Abstract:
In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested against Junín virus, etiological agent responsible of Argentine hemorrhagic fever. Some compounds inhibited Junín virus in the range of 13.2–389.1 µM. Two modified ribavirin analogues presented an effective concentration comparable to ribavirin but with a higher selectivity index. © 2019 Elsevier Ltd
Registro:
Documento: |
Artículo
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Título: | Modified ribavirin analogues as antiviral agents against Junín virus |
Autor: | Contin, M.; Sepúlveda, C.; Fascio, M.; Stortz, C.A.; Damonte, E.B.; D'Accorso, N.B. |
Filiación: | CONICET – Universidad de Buenos Aires, Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR), Intendente Güiraldes 2160, Buenos Aires, PC:1428, Argentina CONICET – Universidad de Buenos Aires, Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Intendente Güiraldes 2160, Buenos Aires, PC:1428, Argentina Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Intendente Güiraldes 2160, Buenos Aires, PC:1428, Argentina Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Intendente Güiraldes 2160, Buenos Aires, PC:1428, Argentina
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Palabras clave: | 1,2,3-Triazole ribose conjugates; Antiviral; Click chemistry; Junín virus; ribavirin; antiviral activity; Argentine hemorrhagic fever; Article; cell viability; drug conformation; drug determination; drug efficacy; drug selectivity; drug structure; EC50; Junin virus; nonhuman |
Año: | 2019
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Volumen: | 29
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Número: | 4
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Página de inicio: | 556
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Página de fin: | 559
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DOI: |
http://dx.doi.org/10.1016/j.bmcl.2018.12.063 |
Título revista: | Bioorganic and Medicinal Chemistry Letters
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Título revista abreviado: | Bioorg. Med. Chem. Lett.
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ISSN: | 0960894X
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CODEN: | BMCLE
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CAS: | ribavirin, 36791-04-5
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v29_n4_p556_Contin |
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Citas:
---------- APA ----------
Contin, M., Sepúlveda, C., Fascio, M., Stortz, C.A., Damonte, E.B. & D'Accorso, N.B.
(2019)
. Modified ribavirin analogues as antiviral agents against Junín virus. Bioorganic and Medicinal Chemistry Letters, 29(4), 556-559.
http://dx.doi.org/10.1016/j.bmcl.2018.12.063---------- CHICAGO ----------
Contin, M., Sepúlveda, C., Fascio, M., Stortz, C.A., Damonte, E.B., D'Accorso, N.B.
"Modified ribavirin analogues as antiviral agents against Junín virus"
. Bioorganic and Medicinal Chemistry Letters 29, no. 4
(2019) : 556-559.
http://dx.doi.org/10.1016/j.bmcl.2018.12.063---------- MLA ----------
Contin, M., Sepúlveda, C., Fascio, M., Stortz, C.A., Damonte, E.B., D'Accorso, N.B.
"Modified ribavirin analogues as antiviral agents against Junín virus"
. Bioorganic and Medicinal Chemistry Letters, vol. 29, no. 4, 2019, pp. 556-559.
http://dx.doi.org/10.1016/j.bmcl.2018.12.063---------- VANCOUVER ----------
Contin, M., Sepúlveda, C., Fascio, M., Stortz, C.A., Damonte, E.B., D'Accorso, N.B. Modified ribavirin analogues as antiviral agents against Junín virus. Bioorg. Med. Chem. Lett. 2019;29(4):556-559.
http://dx.doi.org/10.1016/j.bmcl.2018.12.063