Artículo
Szajnman, S.H.; Bailey, B.N.; Docampo, R.; Rodriguez, J.B. "Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi" (2001) Bioorganic and Medicinal Chemistry Letters. 11(6):789-792
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Abstract:
We have investigated the effect of a series of bisphosphonates derived from fatty acids against Trypanosoma cruzi proliferation in in vitro assays. Some of these drugs proved to be potent inhibitors against the intracellular form of the parasite exhibiting IC50 values at the low micromolar level. As bisphosphonates are FDA clinically approved for treatment of bone resorption, their potential innocuousness makes them good candidates to control tropical diseases. © 2001 Elsevier Science Ltd.
Registro:
| Documento: | Artículo |
| Título: | Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi |
| Autor: | Szajnman, S.H.; Bailey, B.N.; Docampo, R.; Rodriguez, J.B. |
| Filiación: | Departamento de Química Orgánica, Fac. de Cie. Exact. y Nat., Univ. de Buenos Aires, Pabellon 2, Cd. Univ., 1428 Buenos Aires, Argentina Laboratory of Molecular Parasitology, Dept. of Pathobiology, Univ. of Illinois at Urbana-Champaign, 2001 S. Lincoln Ave., Urbana, IL 61802, United States |
| Palabras clave: | bisphosphonic acid derivative; fatty acid derivative; article; Chagas disease; concentration response; drug approval; drug effect; drug potency; drug structure; drug synthesis; food and drug administration; IC 50; nonhuman; osteolysis; parasite development; reaction analysis; structure analysis; tropical disease; Trypanosoma cruzi; Animals; Bone Resorption; Diphosphonates; Fatty Acids; Humans; Inhibitory Concentration 50; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi; United States; United States Food and Drug Administration; Trypanosoma; Trypanosoma cruzi |
| Año: | 2001 |
| Volumen: | 11 |
| Número: | 6 |
| Página de inicio: | 789 |
| Página de fin: | 792 |
| DOI: | http://dx.doi.org/10.1016/S0960-894X(01)00057-9 |
| Título revista: | Bioorganic and Medicinal Chemistry Letters |
| Título revista abreviado: | Bioorg. Med. Chem. Lett. |
| ISSN: | 0960894X |
| CODEN: | BMCLE |
| CAS: | Diphosphonates; Fatty Acids; Trypanocidal Agents |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v11_n6_p789_Szajnman |
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Citas:
---------- APA ----------
Szajnman, S.H., Bailey, B.N., Docampo, R. & Rodriguez, J.B. (2001) . Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi. Bioorganic and Medicinal Chemistry Letters, 11(6), 789-792.http://dx.doi.org/10.1016/S0960-894X(01)00057-9
---------- CHICAGO ----------
Szajnman, S.H., Bailey, B.N., Docampo, R., Rodriguez, J.B. "Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi" . Bioorganic and Medicinal Chemistry Letters 11, no. 6 (2001) : 789-792.http://dx.doi.org/10.1016/S0960-894X(01)00057-9
---------- MLA ----------
Szajnman, S.H., Bailey, B.N., Docampo, R., Rodriguez, J.B. "Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi" . Bioorganic and Medicinal Chemistry Letters, vol. 11, no. 6, 2001, pp. 789-792.http://dx.doi.org/10.1016/S0960-894X(01)00057-9
---------- VANCOUVER ----------
Szajnman, S.H., Bailey, B.N., Docampo, R., Rodriguez, J.B. Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi. Bioorg. Med. Chem. Lett. 2001;11(6):789-792.http://dx.doi.org/10.1016/S0960-894X(01)00057-9
