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Abstract:

Aluminum (Al) toxicity has been mainly investigated in uremic patients although healthy subjects and patients without renal insufficiency are not exempt from its potential deleterious effects. This experimental study aims to elucidate the action of different doses of Al citrate on in vivo erythropoiesis and find out whether the metal exerts a local toxic effect upon the bone marrow late erythroid progenitor cells. The groups in the first experimental series were: C1 (n = 5) controls and T(Al-1) (n = 5) rats receiving 1 μmol Al citrate/g body weight/day by gavage. Colony-forming units-erythroid (CFU-E) deveIopment was inhibited in the T(Al-1) group, but the median osmotic fragility (MOF) and hematocrit (Ht) values were similar to those of the C1 group. The groups in the second series were C2 (n = 5) controls and T(Al-2) (n = 5) rats receiving Al citrate in drinking water (100 mmol/l). The T(Al-2) group showed decreased Ht, hemoglobin concentration, MOF and red blood-cell life-span values (P < 0.05), and a marked inhibition of the CFU-E development (P < 0.01). Serum and bone Al concentrations were increased in both Al-treated groups (P < 0.01). There was a dose-dependent increase in bone Al levels (P < 0.01) and a dose-dependent decrease of CFU-E development (P < 0.05). The CFU-E development was inversely correlated with the bone Al content (r = -0.79; P < 0.05). The results demonstrate that even very low doses of Al citrate impair erythropoiesis in vivo and higher doses exert a deleterious action on both CFU-E and mature erythrocytes. This might show a local effect of Al on CFU-E caused by the bone sensitivity to the metal accumulation.

Registro:

Documento: Artículo
Título:Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis
Autor:Garbossa, G.; Gálvez, G.; Castro, M.E.; Nesse, A.
Filiación:Depto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Ctro. Estud. Farmacologicos y B., CONICET, Argentina
Palabras clave:Aluminium toxicity; Aluminum; CFU-E; Mean red blood-cell life-span; Median osmotic fragility; aluminum; aluminum citrate; drinking water; hemoglobin; animal cell; animal experiment; article; blood level; bone level; bone marrow; colony forming unit E; controlled study; dyserythropoiesis; erythrocyte fragility; erythroid precursor cell; hematocrit; hemoglobin determination; kidney function; male; nephrotoxicity; nonhuman; priority journal; rat
Año:1998
Volumen:17
Número:6
Página de inicio:312
Página de fin:317
DOI: http://dx.doi.org/10.1191/096032798678908819
Título revista:Human and Experimental Toxicology
Título revista abreviado:Hum. Exp. Toxicol.
ISSN:09603271
CODEN:HETOE
CAS:aluminum, 7429-90-5; aluminum citrate, 31142-56-0; hemoglobin, 9008-02-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09603271_v17_n6_p312_Garbossa

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Citas:

---------- APA ----------
Garbossa, G., Gálvez, G., Castro, M.E. & Nesse, A. (1998) . Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis. Human and Experimental Toxicology, 17(6), 312-317.
http://dx.doi.org/10.1191/096032798678908819
---------- CHICAGO ----------
Garbossa, G., Gálvez, G., Castro, M.E., Nesse, A. "Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis" . Human and Experimental Toxicology 17, no. 6 (1998) : 312-317.
http://dx.doi.org/10.1191/096032798678908819
---------- MLA ----------
Garbossa, G., Gálvez, G., Castro, M.E., Nesse, A. "Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis" . Human and Experimental Toxicology, vol. 17, no. 6, 1998, pp. 312-317.
http://dx.doi.org/10.1191/096032798678908819
---------- VANCOUVER ----------
Garbossa, G., Gálvez, G., Castro, M.E., Nesse, A. Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis. Hum. Exp. Toxicol. 1998;17(6):312-317.
http://dx.doi.org/10.1191/096032798678908819