Artículo

Elizalde, P.V.; Lanari, C.; Molinolo, A.A.; Guerra, F.K.; Balañá, M.E.; Simian, M.; Iribarren, A.M.; Charreau, E.H. "Involvement of insulin-like growth factors-I and-II and their receptors in medroxyprogesterone acetate-induced growth of mouse mammary adenocarcinomas" (1998) Journal of Steroid Biochemistry and Molecular Biology. 67(4):305-317
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Abstract:

The role of the insulin-like growth factors (IGFs) system was investigated in hormone-dependent (HD) and -independent (HI) in vivo lines of the medroxyprogesterone acetate (MPA)-induced mammary tumor model in Balb/c mice. IGF-II protein and message showed a three- to four-fold increase in HD lines growing in MPA-treated mice, as compared with HD tumors growing in untreated mice. Progression to a hormone-independent phenotype in all these lines was accompanied by a high constitutive expression of IGF-II. Similar IGF-I mRNA levels were detected in HD and HI lines. Both IGE-I and -II messages arose from the malignant epithelial cells, as shown by in situ hybridization studies. A significant decrease in Man-6P/type II IGF-R content was detected in HD tumors growing in MPA-treated mice as compared with HD lines growing in untreated mice. On the other hand, in HI tumors, notwithstanding high IGF-II synthesis, the levels of Man-6P/type II IGF-R remain high. Competitive inhibition and affinity labeling studies showed an almost exclusive binding of IGF-II to Man-6P/type II IGF-R on tumor membranes. The involvement of IGFs in the growth of epithelial primary cultures of the C4-HD line was evaluated. Exogenous IGF-I potentiated MPA stimulatory effect at concentrations of 50-100 ng/ml. Treatment of C4-HD cells with antisense oligodeoxynucleotides (ASODNs) to type I IGF-R and to IGF-II RNA resulted in a dose-dependent inhibition of MPA-mediated cell proliferation. The inhibition caused by IGF-II ASODNs could not be overcome by the addition of IGF-II up to 150 ng/ml. ASODNs to type I IGF-R at 40 μg/ml reduced by 75% the number of type I IGF-R; ASODNs to IGF-II at 1 μM decreased by 83% the levels of IGF-II protein. Our results provide support for the involvement of IGE-I and -II in MPA-induced mammary tumor growth by autocrine pathways.

Registro:

Documento: Artículo
Título:Involvement of insulin-like growth factors-I and-II and their receptors in medroxyprogesterone acetate-induced growth of mouse mammary adenocarcinomas
Autor:Elizalde, P.V.; Lanari, C.; Molinolo, A.A.; Guerra, F.K.; Balañá, M.E.; Simian, M.; Iribarren, A.M.; Charreau, E.H.
Filiación:Inst. de Biologia y Med. Exp. IBYME, Obligado 2490, Buenos Aires 1428, Argentina
Inst. de Invest. en Ingeniera G., Obligado 2490, Buenos Aires 1428, Argentina
Palabras clave:somatomedin b; somatomedin b receptor; somatomedin c; somatomedin c receptor; animal cell; animal experiment; animal model; animal tissue; article; breast adenocarcinoma; breast epithelium; cancer growth; cell proliferation; controlled study; female; in situ hybridization; mouse; nonhuman; protein expression; Adenocarcinoma; Animals; Base Sequence; Cell Division; Female; In Situ Hybridization; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Mammary Neoplasms, Experimental; Medroxyprogesterone 17-Acetate; Mice; Mice, Inbred BALB C; Oligonucleotides, Antisense; Receptor, IGF Type 1; Receptor, IGF Type 2; Tumor Cells, Cultured; Animalia
Año:1998
Volumen:67
Número:4
Página de inicio:305
Página de fin:317
DOI: http://dx.doi.org/10.1016/S0960-0760(98)00123-X
Título revista:Journal of Steroid Biochemistry and Molecular Biology
Título revista abreviado:J. Steroid Biochem. Mol. Biol.
