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Pontiggia, R.; Pontiggia, O.; Simian, M.; Montserrat, J.M.; Engels, J.W.; Iribarren, A.M. "2-C-Methyluridine modified hammerhead ribozyme against the estrogen receptor" (2010) Bioorganic and Medicinal Chemistry Letters. 20(9):2806-2808
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Abstract:

A new synthesis of 2′-C-methyluridine phosphoramidite is presented. Special emphasis is dedicated to the improvement of the protection of the tertiary 2′-hydroxyl group. Comparison to previous protecting strategies and analysis of stability under 5′-DMTr removing conditions are discussed. The synthetic incorporation of this modified nucleoside into the catalytic core of a hammerhead ribozyme against the estrogen receptor α protein (ER-α), and transfection experiments in MCF-7 cell line are also presented. © 2010 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:2-C-Methyluridine modified hammerhead ribozyme against the estrogen receptor
Autor:Pontiggia, R.; Pontiggia, O.; Simian, M.; Montserrat, J.M.; Engels, J.W.; Iribarren, A.M.
Filiación:INGEBI (CONICET), Vuelta de Obligado 2490-, 1428 Buenos Aires, Argentina
Instituto de Oncología A. H. Roffo, UBA, Av. San Martín 5481, CABA, Argentina
Instituto de Ciencias, Universidad Nacional de Gral. Sarmiento, J. M. Gutierrez 1150, Los Polvorines (B1613GSX), Prov. de Bs. As., Argentina
Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany
Laboratorio de Biotransformaciones, Universidad Nacional de Quilmes, Roque Saenz Peña 352, Roque Saenz Peña 352, Argentina
Palabras clave:2′-C-methyluridine; Estrogen receptor alpha; Modified ribozyme; estrogen receptor alpha; hammerhead ribozyme; hormone receptor blocking agent; hydroxyl group; phosphoramidous acid derivative; article; cell strain MCF 7; chemical modification; controlled study; drug stability; drug synthesis; enzyme active site; genetic transfection; receptor down regulation; Cell Line, Tumor; Humans; Oligonucleotides; Receptors, Estrogen; RNA, Catalytic; RNA, Messenger; Uridine
Año:2010
Volumen:20
Número:9
Página de inicio:2806
Página de fin:2808
DOI: http://dx.doi.org/10.1016/j.bmcl.2010.03.060
Título revista:Bioorganic and Medicinal Chemistry Letters
Título revista abreviado:Bioorg. Med. Chem. Lett.
ISSN:0960894X
CODEN:BMCLE
CAS:2'-C-methyluridine; Oligonucleotides; RNA, Catalytic; RNA, Messenger; Receptors, Estrogen; Uridine, 58-96-8; hammerhead ribozyme; locked nucleic acid
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v20_n9_p2806_Pontiggia

Referencias:

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Citas:

---------- APA ----------
Pontiggia, R., Pontiggia, O., Simian, M., Montserrat, J.M., Engels, J.W. & Iribarren, A.M. (2010) . 2-C-Methyluridine modified hammerhead ribozyme against the estrogen receptor. Bioorganic and Medicinal Chemistry Letters, 20(9), 2806-2808.
http://dx.doi.org/10.1016/j.bmcl.2010.03.060
---------- CHICAGO ----------
Pontiggia, R., Pontiggia, O., Simian, M., Montserrat, J.M., Engels, J.W., Iribarren, A.M. "2-C-Methyluridine modified hammerhead ribozyme against the estrogen receptor" . Bioorganic and Medicinal Chemistry Letters 20, no. 9 (2010) : 2806-2808.
http://dx.doi.org/10.1016/j.bmcl.2010.03.060
---------- MLA ----------
Pontiggia, R., Pontiggia, O., Simian, M., Montserrat, J.M., Engels, J.W., Iribarren, A.M. "2-C-Methyluridine modified hammerhead ribozyme against the estrogen receptor" . Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 9, 2010, pp. 2806-2808.
http://dx.doi.org/10.1016/j.bmcl.2010.03.060
---------- VANCOUVER ----------
Pontiggia, R., Pontiggia, O., Simian, M., Montserrat, J.M., Engels, J.W., Iribarren, A.M. 2-C-Methyluridine modified hammerhead ribozyme against the estrogen receptor. Bioorg. Med. Chem. Lett. 2010;20(9):2806-2808.
http://dx.doi.org/10.1016/j.bmcl.2010.03.060