Artículo
Veleiro, A.S.; Rosenstein, R.E.; Jaliffa, C.O.; Grilli, M.L.; Speroni, F.; Burton, G. "Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone" (2003) Bioorganic and Medicinal Chemistry Letters. 13(3):343-346
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Abstract:
3α-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 μM concentration 4 significantly increased GABA induced 36Cl- influx in hamster cerebral cortex synaptoneurosomes while at 20 mg/kg it decreased the percentage of hamsters showing seizures induced by 3-mercaptopropionic acid. © 2002 Elsevier Science Ltd. All rights reserved.
Registro:
| Documento: | Artículo |
| Título: | Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone |
| Autor: | Veleiro, A.S.; Rosenstein, R.E.; Jaliffa, C.O.; Grilli, M.L.; Speroni, F.; Burton, G. |
| Filiación: | Depto. de Quím. Orgán., Universidad de Buenos Aires, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina |
| Palabras clave: | 3 mercaptopropionic acid; 3alpha hydroxy 6,19 oxidopregn 4 en 20 one; 4 aminobutyric acid A receptor; acetic acid derivative; anticonvulsive agent; chloride ion; eltanolone; unclassified drug; animal cell; animal experiment; article; brain cortex; brain synaptosome; chloride transport; concentration response; controlled study; dose response; drug activity; drug synthesis; hamster; nonhuman; seizure; 3-Mercaptopropionic Acid; Animals; Cerebral Cortex; Convulsants; Cricetinae; Indicators and Reagents; Pregnanolone; Receptors, GABA-A; Seizures; Stereoisomerism; Structure-Activity Relationship; Synaptosomes; Cricetinae |
| Año: | 2003 |
| Volumen: | 13 |
| Número: | 3 |
| Página de inicio: | 343 |
| Página de fin: | 346 |
| DOI: | http://dx.doi.org/10.1016/S0960-894X(02)01019-3 |
| Título revista: | Bioorganic and Medicinal Chemistry Letters |
| Título revista abreviado: | Bioorg. Med. Chem. Lett. |
| ISSN: | 0960894X |
| CODEN: | BMCLE |
| CAS: | 3 mercaptopropionic acid, 107-96-0; eltanolone, 128-20-1; 3 alpha-hydroxy-6,19-oxidopregn-4-ene-20-one; 3-Mercaptopropionic Acid, 107-96-0; Convulsants; Indicators and Reagents; Pregnanolone, 128-20-1; Receptors, GABA-A |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v13_n3_p343_Veleiro |
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Citas:
---------- APA ----------
Veleiro, A.S., Rosenstein, R.E., Jaliffa, C.O., Grilli, M.L., Speroni, F. & Burton, G. (2003) . Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone. Bioorganic and Medicinal Chemistry Letters, 13(3), 343-346.http://dx.doi.org/10.1016/S0960-894X(02)01019-3
---------- CHICAGO ----------
Veleiro, A.S., Rosenstein, R.E., Jaliffa, C.O., Grilli, M.L., Speroni, F., Burton, G. "Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone" . Bioorganic and Medicinal Chemistry Letters 13, no. 3 (2003) : 343-346.http://dx.doi.org/10.1016/S0960-894X(02)01019-3
---------- MLA ----------
Veleiro, A.S., Rosenstein, R.E., Jaliffa, C.O., Grilli, M.L., Speroni, F., Burton, G. "Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone" . Bioorganic and Medicinal Chemistry Letters, vol. 13, no. 3, 2003, pp. 343-346.http://dx.doi.org/10.1016/S0960-894X(02)01019-3
---------- VANCOUVER ----------
Veleiro, A.S., Rosenstein, R.E., Jaliffa, C.O., Grilli, M.L., Speroni, F., Burton, G. Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone. Bioorg. Med. Chem. Lett. 2003;13(3):343-346.http://dx.doi.org/10.1016/S0960-894X(02)01019-3