ISSN:09600760
CODEN:JSBBE
CAS:Insulin-Like Growth Factor I, 67763-96-6; Insulin-Like Growth Factor II, 67763-97-7; Medroxyprogesterone 17-Acetate, 71-58-9; Oligonucleotides, Antisense; Receptor, IGF Type 1, EC 2.7.1.112; Receptor, IGF Type 2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v67_n4_p305_Elizalde

Referencias:

  • Molinolo, A.A., Lanari, C., Charreau, E.H., San Juan, N., Dosne Pasqualini, C., Mouse mammary tumors induced by medroxyprogesterone acetate: Immunohistochemistry and hormonal receptors (1987) J. Natl. Cancer Inst., 79, pp. 1341-1350
  • Lanari, C., Kordon, E., Molinolo, A.A., Dosne Pasqualini, C., Charreau, E.H., Mammary adenocarcinomas induced by medroxyprogesterone acetate: Hormone dependence and EGF receptors of BALB/c in vivo sublines (1989) Int. J. Cancer, 43, pp. 845-850
  • Elizalde, P.V., Lanari, C., Bussman, L., Kordon, E., Guerra, F., Savin, M., Charreau, E.H., Insulin-like growth factor production and receptors in mammary adenocarcinomas induced by medroxyprogesterone acetate in Balb/c mice (1990) J. Exp. Clin. Cancer Res., 9, pp. 193-203
  • Elizalde, P.V., Lanari, C., Kordon, E., Tezón, J., Charreau, E.H., Transforming growth factor-β activities in "in vivo" lines of hormone-dependent and independent mammary adenocarcinomas induced by medroxyprogesterone acetate in BALB/c mice (1990) Breast Cancer Res. Treat., 16, pp. 29-39
  • Elizalde, P.V., Guerra, F.K., Gravano, M., Lanari, C., Lippman, M.E., Charreau, E.H., Lupu, R., Correlation of TGF-β1 expression with medroxyprogesterone acetate responsiveness in mouse mammary adenocarcinomas (1995) Cancer Invest., 13, pp. 181-187
  • Dran, G., Luthy, I.A., Molinolo, A.A., Montecchia, F., Charreau, E.H., Dosne Pasqualini, C., Lanari, C., Effect of medroxyprogesterone acetate (MPA) and serum factors on cell proliferation in primary cultures of an MPA-induced mammary adenocarcinoma (1995) Breast Cancer Res. Treat., 35, pp. 173-186
  • Westley, B.R., May, F.E.B., Role of insulin-like growth factors in steroid modulated proliferation (1994) J. Steroid Biochem. Mol. Biol., 51, pp. 1-9
  • Brunner, N., Moser, C., Clarke, R., Cullen, K.J., IGF-I and IGF-II expression in human breast cancer xenografts: Relationship to hormone independence (1992) Breast Cancer Res. Treat., 22, pp. 39-45
  • Manni, A., Badger, B., Wei, L., Zaenglein, A., Grove, R., Khin, S., Heitjan, D., Ling, N., Hormonal regulation of insulin-like growth factor II and insulin-like growth factor binding protein expression by breast cancer cells in vivo: Evidence for stromal epithelial interactions (1994) Cancer Res., 54, pp. 2934-2942
  • Yee, D., The insulin-like growth factor system as a target in breast cancer (1994) Breast Cancer Res. Treat., 32, pp. 85-95
  • Yee, D., Cullen, K.J., Paik, S., Perdue, J.F., Lippman, M.E., Rosen, N., Insulin-like growth factor II expression in human breast cancer (1988) Cancer Res., 48, pp. 6691-6696
  • Osborne, C.K., Coronado, E.B., Kitten, L.J., Arteaga, C.L., Fuqua, S.A., Ramasharma, K., Marshall, M., Li, C.H., Insulin like growth factor II (IGF-II): A potential autocrine/ paracrine growth factor for human breast cancer acting via the IGF-I receptor (1989) Mol. Endocrinol., 3, pp. 1701-1709
  • Stewart, A.J., Johnson, M.D., May, F.E.B., Westley, B.R., Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells (1990) J. Biol. Chem., 265, pp. 21172-21178
