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Abstract:

Several derivatives of geraniol, geranylacetone, and farnesol bearing carbonate and thiolcarbonate functional groups as well as several derivatives of 4-phenoxyphenol were synthesized and tested for their respective biological activity as growth inhibitors for Trypanosoma cruzi, and for inhibition of tritium-labelled thymidine incorporation in T. cruzi cells. The results indicated that some JHA showed important activity against the development of the cells. © 1991.

Registro:

Documento: Artículo
Título:Synthesis and biological activivity of juvenele hormone analogues (JHA) for Trypanosoma cruzi
Autor:Rodriguez, J.B.; Gros, E.G.; Stoka, A.M.
Filiación:Departamento de Química orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pab. 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Instituto Nacional de Diagnostico e Investigacin de la Enfermedad de Chagas Dr. M Fatala Chaben (IND, Paseo Colón 568, 1063 Buenos Aires, Argentina
Palabras clave:juvenile hormone derivative; methoprene; article; cytotoxicity; dna synthesis; nonhuman; trypanosoma cruzi
Año:1991
Volumen:1
Número:12
Página de inicio:679
Página de fin:682
DOI: http://dx.doi.org/10.1016/S0960-894X(01)81047-7
Título revista:Bioorganic and Medicinal Chemistry Letters
Título revista abreviado:Bioorg. Med. Chem. Lett.
ISSN:0960894X
CODEN:BMCLE
CAS:methoprene, 40596-69-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v1_n12_p679_Rodriguez

Referencias:

  • Wiggleswoth, Assays on Rhodnius for juvenile hormone activity (1973) Journal of Insect Physiology, 19, p. 205
  • Pinchin, Oliveira Filho, Figueiredo, Muller, Gilbert, Szumlewicz, Benson, (1978) J. Econ. Entomol., 71, p. 950
  • Picollo Villar, Seccacini, Fontan, Zerba, (1987) Comp. Biochem. Physiol., 87 C, p. 367
  • Stoka, (1988) Rev. Arg. Microb., 20, p. 86
  • Rodriguez, Gros, Stoka, (1988) Z. Naturforsch., 43 b, p. 1038
  • Rodriguez, Gros, Stoka, (1989) Z. Naturforsch., 44 b, p. 983
  • Perlawagora-Szumlewicz, Petana, Figueiredo, (1975) Rev. Inst. Med. Trop., 17, p. 97
  • Stoka, Rivas, Segura, Rodriguez, Gros, (1990) Z. Naturforsch, 45 b, p. 96
  • Corey, Lansbury, (1983) J. Am. Chem. Soc., 105, p. 4093
  • Corey, Ohuchida, Hahl, (1984) J. Am. Chem. Soc., 106, p. 3875
  • Dorman, Jautelat, Roberts, (1971) J. Org. Chem., 36, p. 2757
  • Breitmaier, Voelter, (1987) Carbon-13 NMR Spectroscopy, , 3rd Ed., VCH, New York
  • Fijisawa, Sato, Gotoh, Kawashima, Kawara, Reaction of diketene with Grignard reagents in the presence of cobalt catalyst. A convenient method for the synthesis of 3-methylenealkanoic acids leading to terpenoids. (1982) Bulletin of the Chemical Society of Japan, 55, p. 3555

Citas:

---------- APA ----------
Rodriguez, J.B., Gros, E.G. & Stoka, A.M. (1991) . Synthesis and biological activivity of juvenele hormone analogues (JHA) for Trypanosoma cruzi. Bioorganic and Medicinal Chemistry Letters, 1(12), 679-682.
http://dx.doi.org/10.1016/S0960-894X(01)81047-7
---------- CHICAGO ----------
Rodriguez, J.B., Gros, E.G., Stoka, A.M. "Synthesis and biological activivity of juvenele hormone analogues (JHA) for Trypanosoma cruzi" . Bioorganic and Medicinal Chemistry Letters 1, no. 12 (1991) : 679-682.
http://dx.doi.org/10.1016/S0960-894X(01)81047-7
---------- MLA ----------
Rodriguez, J.B., Gros, E.G., Stoka, A.M. "Synthesis and biological activivity of juvenele hormone analogues (JHA) for Trypanosoma cruzi" . Bioorganic and Medicinal Chemistry Letters, vol. 1, no. 12, 1991, pp. 679-682.
http://dx.doi.org/10.1016/S0960-894X(01)81047-7
---------- VANCOUVER ----------
Rodriguez, J.B., Gros, E.G., Stoka, A.M. Synthesis and biological activivity of juvenele hormone analogues (JHA) for Trypanosoma cruzi. Bioorg. Med. Chem. Lett. 1991;1(12):679-682.
http://dx.doi.org/10.1016/S0960-894X(01)81047-7