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Abstract:

The catalytic core of a 10-23 DNAzyme was modified using (2′R), (2′S)-2′-deoxy-2′-C-methyluridine and LNA-T. Catalytic activities under pseudo first order conditions were compared at different Mg 2+ concentrations, indicating that certain 2′-C-methyl modified DNAzymes have significant activities. Resistance against MCF-7 cell lysate and endonuclease RQ1 was also measured, showing that the introduction of 2′-C-methyl-2′-deoxynucleosides increased the stability. © 2010 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:10-23 DNAzyme modified with (2′R)- and (2′S)-2′-deoxy- 2′-C-methyluridine in the catalytic core
Autor:Robaldo, L.; Montserrat, J.M.; Iribarren, A.M.
Filiación:INGEBI (CONICET), Vuelta de Obligado 2490-(1428), Buenos Aires, Argentina
Instituto de Ciencias, Universidad Nacional de Gral. Sarmiento, J. M. Gutierrez 1150, Los Polvorines (B1613GSX), Prov. de Bs. As., Argentina
Laboratorio de Biotransformaciones, Universidad Nacional de Quilmes, Roque Saenz Peña 352 (1876) Bernal, Prov. de Bs. As., Argentina
Palabras clave:10-23 DNAzyme; 2′-Deoxy-2′-C-methyl nucleosides; 10 23 DNAzyme; 2' deoxy 2' c methyluridine; deoxyribozyme; endonuclease; endonuclease RQ1; magnesium ion; nucleoside analog; unclassified drug; uridine derivative; article; cancer cell culture; cancer resistance; catalysis; cell lysate; controlled study; DNA modification; drug synthesis; enzyme activity; human; human cell; Catalytic Domain; Cell Line, Tumor; DNA, Catalytic; DNA, Single-Stranded; Humans; Magnesium; Uridine
Año:2010
Volumen:20
Número:15
Página de inicio:4367
Página de fin:4370
DOI: http://dx.doi.org/10.1016/j.bmcl.2010.06.071
Título revista:Bioorganic and Medicinal Chemistry Letters
Título revista abreviado:Bioorg. Med. Chem. Lett.
ISSN:0960894X
CODEN:BMCLE
CAS:deoxyribozyme, 206668-15-7; endonuclease, 9055-11-2; magnesium ion, 22537-22-0; 2'-C-methyluridine; DNA, Catalytic; DNA, Single-Stranded; Magnesium, 7439-95-4; RNA-cleaving DNA 10-23; Uridine, 58-96-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v20_n15_p4367_Robaldo

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Citas:

---------- APA ----------
Robaldo, L., Montserrat, J.M. & Iribarren, A.M. (2010) . 10-23 DNAzyme modified with (2′R)- and (2′S)-2′-deoxy- 2′-C-methyluridine in the catalytic core. Bioorganic and Medicinal Chemistry Letters, 20(15), 4367-4370.
http://dx.doi.org/10.1016/j.bmcl.2010.06.071
---------- CHICAGO ----------
Robaldo, L., Montserrat, J.M., Iribarren, A.M. "10-23 DNAzyme modified with (2′R)- and (2′S)-2′-deoxy- 2′-C-methyluridine in the catalytic core" . Bioorganic and Medicinal Chemistry Letters 20, no. 15 (2010) : 4367-4370.
http://dx.doi.org/10.1016/j.bmcl.2010.06.071
---------- MLA ----------
Robaldo, L., Montserrat, J.M., Iribarren, A.M. "10-23 DNAzyme modified with (2′R)- and (2′S)-2′-deoxy- 2′-C-methyluridine in the catalytic core" . Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 15, 2010, pp. 4367-4370.
http://dx.doi.org/10.1016/j.bmcl.2010.06.071
---------- VANCOUVER ----------
Robaldo, L., Montserrat, J.M., Iribarren, A.M. 10-23 DNAzyme modified with (2′R)- and (2′S)-2′-deoxy- 2′-C-methyluridine in the catalytic core. Bioorg. Med. Chem. Lett. 2010;20(15):4367-4370.
http://dx.doi.org/10.1016/j.bmcl.2010.06.071