Artículo

De Nicola, A.F.; Ferrini, M.; Gonzalez, S.L.; Gonzalez Deniselle, M.C.; Grillo, C.A.; Piroli, G.; Saravia, F.; De Kloet, E.R. "Regulation of gene expression by corticoid hormones in the brain and spinal cord" (1998) Journal of Steroid Biochemistry and Molecular Biology. 65(1-6):253-272
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Abstract:

Glucocorticoids (GC) and mineralocorticoids (MC) have profound regulatory effects upon the central nervous system (CNS). Hormonal regulation affects several molecules essential to CNS function. First, evidences are presented that mRNA expression of the α3 and β1-subunits of the Na,K- ATPase are increased by GC and physiological doses of MC in a region- dependent manner. Instead, high MC doses reduce the β1 isoform and enzyme activity in amygdaloid and hypothalamic nuclei, an effect which may be related to MC control of salt appetite. The α3-subunit mRNA of the Na,K- ATPase is also stimulated by GC in motoneurons of the injured spinal cord, suggesting a role for the enzyme in GC neuroprotection. Second, we provide evidences for hormonal effects on the expression of mRNA for the neuropeptide arginine vasopressin (AVP). Our data show that GC inhibition of AVP mRNA levels in the paraventricular nucleus is sex-hormone dependent. This sexual dimorphism may explain sex differences in the hypothalamic-pituitary-adrenal axis function between female and male rats. Third, steroid effects on the astrocyte marker glial fibrillary acidic protein (GFAP) points to a complex regulatory mechanism. In an animal model of neurodegeneration (the Wobbler mouse) showing pronounced astrogliosis of the spinal cord, in vivo GC treatment down-regulated GFAP immunoreactivity, whereas the membrane-active steroid antioxidant U74389F up-regulated this protein. It is likely that variations in GFAP protein expression affect spinal cord neurodegeneration in Wobbler mice. Fourth, an interaction between neurotrophins and GC is shown in the injured rat spinal cord. In this model, intensive GC treatment increases immunoreactive low affinity nerve growth factor (NGF) receptor in motoneuron processes. Because GC also increases immunoreactive NGF, this mechanism would support trophism and regeneration in damaged tissues. In conclusion, evidences show that some molecules regulated by adrenal steroids in neurons and glial cells are not only involved in physiological control, but additionally, may play important roles in neuropathology.

Registro:

Documento: Artículo
Título:Regulation of gene expression by corticoid hormones in the brain and spinal cord
Autor:De Nicola, A.F.; Ferrini, M.; Gonzalez, S.L.; Gonzalez Deniselle, M.C.; Grillo, C.A.; Piroli, G.; Saravia, F.; De Kloet, E.R.
Filiación:Lab. of Neuroendocrine Biochemistry, Inst. of Biol. and Exp. Med.-CONICET, Obligado 2490, 1428 Buenos Aires, Argentina
Department of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
Division of Medical Pharmacology, Leiden/Amsterdam Ctr. for Drug Res., Leiden University, Leiden, Netherlands
Palabras clave:adenosine triphosphatase (potassium sodium); aldosterone; argipressin; corticosteroid; dexamethasone; glial fibrillary acidic protein; messenger rna; nerve growth factor receptor; neurotrophin; animal cell; animal tissue; central nervous system; conference paper; gene expression regulation; hormonal regulation; immunoreactivity; neuropathology; nonhuman; rat; regulatory mechanism; sex difference; spinal cord transsection; Adrenal Cortex Hormones; Animals; Arginine Vasopressin; Brain; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Male; Na(+)-K(+)-Exchanging ATPase; Rats; Sex Characteristics; Spinal Cord; Animalia; Eukaryota
Año:1998
Volumen:65
Número:1-6
Página de inicio:253
Página de fin:272
DOI: http://dx.doi.org/10.1016/S0960-0760(97)00190-8
Título revista:Journal of Steroid Biochemistry and Molecular Biology
Título revista abreviado:J. Steroid Biochem. Mol. Biol.
ISSN:09600760
CODEN:JSBBE
CAS:Adrenal Cortex Hormones; Arginine Vasopressin, 113-79-1; Glial Fibrillary Acidic Protein; Na(+)-K(+)-Exchanging ATPase, EC 3.6.1.37
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v65_n1-6_p253_DeNicola

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Citas:

---------- APA ----------
De Nicola, A.F., Ferrini, M., Gonzalez, S.L., Gonzalez Deniselle, M.C., Grillo, C.A., Piroli, G., Saravia, F.,..., De Kloet, E.R. (1998) . Regulation of gene expression by corticoid hormones in the brain and spinal cord. Journal of Steroid Biochemistry and Molecular Biology, 65(1-6), 253-272.
http://dx.doi.org/10.1016/S0960-0760(97)00190-8
---------- CHICAGO ----------
De Nicola, A.F., Ferrini, M., Gonzalez, S.L., Gonzalez Deniselle, M.C., Grillo, C.A., Piroli, G., et al. "Regulation of gene expression by corticoid hormones in the brain and spinal cord" . Journal of Steroid Biochemistry and Molecular Biology 65, no. 1-6 (1998) : 253-272.
http://dx.doi.org/10.1016/S0960-0760(97)00190-8
---------- MLA ----------
De Nicola, A.F., Ferrini, M., Gonzalez, S.L., Gonzalez Deniselle, M.C., Grillo, C.A., Piroli, G., et al. "Regulation of gene expression by corticoid hormones in the brain and spinal cord" . Journal of Steroid Biochemistry and Molecular Biology, vol. 65, no. 1-6, 1998, pp. 253-272.
http://dx.doi.org/10.1016/S0960-0760(97)00190-8
---------- VANCOUVER ----------
De Nicola, A.F., Ferrini, M., Gonzalez, S.L., Gonzalez Deniselle, M.C., Grillo, C.A., Piroli, G., et al. Regulation of gene expression by corticoid hormones in the brain and spinal cord. J. Steroid Biochem. Mol. Biol. 1998;65(1-6):253-272.
http://dx.doi.org/10.1016/S0960-0760(97)00190-8