  • Daly, R.J., Harris, W.H., Wang, D.Y., Darbre, P.D., Autocrine production of insulin-like growth factor II using an inducible expression system results in reduced estrogen sensitivity of MCF-7 human breast cancer cells (1991) Cell Growth Diff., 2, pp. 457-464
  • Cullen, K.J., Lippman, M.E., Chow, D., Hill, S., Rosen, N., Zwiebel, J., IGF-II overexpression in MCF-7 cells induced phenotypic changes associated with malignant progression. Mol (1992) Endocrinol., 6, pp. 91-100
  • Papa, V., Hartmann, K.K.P., Rosenthal, S.M., Maddux, B.A., Siiteri, P.K., Goldfine, I.D., Progestins induce down-regulation of insulin-like growth factor-I (IGF-I) receptors in human breast cancer cells: Potential autocrine rol of IGF-II (1991) Mol. Endocrinol., 5, pp. 709-717
  • Manni, A., Wright, C., Buck, H., Growth factor involvement in the multihormonal regulation of MCF-7 breast cancer cell growth in soft agar (1991) Breast Cancer Res. Treat., 20, pp. 43-52
  • Manni, A., Wright, C., Badger, B., Lynch, J., Demers, L., Role of insulin-like growth factor-related peptides in the estradiol-prolactin-and progesterone-stimulated growth of N-nitrosomethylurea-induced rat mammary tumors in soft agar (1990) Cancer Res., 50, pp. 7179-7183
  • Cho, H., Aronica, S.M., Katzenellenbogen, B.S., Regulation of progesterone receptor gene expression in MCF-7 breast cancer cells: A comparison of the effects of cyclic adenosine 3′,5′-monophosphate, estradiol, insulin-like growth factor-I and serum factors (1994) Endocrinology, 134, pp. 658-664
  • Guerra, F.K., Eijan, A.M., Puricelli, L., Alonso, D.F., Bal De Kier Joffé, E., Kornblihtt, A.R., Charreau, E.H., Elizalde, P.V., Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability (1996) Int. J. Cancer, 65, pp. 812-820
  • Barenton, B., Pate, B., Khan, M.N., Guyda, H.J., Posner, B.I., Insulin-like growth factor-binding proteins in hypophysectomized rat liver: Characterization and subcellular localization (1988) Endocrinology, 122, pp. 2499-2507
  • Scatchard, G., The attraction of proteins for small molecules and ions (1949) Ann. NY Acad. Sci., 51, pp. 660-672
  • Laemmli, U.K., Cleavaje of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 227, pp. 680-685
  • Young, J.A.T., Trowsdale, J., A processed pseudogene in an intron of the HLA-DPb1 chain gene is a member of the ribosomal protein L32 gene family (1985) Nucleic Acids Res., 13, pp. 8883-8891
  • Chirgwin, J., Pryzbyla, A., McDonald, R., Rutter, W., Isolation of biologically active ribonucleic acid from sources enriched for ribonuclease (1979) Biochemistry, 18, pp. 5294-5298
  • Daughaday, W.H., Rotwein, P., Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations (1989) Endocr. Rev., 10, pp. 68-91
  • Toropainen, E., Lipponnen, P., Syrjanen, K., Expression of insulin-like growth factor I (IGF-I) in female breast cancer as related to established prognostic factors and long-term prognosis (1995) Eur. J. Cancer, 31 A, pp. 1443-1448
  • Yee, D., Paik, S., Lebovic, G.S., Marcus, R.R., Favoni, R.E., Cullen, K.J., Lippman, M.E., Rosen, N., Analysis of IGF-I gene expression in malignancy: Evidence for a paracrine role in human breast cancer (1989) Mol. Endocrinol., 3, pp. 509-517
  • Paik, S., Expression of IGF-I and II mRNA in breast tissue (1992) Breast Cancer Res. Treat., 22, pp. 31-38
