07.013