  • Mathieu, M., Vignon, F., Capony, F., Rochefort, H., Estradiol down-regulates the mannose-6-phosphate/IGF-II receptor gene and induces cathepsin D in breast cancer cells: A receptor saturation mechanism to increase the secretion of lysosomal pro-enzymes (1991) Mol. Endocrinol., 5, pp. 815-822
  • Beukers, M.W., Youngman, O., Zhang, H., Ling, N., Rosenfeld, R., (Leu 27) Insulin-like growth factor II is highly selective for the type-II IGF receptor in binding, cross-linking and thymidine incorporation experiments (1991) Endocrinology, 1128, pp. 1201-1203
  • Nielsen, F.C., Wang, E., Gammeltoft, S., Receptor binding, endocytosis and mitogenesis of insulin-like growth factors I and II in fetal rat brain neurons (1991) J. Neurochem., 56, pp. 12-21
  • Sakano, K., Enjoh, T., Numata, F., Fujiwara, H., Marumoto, Y., Higashihash, N., Sata, Y., Fujita-Yamaguchu, Y., The design, expression, and characterization of human insulin-like growth factor-II (IGF-II) mutants specific for either the IGF-II/cation-independent mannose-6-phosphate receptor or IGF-I receptor (1991) J. Biol. Chem., 266, pp. 20626-20635
  • Ellis, M.J.C., Leav, B.A., Yang, Z., Rasmussen, A., Pearce, A., Zweibel, J.A., Lippman, M.E., Cullen, K.J., Affinity for the insulin-like growth factor II (IGF-II) receptor inhibits autocrine IGF-II activity in MCF-7 breast cancer cells (1996) Mol Endocrinol., 10, pp. 286-297
  • Nishimoto, I., Hata, Y., Otaga, E., Kojima, I., Insulin-like growth factor II stimulates calcium flux in competent BALB/c 3T3 cells primed with epidermal growth factor. Characteristics of calcium influx and involvement of GTP-binding protein (1987) J. Biol. Chem., 262, pp. 1220-1226
  • Minniti, C., Kohn, E., Grubb, J., Sly, W., Oh, Y., Muller, H., Rosenfeld, R., Helman, L., The insulin-like growth factor II (IGF-II)/mannose-6-phosphate receptor mediates IGF-II induced motility in human rhabdomyosarcoma cells (1992) J. Biol. Chem., 267, pp. 9000-9004
  • Korner, C., Nurnberg, B., Uhde, M., Braulke, T., Mannose 6-phosphate/insulin-like growth factor II receptor fails to interact with G proteins (1995) J. Biol. Chem., 270, pp. 287-295
  • Mathieu, M., Rochefort, H., Barenton, B., Prebois, C., Vignon, F., Interactions of cathepsin D and IGF-II on the IGF-II/M6P receptor in human breast cancer cells and possible consequences on mitogenic activity of IGF-II (1990) Mol. Endocrinol., 4, pp. 1327-1335
  • Arteaga, C.L., Kitten, L.J., Coronado, E.B., Jacobs, S., Kul F.C., Jr., Allred, D.C., Osborne, C.K., Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice (1989) J. Clin. Invest., 84, pp. 1418-1423
  • Brunner, N., Yee, D., Kern, F.G., Spang-Thomsen, M., Lippman, M.E., Cullen, K.J., Effect of endocrine therapy on growth of T61 human breast cancer xenografts is directly correlated to specific down-regulation of insulin-like growth factor II (1993) Europ. J. Cancer, 29 A, pp. 562-569
  • Arteaga, C.L., Osborne, C.K., Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor (1989) Cancer Res., 49, pp. 6237-6241
  • Cullen, K.J., Yee, D., Sly, W.S., Perdue, J., Hampton, B., Lippman, M.E., Rosen, N., Insulin-like growth factor receptor expression and function in human breast cancer (1990) Cancer Res., 50, pp. 48-53
  • Aronica, S.M., Katzenellenbogen, B.S., Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I (1993) Mol. Endocrinol., 7, pp. 743-752
  • Pradger, D., Li, H.L., Asa, S., Melmed, S., Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor-I receptor mutant (1994) Proc. Natl. Acad. Sci. U.S.A., 91, pp. 2181-2185
  • Resnicoff, M., Coppola, D., Sell, C., Rubin, R., Ferrone, S., Baserga, R., Growth inhibition of human melanoma cells in nude mice by antisense strategies to type I insulin-like growth factor receptor (1994) Cancer Res., 54, pp. 4848-4850
  • Resnicoff, M., Sell, C., Rubini, M., Coppola, D., Ambrose, D., Baserga, R., Rubin, R., Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors (1994) Cancer Res., 54, pp. 2218-2222
  • Sell, C., Dumenil, G., Deveaud, C., Miura, M., Coppola, D., Deangelis, T., Rubin, R., Baserga, R., Effect of a null mutation of the type I IGF receptor gene on growth and transformation of mouse embryo fibroblasts (1994) Mol. Cell Biol., 14, pp. 3604-3612
  • Baserga, R., The insulin-like growth factor I receptor: A key to tumor growth (1995) Cancer Res., 55, pp. 249-252
  • Neuenschwander, S., Roberts, C.T., Leroith, D., Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid (1995) Endocrinology, 136, pp. 4298-4303
  • Moats-Staats, B.M., Retsch-Bogart, G.Z., Price, W.A., Jarvis, H.W., D'Ercole, A.J., Stiles, A.D., Insulin-like growth factor-I (IGF-I) antisense oligodeoxynucleotide mediated inhibition of DNA synthesis by WI-38 cells: Evidence for autocrine actions of IGF-I (1993) Mol. Endocrinol., 7, pp. 171-180
  • Lee, A.V., Darbre, P., King, R.J.B., Processing of insulin-like growth factor II (IGF-II) by human breast cancer cells (1994) Mol. Cell. Endocrinol., 99, pp. 211-220

Citas:

---------- APA ----------
Elizalde, P.V., Lanari, C., Molinolo, A.A., Guerra, F.K., Balañá, M.E., Simian, M., Iribarren, A.M.,..., Charreau, E.H. (1998) . Involvement of insulin-like growth factors-I and-II and their receptors in medroxyprogesterone acetate-induced growth of mouse mammary adenocarcinomas. Journal of Steroid Biochemistry and Molecular Biology, 67(4), 305-317.
http://dx.doi.org/10.1016/S0960-0760(98)00123-X
---------- CHICAGO ----------
Elizalde, P.V., Lanari, C., Molinolo, A.A., Guerra, F.K., Balañá, M.E., Simian, M., et al. "Involvement of insulin-like growth factors-I and-II and their receptors in medroxyprogesterone acetate-induced growth of mouse mammary adenocarcinomas" . Journal of Steroid Biochemistry and Molecular Biology 67, no. 4 (1998) : 305-317.
http://dx.doi.org/10.1016/S0960-0760(98)00123-X
---------- MLA ----------
Elizalde, P.V., Lanari, C., Molinolo, A.A., Guerra, F.K., Balañá, M.E., Simian, M., et al. "Involvement of insulin-like growth factors-I and-II and their receptors in medroxyprogesterone acetate-induced growth of mouse mammary adenocarcinomas" . Journal of Steroid Biochemistry and Molecular Biology, vol. 67, no. 4, 1998, pp. 305-317.
http://dx.doi.org/10.1016/S0960-0760(98)00123-X
---------- VANCOUVER ----------
Elizalde, P.V., Lanari, C., Molinolo, A.A., Guerra, F.K., Balañá, M.E., Simian, M., et al. Involvement of insulin-like growth factors-I and-II and their receptors in medroxyprogesterone acetate-induced growth of mouse mammary adenocarcinomas. J. Steroid Biochem. Mol. Biol. 1998;67(4):305-317.
http://dx.doi.org/10.1016/S0960-0760(98)00123-X